Papillary Cystadenocarcinoma of Salivary-Glands - An Immunohistochemical Study

Shrestha, Pragya; Namba, Miyako; Yang, Lijun; Liu, Bl; Oosumi, Hiroyuki; Mori, Masahiko

doi:10.3892/ijo.4.3.587

Cited by 6 publications

(6 citation statements)

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“…The immunoprofile of our tumor supports the ductal and luminal differentiation and is consistent with other reports. 19,20 In summary, CAC is a rare low-grade carcinoma of the salivary gland. The diagnosis can be suggested on FNA smears, however, confirmation and distinction from its benign counterpart cystadenoma needs histologic confirmation of stromal invasion.…”

Section: Discussionmentioning

confidence: 99%

Low‐grade papillary cystadenocarcinoma of the parotid gland: Presentation of a case with cytological, histopathological, and immunohistochemical features and pertinent literature review

Aloudah

Raddaoui

Aldhahri

et al. 2008

Diagnostic Cytopathology

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Cystadenocarcinoma of the salivary glands is a very rare, slow growing, low-grade malignant neoplasm. However, when it occurs, it poses a diagnostic challenge. They are usually well circumscribed and exhibit multicystic appearance. The cytological features of fine-needle aspirates show bland appearing papillary and micropapillary neoplasm with variable cellularity and absence of cytological atypia. The cells are small to medium in size with abundant and occasionally vacuolated cytoplasm. The nuclei are eccentric, bland appearing, round, and at the most part uniform in size without anaplasia or mitotic activity. The background is commonly mucoid. Histologically, the neoplasm is usually well circumscribed and contains variably sized multicystic spaces with papillary structures. Foci of definite stromal invasion by tumor cells have to be present to justify the diagnosis of carcinoma. The remainders of the cytological features are similar to these seen on cytological smears. Typically, they are slow growing and conservative, but complete surgical excision is considered adequate. We present a case in a 57-year-old Saudi man that we believe the first from our region demonstrating the clinical and pathological features.

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Section: Discussionmentioning

confidence: 99%

Low‐grade papillary cystadenocarcinoma of the parotid gland: Presentation of a case with cytological, histopathological, and immunohistochemical features and pertinent literature review

Aloudah

Raddaoui

Aldhahri

et al. 2008

Diagnostic Cytopathology

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“…A positive immunoreactivity of vimentin, S-100 protein and focal expression of actin and GFAP has suggested the myoepithelial differentiation of clear tumor cells. Although papillary cystadenocarcinoma has been described as more common in minor salivary glands [148], we have recently found this tumor in major glands and immunohistochemical characteristics have shown positive immunoreactivity for cytokeratins, vimentin, NSE, S-100 protein, polymorphous epithelial mucins MAM-6, MAM-3, lysozyme, lactoferrin and alpha-1 antichymotrypsin and GFAP suggesting the tumor mainly arise from disorganized stratification and malignant transformation of ductal cells, with tumor cell population which may be the counterparts of modified myoepithelial cells [159].…”

Section: Clear Cell Adenomas Of Adenocarcinomasmentioning

confidence: 99%

Primary Epithelial Tumors of Salivary Glands.Histomorphological and Immunohistochemical Implications.

Shrestha

Huang

Takai

et al. 1996

Acta Histochem. Cytochem

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“…2 Papillary cystadenocarcinoma is characterized by cysts and papillary endocystic projections but lacks the features of cystic variants of several common salivary gland carcinomas like polymorphous low-grade adenocarcinoma (PLGA), salivary duct carcinoma, mucoepidermoid carcinoma, and the papillary cystic variant of acinic cell carcinoma. 5,6 H e r e i n , w e d e s c r i b e a c a s e o f p a p i l l a r y cystadenocarcinoma of the parotid gland.…”

Section: Introductionmentioning

confidence: 99%

Papillary cystadenocarcinoma of the parotid gland: a rare sub-variant of salivary gland adenocarcinoma

Dutta¹,

Dey²,

Mishra³

et al. 2022

Autops Case Rep

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Papillary cystadenocarcinoma of the salivary gland is a very rare malignant neoplasm accounting for only 2% of all salivary gland lesions. In 1991 it was first included as a separate entity in the World Health Organization (WHO) classification of salivary gland tumors and in 2017 WHO Classification, the tumor was clubbed as a sub-variant of adenocarcinoma, not otherwise specified. It most commonly occurs in the major salivary glands. Herein we report a case of salivary papillary cystadenocarcinoma in a 54-year-old female, who presented with rapid enlargement of the right parotid swelling. Based on radiology and fine-needle aspiration cytology, a working diagnosis of the malignant tumor involving the superficial lobe of the right parotid gland was made. In view of the malignant nature of the swelling, superficial parotidectomy was done. The histopathology and immunohistochemistry of the mass confirmed the diagnosis of papillary cystadenocarcinoma of the right parotid. With the revised 2017 WHO classification of salivary gland tumors, it is important to report all rare subtypes in order to understand their biology and behavior.

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Papillary Cystadenocarcinoma of Salivary-Glands - An Immunohistochemical Study

Cited by 6 publications

References 0 publications

Low‐grade papillary cystadenocarcinoma of the parotid gland: Presentation of a case with cytological, histopathological, and immunohistochemical features and pertinent literature review

Low‐grade papillary cystadenocarcinoma of the parotid gland: Presentation of a case with cytological, histopathological, and immunohistochemical features and pertinent literature review

Primary Epithelial Tumors of Salivary Glands.Histomorphological and Immunohistochemical Implications.

Papillary cystadenocarcinoma of the parotid gland: a rare sub-variant of salivary gland adenocarcinoma

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