Papillary and mucoepidermoid carcinoma of the thyroid with anaplastic transformation

Cameselle-Teijeiro, José; Febles-Pérez, Carmen; Sobrinho-Simões, Manuel

doi:10.1016/s0344-0338(11)81129-5

Cited by 77 publications

(24 citation statements)

References 17 publications

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“…In most of these, tumours NSE positivity seems to reflect an unusual metabolic state of the tumour cells rather than neuroendocrine differentiation [4,33]. The demonstration of other neuroendocrine markers (chromogranins A and B, secretogranin II, synaptophysin) in the four tumours of this series confirmed their true neuroendocrine nature.…”

Section: Discussionmentioning

confidence: 52%

”Atypical" medullary thyroid carcinoma with little or no calcitonin expression

Schmid

Ensinger

1998

Virchows Archiv

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In a retrospective analysis of 142 medullary thyroid carcinomas, four sporadic cases with an unusual histological and immunohistochemical appearance were found. Three cases (two males, one female) had very few calcitonin-positive tumour cells, while the fourth case (male) completely lacked calcitonin immunoreactivity at both mRNA and protein levels, whereas a variety of neuroendocrine markers were positive in at least 50% of tumour cells. The four tumours were completely devoid of carcinoembryonic antigen expression and of amyloid. Differential diagnosis and histogenetic considerations are discussed.

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Section: Discussionmentioning

confidence: 52%

”Atypical" medullary thyroid carcinoma with little or no calcitonin expression

Schmid

Ensinger

1998

Virchows Archiv

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“…Although it has been described as indolent tumors with low-grade malignant potential, some reports have indicated a less favorable behavior of combined other type of carcinoma, especially with foci of undifferentiated carcinoma (19, 20). Our patient presented with combined follicular variant of papillary carcinoma and MEC and metastatic foci in cervical lymph nodes were exclusively MEC.…”

Section: Discussionmentioning

confidence: 99%

Composite Follicular Variant of Papillary Carcinoma and Mucoepidermoid Carcinoma of Thyroid Gland: A Case Report

Jung

Kang

2010

J Korean Med Sci

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A 50-yr-old male presented a thyroid mass with dysphasia and hoarseness. He underwent total thyroidectomy and neck node dissection. Pathologically, the tumor had two distinct tumor components with intermingled areas: follicular variant of papillary carcinoma and mucoepidermoid carcinoma. Mucoepidermoid carcinoma composed of columnar cells, mucocytes, and squamoid cells showing solid and cystic lesion. Several small cysts lined by benign ciliated columnar epithelia suggesting that this tumor had originated from solid cell nest were seen around the tumor. By immunohistochemistry, columnar cells and squamoid cells in mucoepidermoid carcinoma were positive for cytokeratin but negative for thyroglobulin, TTF-1 and calcitonin. Positivity of p63 was seen in squamoid cells and basal cells of cysts. Some mucocytes are CEA positive. Tumor cells of papillary carcinoma are positive for TTF-1, thyroglobulin but negative for CEA, calcitonin and p63.

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“…p63 is a highly specific marker for SCNs, and its expression is frequently associated with Hashimoto’s thyroiditis and papillary thyroid carcinomas (78–80). Taken together, it was proposed that SCNs may represent a pool of stem cells that could contribute to the histogenesis of C cells and follicular cells, and to thyroid lesions as described above (77–80, 82). …”

Section: Solid Cell Nestmentioning

confidence: 94%

“…SCNs are composed of two cell types; “main cells” of polygonal or elongated shape with abundant eosinophilic cytoplasm and round-to-oval nuclei, and “C cells.” Some SCNs contained so-called “mixed follicles,” the structure lined by main cells and follicular epithelium with colloid and/or clumps of eosinophilic materials in the lumen (77–80). SCNs are often found associated with Hashimoto’s thyroiditis, a subset of papillary thyroid carcinomas, and rare tumors such as mucoepidermoid and squamous carcinomas of thyroid (77–80, 82). …”

Section: Solid Cell Nestmentioning

confidence: 99%

Thyroid Regeneration: How Stem Cells Play a Role?

Kimura

2014

Front. Endocrinol.

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Many tissues if not all are thought to contain stem cells that are responsible for regeneration and repair of the tissue after injury. Dysregulation of tissue regeneration may result in various pathological conditions, among which cancer is the most extensively studied. Notably, the so-called cancer stem cells or tumor-initiating cells, have been studied in order to understand the mechanisms of carcinogenesis and/or metastasis. However, the nature of cancer stem cells, let alone normal stem/progenitor cells, particularly those of the thyroid remains elusive. There remains a gap in knowledge between adult thyroid stem/progenitor cells and cancer stem cells of the thyroid, and if and/or how they are related to each other. Understanding of the mechanism for thyroid regeneration and mode of participation of normal adult thyroid stem/progenitor cells in this process will hopefully yield a more complete understanding of the nature of thyroid cancer stem cells, and/or help understand the pathogenesis of other thyroid diseases. This review summarizes the current understanding of adult thyroid stem/progenitor cells, with particular emphasis on how they contribute to thyroid regeneration.

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Papillary and mucoepidermoid carcinoma of the thyroid with anaplastic transformation

Cited by 77 publications

References 17 publications

”Atypical" medullary thyroid carcinoma with little or no calcitonin expression

”Atypical" medullary thyroid carcinoma with little or no calcitonin expression

Composite Follicular Variant of Papillary Carcinoma and Mucoepidermoid Carcinoma of Thyroid Gland: A Case Report

Thyroid Regeneration: How Stem Cells Play a Role?

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