Papillary carcinoma with subacute thyroiditis

Lam, Alfred King‐Yin; Lo, Chung‐Yau

doi:10.1007/s12022-002-0003-x

Cited by 7 publications

(6 citation statements)

References 3 publications

(3 reference statements)

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“…found no thyroid cancer in 160 SAT patients (8). But there are several case reports about this co-existence worldwide in the literature (9)(10)(11).…”

Section: Discussionmentioning

confidence: 99%

Papillary thyroid cancer case masked by subacute thyroiditis

Uçan

Delibaşı

Çakal

et al. 2014

Arq Bras Endocrinol Metab

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Subacute thyroiditis (SAT) association with thyroid carcinoma has been rarely reported in the literature. We present a patient with SAT and papillary thyroid cancer that was suspected by ultrasonographic evaluation (US) following SAT treatment. A fifty-four-year old female patient referred to our department due to tachycardia, jitteriness and pain in cervical region for the past one month. SAT diagnosis was established by physical examination, laboratory and ultrasonographic findings. After treatment, control thyroid US revealed regression of the hypoechogenic regions seen in both lobes, and a previously unreported hypoechogenic lesion with microcalcification focus that had irregular borders and was not clearly separated from the surrounding parenchyma located in the posterior aspect of the lobe (Elasto score: 4, Strain index: 7.08). Fine needle aspiration biopsy was taken from this nodule; cytology was assessed to be compatible with papillary thyroid carcinoma. Postsurgical pathology evaluation showed a papillary microcarcinoma. SAT may produce ultrasound changes that obscure the coexistence of papillary carcinoma. We recommend that patients with SAT have ultrasonography after they recover. Hypoechogenic regions bigger than 1 cm that are present in the follow-up post-therapy US should be assessed by biopsy.

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“…found no thyroid cancer in 160 SAT patients (8). But there are several case reports about this co-existence worldwide in the literature (9)(10)(11).…”

Section: Discussionmentioning

confidence: 99%

Papillary thyroid cancer case masked by subacute thyroiditis

Uçan

Delibaşı

Çakal

et al. 2014

Arq Bras Endocrinol Metab

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“…In most studies, thyroid cancer is associated with granulomatous form of thyroiditis (12)(13)(14)(15). The diagnosis of thyroid cancer can be challenging because subacute thyroiditis can result in ultrasound changes that obscure the coexistence of papillary carcinoma.…”

Section: Discussionmentioning

confidence: 99%

Painless thyroiditis associated to thyroid carcinoma: role of initial ultrasonography evaluation

Valentini

Macedo

Izquierdo

et al. 2016

Arch. Endocrinol. Metab.

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Even though it is a rare event, most associations of thyroid carcinoma with subacute thyroiditis described in the literature are related to its granulomatous form (Quervain's thyroiditis). We present a patient with subacute lymphocytic thyroiditis (painless thyroiditis) and papillary thyroid cancer that was first suspected in an initial ultrasound evaluation. A 30-year old female patient who was referred to the emergency room due to hyperthyroidism symptoms was diagnosed with painless thyroiditis established by physical examination and laboratory findings. With the presence of a palpable painless thyroid nodule an ultrasound was prescribed and the images revealed a suspicious thyroid nodule, microcalcification focus in the heterogeneous thyroid parenquima and cervical lymphadenopathy. Fine needle aspiration biopsy was taken from this nodule; cytology was assessed for compatibility with papillary thyroid carcinoma. Postsurgical pathology evaluation showed a multicentric papillary carcinoma and lymphocytic infiltration. Subacute thyroiditis, regardless of type, may produce transitory ultrasound changes that obscure the coexistence of papillary carcinoma. Due to this, initial thyroid ultrasound evaluation should be delayed until clinical recovery. We recommended a thyroid ultrasound exam for initial evaluation of painless thyroiditis, particularly in patients with palpable thyroid nodule. Further cytological examination is recommended in cases presenting with suspect thyroid nodule and/or non-nodular hypoechoic (> 1 cm) or heterogeneous areas with microcalcification focus. Arch Endocrinol Metab. 2016;60(2):178-82

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“…There are very few studies reporting the prevalence of thyroid cancer in patients with SAT. 1 , 7 , 8 , 9 , 10 In addition to the findings compatible with thyroiditis, ultrasonographic examination of the patients with SAT may also reveal thyroid nodules incidentally. In some patients, pseudo-nodules seen in association with thyroiditis, which cannot be distinguished easily from malignant nodules with irregular margins; and a close follow-up in parallel with the resolution of inflammatory findings of SAT may be helpful in differential diagnosis.…”

Section: Introductionmentioning

confidence: 99%

Prevalence of papillary thyroid cancer in subacute thyroiditis patients may be higher than it is presumed: retrospective analysis of 137 patients

Gül

Üzüm

Selçukbiricik

et al. 2018

Radiology and Oncology

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BackgroundThe association of subacute thyroiditis (SAT) and papillary thyroid carcinoma is a rare finding. In this study, we aimed to investigate the prevalence of differentiated thyroid cancer in a cohort of patients followed with the diagnosis of SAT.Patients and methodsWe retrospectively screened medical records of Endocrinology and Metabolism outpatient clinic in the past 20 years for patients with SAT. Patients with nodules and suspicious ultrasonography findings who underwent fine needle aspiration biopsy (FNAB) and operated due to malignancy risk were identified.ResultsWe identified 137 (100 females, 37 males) patients with reliable records to confirm the diagnosis of SAT. The mean age of female patients was 41.1 ± 9.1 (range, 20–64) and of male patients was 43.0 ± 9.3 (range, 20–65). One or more FNAB was performed in 23 of the patients (16.8%) at the beginning and/or during the follow-up period when needed. Seven patients with suspicious FNAB findings were operated, and histopathological examination of the nodules confirmed the diagnosis of papillary thyroid carcinoma in 6 patients (4.4%).ConclusionsOur observations suggesting a relatively higher prevalence of thyroid cancer in a small series of SAT patients warrant further studies to identify the real frequency of differentiated thyroid cancer and its association with inflammatory pathogenesis of SAT. This finding is compatible with the trend of increased thyroid cancer incidence all over the world. A repeat ultrasonography after resolution of clinical and inflammatory findings, and FNAB should be recommended to all patients with suspicious nodules.

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Papillary carcinoma with subacute thyroiditis

Cited by 7 publications

References 3 publications

Papillary thyroid cancer case masked by subacute thyroiditis

Papillary thyroid cancer case masked by subacute thyroiditis

Painless thyroiditis associated to thyroid carcinoma: role of initial ultrasonography evaluation

Prevalence of papillary thyroid cancer in subacute thyroiditis patients may be higher than it is presumed: retrospective analysis of 137 patients

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