Papillary adenomas of the large intestine. A clinical and morphological study of forty-eight case

Villous papillomata of the large bowel associated with renal failure

“…2, 5 and 6) occur predominantly in men in their fifth or sixth decade of life and account for 2% of all surgically removed neoplasms of the colon (Sunderland & Binkley, 1948;Bacon et al, 1954; ..A.i Mayfield & Milnor, 1959). They are flat, soft, sessile growths of up to 13 cm in diameter and 80% are situated below the recto-sigmoid junction (Wheat & Ackerman, 1958).…”

“…Estimates vary from 6% to 75% (Sunderland & Binkley, 1948;Fisher & Castro, 1953;Wheat & Ackerman, 1958;Mayfield & Milnor, 1959;Diffenbaugh et al, 1964). Biopsy is a quite inadequate form of investigation as any malignant change tends to be focal and a positive result may be obtained in less than 6% of biopsies taken from tumours later proved to be malignant.…”

Surgical management for villous tumors of the rectum

“…A villous tumor is defined as a "flat elevation which macroscopically appears to be superficially villous or to have a fine granular surface, and microscopically as a protrusion which is composed of a villous pattern" [15,17]. They were treated in the Department of Surgery, Tokyo Medical College Kasumigaura Hospital, over the past 10 years.…”

“…A denomas of the large intestine are fairly common and are histologically classified into tubular, villous and tubulo-villous varieties [8]. Villous adenomas occur in the elderly, can undergo malignant transformation, are iarge, and are frequently situated in the lower rectum where sphincter conservation is an important consideration in treatment [15,17],…”

Are Polyps of the Colon Premalignant?

“…Some viewpoints beyond argumentation are: (1) The existence of polyps within the colon does not make them immune to cancer genesis. (2) Mucosa covering a pedunculated polyp of the colon is not immune to cancer development.…”