Papillary Carcinoma of Thyroid with an Unusual Presentation

Baser, Brajendra; Munjal, Vishal R.; Roy, Manya Thakur

doi:10.1007/s12070-014-0746-y

Cited by 7 publications

(2 citation statements)

References 19 publications

(16 reference statements)

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“…There have been several case reports published on Cystic Papillary Thyroid Carcinoma including those by Patil 13 Baser 14 and Pratinidhi. 15 In those case reports, the patients were all females presenting with large multiple neck masses that were noted on examination.…”

Section: Discussionmentioning

confidence: 99%

Cystic Papillary Thyroid Carcinoma: A Case Report

Totesora¹,

Chua-Agcaoili²

2019

JAFES

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Cystic nodule is an unusual presentation of Papillary Thyroid Carcinoma (PTC), seen in less than 10% of cases. Even by ultrasound, finding a thyroid cyst carries a less than 5% chance of malignancy. We present a case of a 45-year-old male, who came in for incidental finding of a palpable thyroid mass with no significant predisposing history. Thyroidectomy was done and immunohistochemical staining confirmed it to be papillary thyroid cancer. He underwent high dose radiation therapy with post therapy whole body scan showing no evidence of radioavid foci aside from the thyroid bed.The malignant potential of cystic nodule(s) should never be overlooked in certain select patients even if it carries a low chance of malignancy. The diagnosis of PTC relies primarily on the typical nuclear features, however in cases of histologic uncertainty, immunohistochemical stains such as HBME-1 may be used to help classify unusual presentations of PTC. Treatment and monitoring of Cystic Papillary Thyroid Carcinoma follows the conventional guideline on solid PTC.

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Section: Discussionmentioning

confidence: 99%

Cystic Papillary Thyroid Carcinoma: A Case Report

Totesora¹,

Chua-Agcaoili²

2019

JAFES

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“…D uring past several decades, increasing incidences of papillary thyroid carcinoma (PTC) have been observed in several countries around the globe (Baser et al, 2015). In China, the incidence rate of thyroid cancer is rising by approximately 14.5% per year (Alath et al, 2015).…”

Section: Introductionmentioning

confidence: 99%

MicroRNA-16 Down-regulates BCL2 Expression and Induces Papillary Thyroid Carcinoma Cell Apoptosis Via Extracellular-regulated Kinase Pathway

Yang¹

2020

PJZ

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Papillary thyroid cancer is one of the most common tumours subtype in thyroid cancers. Substantial amount of data have indicated that miR-16 is an important regulator of various tumours; however, the molecular functions of miR-16 in papillary thyroid cancer remained largely elusive. In order to investigate the regulation of miR-16, human papillary thyroid carcinoma cells are transfected with miR-16 mimics or inhibitors. Targeting miR-16 and using dual-luciferase reporter assay, qRT-PCR and Western blot, the mRNA and protein expression were detected, respectively. Cellular apoptosis were examined by flow cytometry and Western blots was applied to assess the cleaved caspase-3, -8, -9, and cleaved poly-ADP-ribose polymerase. Protein expression of extracellular-regulated kinase were detected. Finally, data analysed statistically to determine significantly differences among groups. Results showed that breakpoint cluster 2 was a direct target of miR-16, and the expression was negatively correlated. Moreover, miR-16 promoted apoptosis suppressing breakpoint cluster 2 through phosphorylation of extracellular-regulated kinase. The study validates miR-16 as a tumour suppressor gene in papillary thyroid cancer cells, and revealed a novel mechanism of miR-16-mediated apoptosis through extracellular-regulated kinase pathway.

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