Papillary carcinoma thyroid with metastasis to ectopic cervical thymus

Abstract

Papillary carcinoma of thyroid is the most common type of thyroid neoplasm which is usually confined to the thyroid and tends to metastasize to regional lymph nodes. Distant metastasis occur in up to 15% of cases. Thymic metastasis from any malignant carcinoma is extremely rare with only four cases reported in medical literature. We report a case of papillary carcinoma of thyroid metastasizing to ectopic cervical thymus which has not been previously reported.

Unusual metastases from tall cell variant of papillary thyroid cancer

“…Among the adults, in 2 patients, thymic metastases were discovered through imaging techniques during follow‐up; in the third case, the thymic metastasis was an incidental histological finding, such as in our patient. However, differently from Mushtaque et al, we described a not ectopic thymic metastasis from TCV of PTC, positive for V600E BRAF mutation. In none of the cases previously described was thymic metastases proven to be negative prognostic factors.…”

“…In fact, normal thymic cells can accumulate radioiodine . To our knowledge, only 5 true cases (3 adults and 2 children) were described . Among the adults, in 2 patients, thymic metastases were discovered through imaging techniques during follow‐up; in the third case, the thymic metastasis was an incidental histological finding, such as in our patient.…”

“…To our knowledge, only 5 true cases (3 adults and 2 children) were described . Among the adults, in 2 patients, thymic metastases were discovered through imaging techniques during follow‐up; in the third case, the thymic metastasis was an incidental histological finding, such as in our patient. However, differently from Mushtaque et al, we described a not ectopic thymic metastasis from TCV of PTC, positive for V600E BRAF mutation.…”

Colorectal Cancer Metastasis to the Thymus Gland: Rare Presentation of Colorectal Cancer as Anterior Mediastinal Mass

“…The thymus gland's role in cellular immunity and the presence of a blood-thymus barrier typically prevents the parenchyma of the thymus from direct contact with tumor cells or antigens [6]. However, the blood vessels, lymphatics, and nerves making up the capsule and interlobular septum of the thymus gland provide the most plausible route for seeding of tumor cells from primary tumors [7]. Ours is the first case report to show metastatic colorectal cancer to the thymus with immunophenotypic and genetic comparisons of the primary tumor and the thymic metastasis.…”

Papillary Thyroid Carcinoma with Lung Metastasis Arising from Dyshormonogenetic Goiter: A Case Report

“…The patient with PTC commonly presents with asymptomatic thyroid nodules. Symptoms including pain, respiratory insufficiency, stridor, vocal cord paralysis, and hemoptysis may also be seen [ 17 ]. The current patient presented with cough, sputum, fatigue, and pain in the chest.…”