Papillary carcinoma of the prostate, location, morphology, and immunohistochemistry: The histogenesis and entity of so‐called endometrioid carcinoma

Wernert, Nicolas; Lüchtrath, H; Seeliger, H; Schäfer, Markus; Goebbels, R.; Dhom, G.

doi:10.1002/pros.2990100204

Cited by 30 publications

(8 citation statements)

References 19 publications

(1 reference statement)

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“…Other authors had published reports of prostatic ductal carcinoma, morphologically identical to endometrioid carcinoma, but originating in the primary or secondary ducts of the prostate and hence distant from any vestigial uterine tissue. Wenert et al 14 made a detailed study of this topic and tried to disprove the prostatic utricle origin of the lesion, the peri-urethral transition zone, adjacent to the main ejaculatory ducts having been suggested as a possible site of origin. Clearly a variety of locations within the ductal system of the prostate are possible.…”

Section: Discussionmentioning

confidence: 99%

Ductal (endometrioid) adenocarcinoma of the prostate: a clinicopathological study of 16 cases

1996

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Sixteen cases of ductal (endometrioid) carcinoma of the prostate are presented. The tumour presents in elderly men (age range 65-87 years) with haematuria or obstructive symptoms. Serum prostate specific antigen may be normal or raised. On cytoscopy, there is often an exophytic lesion in the region of the verumontanum. Histologically, two variants are recognized: papillary and cribriform, of which there were eight cases each. Eight cases consisted of pure ductal carcinoma and seven were mixed, containing a variable proportion of micro-acinar carcinoma. The associated micro-acinar carcinoma had a Gleason score of at least 5. One case of carcinosarcoma with a ductal epithelial component was also included. All cases displayed positive immunohistochemical staining for prostate specific antigen and prostatic acid phosphatase and but were negative for the basal cell marker MA903. The tumour responds well to orthodox micro-acinar carcinoma therapy and appears notably sensitive to hormonal manipulation. Follow-up of the mixed group is restricted to a maximum of 3 years. Of the eight pure cases, five patients are still alive with survival periods of 11, 8, 7, 3 and 1 years. Three patients died of intercurrent disease of which one patient survived 12 years, having received no treatment. This tumour, therefore, can be regarded as having a good prognosis.

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Section: Discussionmentioning

confidence: 99%

Ductal (endometrioid) adenocarcinoma of the prostate: a clinicopathological study of 16 cases

1996

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“…Due to its appearance, ductal adenocarcinoma was previously thought to arise from Mullerian remnants and possess unique clinical features related to its origin. 7 While further analyses have shown that these tumors do arise from prostatic tissue, 8, 9 speculation regarding the unique clinical features of this tumor remains.…”

Section: Introductionmentioning

confidence: 99%

Ductal Adenocarcinoma of the Prostate: Increased Mortality Risk and Decreased Serum Prostate Specific Antigen

et al. 2010

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Introduction and Objectives The clinical significance of ductal prostatic carcinoma has not been well defined. We utilized a population-based cancer registry to identify a large group of ductal carcinoma cases to characterize the impact of the ductal subtype on the presentation and survival of men with prostate cancer. Methods A national cancer registry was used to identify incident cases of ductal and acinar adenocarcinomas from 1996–2006. Clinicopathologic variables were analyzed and Cox multivariate survival analysis performed. PSA values were available for the years 2004–2006, and these were used to assess for differences in Gleason grade and serum PSA levels between ductal and acinar cancers at the time of diagnosis. Results A total of 442,881 acinar cases and 371 ductal cases were identified. Ductal cases were more likely to present with distant disease (12% vs. 4%, p<0.001) and to be poorly differentiated (50% vs. 32%; p<0.001). Ductal histology was associated with a 30% lowering of the geometric mean PSA (adjusted coeff.=0.7, 95% CI 0.6–0.8) and a more than two-fold increased odds of having a PSA<4.0 ng/ml (OR 2.4, 95% CI 1.4–4.0) independent of other clinicopathologic variables. For those with non-distant disease at diagnosis, ductal histology was associated with a 2.4-fold (CI 1.5–3.8) increased disease-specific mortality. Conclusions In the largest series of this histologic subtype, ductal cancers were more likely to present with advanced stage cancer and a lower PSA, suggesting that timely detection of the disease is a significant challenge. In addition, those with loco regional disease were more likely to die of their disease.

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“…13,14 This designation was later discarded on the basis of microscopic, ultrastructural and immunohistochemical findings and these tumours are now regarded as adenocarcinomas arising from primary prostatic ducts. 10 …”

Section: Evolution Of Nomenclaturementioning

confidence: 99%

Ductal adenocarcinoma of the prostate: histogenesis, biology and clinicopathological features

et al. 2016

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Papillary carcinoma of the prostate, location, morphology, and immunohistochemistry: The histogenesis and entity of so‐called endometrioid carcinoma

Cited by 30 publications

References 19 publications

Ductal (endometrioid) adenocarcinoma of the prostate: a clinicopathological study of 16 cases

Ductal (endometrioid) adenocarcinoma of the prostate: a clinicopathological study of 16 cases

Ductal Adenocarcinoma of the Prostate: Increased Mortality Risk and Decreased Serum Prostate Specific Antigen

Ductal adenocarcinoma of the prostate: histogenesis, biology and clinicopathological features

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