Papillary carcinoma arising from a thyroglossal duct cyst: A case report and literature review

Alqahtani, Saad M; Rayzah, Musaed; Mutairi, Ahmed Al; Alturiqy, Mohammed Abdulrahman Mohammed; Hendam, Ahmed T; Makhashen, Maraei Bin

doi:10.1016/j.ijscr.2022.107106

Cited by 8 publications

(7 citation statements)

References 10 publications

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“…The reported incidence of thyroid cancer in thyroglossal duct cysts is 1% ( 9 ). To date, approximately 300 cases of thyroglossal duct cyst carcinoma have been described in the English literature, mainly single case reports and small case series ( 10 ). Common histopathological types are papillary carcinoma (80%), follicular carcinoma (8%), and squamous cell carcinoma (6%), with Hurthle cell adenoma and anaplastic carcinoma as the remaining 6% ( 11 ).…”

Section: Discussionmentioning

confidence: 99%

Individual treatment strategy of thyroglossal duct cyst carcinoma: a case report

Li¹,

Zhang²,

Li³

et al. 2023

Gland Surg

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Background: Neoplasia of ectopic thyroid components is relatively rare in thyroglossal duct cysts. We report a case of histopathologically confirmed papillary thyroid carcinoma in a thyroglossal duct cyst, discuss its clinical characteristics of, and provide reference for diagnosis and treatment.Case Description: We presented a 25-year-old female went to hospital because of "a tumor in her neck".She was preoperatively diagnosed with thyroglossal duct cyst by cervical ultrasound, and enhanced computed tomography (CT). However, the solid component of the mass suggested intracystic neoplasia. She underwent Sistrunk surgical resection, and postoperative histopathology showed thyroglossal duct cyst, and papillary thyroid carcinoma in the cyst wall. The patient had no high-risk factors and had a low risk of recurrence.After full disclosure, the patient chose close follow-up, and to date there has been no recurrence.Conclusions: There are controversies regarding the origin of thyroglossal duct cyst carcinoma and the extent of surgery required, and a lack of unified treatment guidelines. We recommend tailoring individualized treatment based on individual risk stratification. By reporting this case, we hope to inform surgeons of the various abnormalities that may occur in ectopic thyroid tissue.

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Section: Discussionmentioning

confidence: 99%

Individual treatment strategy of thyroglossal duct cyst carcinoma: a case report

Li¹,

Zhang²,

Li³

et al. 2023

Gland Surg

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“…The thyroid gland begins its formation in the early embryonic period, around the third week of gestation; this occurs from endodermal tissue located between the first and second pharyngeal clefts. 9 Subsequently, it begins its descent from the cecum foramen (base of the tongue), creating a thyroid diverticulum posterior and caudal to the hyoid bone, until it reaches its final location anterior to the trachea. 9 In this way, it maintains its anchorage to the base of the tongue through the thyroglossal duct until the fifth week of gestation, when it begins to degenerate around the eighth week.…”

Section: Discussionmentioning

confidence: 99%

“…9 Subsequently, it begins its descent from the cecum foramen (base of the tongue), creating a thyroid diverticulum posterior and caudal to the hyoid bone, until it reaches its final location anterior to the trachea. 9 In this way, it maintains its anchorage to the base of the tongue through the thyroglossal duct until the fifth week of gestation, when it begins to degenerate around the eighth week.…”

Section: Discussionmentioning

confidence: 99%

Papillary carcinoma affecting a lateral thyroglossal cyst duct and thyroid: a case report

Dávila,

Villaroel,

Coello

et al. 2023

JOENTR

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“…However, some patients can have mixed (8%) or squamous cell carcinoma (6%). Follicular and anaplastic carcinomas develop even more rarely [2].…”

Section: Figure 1 -Pathohistological Examination Of the Tgdc Showed A...mentioning

confidence: 99%

“…Nevertheless, in 7% of patients, it remains as a cyst, duct, or ectopic tissue. Genetic factors are believed to be the leading cause of TGDC [2].…”

Section: Introduction / вступmentioning

confidence: 99%

Papillary Carcinoma of the Thyroglossal Duct Cyst: A Case Report

Duzhyi

Kononenko

Moskalenko

et al. 2023

EUMJ

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Introduction. Thyroglossal duct cysts (TGDCs) can be diagnosed at any age. They are most common in women aged 30–40. Cysts can become malignant in 1% of patients. As a result, a very rare tumor – TGDC carcinoma ¬– develops. Some oncologists believe it is sufficient to perform surgery using the Sistrunk procedure. Other scientists insist on performing the Sistrunk procedure followed by thyroidectomy, lymph node dissection, and radioactive iodine ablation. In this report, we would like to share our successful experience in treating a patient with papillary carcinoma of PCOS. Case report. A 47-year-old woman had persistent midline neck swelling for three years. This lesion was completely asymptomatic. The patient had no cases of head and neck irradiation or a family history of thyroid gland diseases. Physical examination revealed a solid, movable, smooth mass measuring 6.0 × 5.0 × 4.0 cm on the anterior surface of the neck. The thyroid gland was of normal size, without nodules. Lymph nodes of the neck were not enlargement. During sticking out the tongue and swallowing, the tumor moved upwards. Neck ultrasound, CT scan, and fine-needle aspiration biopsy confirmed the presence of TGDC papillary carcinoma. All laboratory results, including thyroid hormones, were within normal ranges. The patient underwent the Sistrunk procedure, total thyroidectomy with central lymph node dissection, radioactive iodine ablation, and suppression of thyroid function with levothyroxine. The patient's follow-up period has been currently 110 months. There were no signs of relapse. Discussion. The etiology of the malignant transformation of the TGDC remains unknown. One of the main theories is the spontaneous development of ectopic thyroid tissue located in the cyst walls. Ultrasound, CT, and MRI are considered sufficiently informative methods. A fine-needle aspiration biopsy confirms TGDC carcinoma in 53% of patients before surgery. Virtually all patients with TGDC carcinomas undergo the Sistrunk procedure. In addition, some of them perform a total thyroidectomy. Criteria for total thyroidectomy are age older than 45 years, history of neck irradiation, tumor size greater than 4 cm, presence of regional metastases, and thyroid gland dysfunction. Postoperative radioiodine ablation and suppressive levothyroxine therapy are considered the best treatment before the start of the follow-up period. Conclusions. The treatment of patients with TGDC carcinomas should be personalized. Determining criteria should be the patient's age, gender, condition of the thyroid gland and regional lymph nodes, size of the primary tumor, resection margins, invasion of the tumor into the surrounding tissues, and family history of thyroid diseases.

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Papillary carcinoma arising from a thyroglossal duct cyst: A case report and literature review

Cited by 8 publications

References 10 publications

Individual treatment strategy of thyroglossal duct cyst carcinoma: a case report

Individual treatment strategy of thyroglossal duct cyst carcinoma: a case report

Papillary carcinoma affecting a lateral thyroglossal cyst duct and thyroid: a case report

Papillary Carcinoma of the Thyroglossal Duct Cyst: A Case Report

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