Paper-based sensors for rapid important biomarkers detection

Kuswandi, Bambang; Hidayat, Moch. Amrun; Noviana, Eka

doi:10.1016/j.biosx.2022.100246

Cited by 19 publications

(11 citation statements)

References 211 publications

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“…Generally, desired detection methods may need different areas of WE, RE, and CE. Various techniques could be used for the patterning of hydrophobic barriers on a paper substrate, e.g., wax, inkjet, laser, flexographic, and screen printing, including other techniques, such as laser treatment, plasma treatment, wet etching, and photolithography [ 54 ] ( Figure 3 ).…”

Section: Paper Design and Fabricationmentioning

confidence: 99%

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Paper-Based Electrochemical Biosensors for Food Safety Analysis

2022

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Nowadays, foodborne pathogens and other food contaminants are among the major contributors to human illnesses and even deaths worldwide. There is a growing need for improvements in food safety globally. However, it is a challenge to detect and identify these harmful analytes in a rapid, sensitive, portable, and user-friendly manner. Recently, researchers have paid attention to the development of paper-based electrochemical biosensors due to their features and promising potential for food safety analysis. The use of paper in electrochemical biosensors offers several advantages such as device miniaturization, low sample consumption, inexpensive mass production, capillary force-driven fluid flow, and capability to store reagents within the pores of the paper substrate. Various paper-based electrochemical biosensors have been developed to enable the detection of foodborne pathogens and other contaminants that pose health hazards to humans. In this review, we discussed several aspects of the biosensors including different device designs (e.g., 2D and 3D devices), fabrication techniques, and electrode modification approaches that are often optimized to generate measurable signals for sensitive detection of analytes. The utilization of different nanomaterials for the modification of electrode surface to improve the detection of analytes via enzyme-, antigen/antibody-, DNA-, aptamer-, and cell-based bioassays is also described. Next, we discussed the current applications of the sensors to detect food contaminants such as foodborne pathogens, pesticides, veterinary drug residues, allergens, and heavy metals. Most of the electrochemical paper analytical devices (e-PADs) reviewed are small and portable, and therefore are suitable for field applications. Lastly, e-PADs are an excellent platform for food safety analysis owing to their user-friendliness, low cost, sensitivity, and a high potential for customization to meet certain analytical needs

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Section: Paper Design and Fabricationmentioning

confidence: 99%

“… Patterning techniques that can be used for e-PAD biosensors, adopted from reference [ 54 ]. Open Access under CC BY-NC.…”

Section: Figurementioning

confidence: 99%

Paper-Based Electrochemical Biosensors for Food Safety Analysis

2022

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“…It should be noted that the field of paper-based sensors is developing rapidly, and significant progress has been made in the development of such sensors. At present, quite a lot of reviews on paper-based sensors have already been published [ 26 , 28 , 29 , 30 , 31 , 32 , 33 , 34 , 35 , 36 , 37 , 38 , 39 , 40 , 41 , 42 , 43 , 44 , 45 , 46 , 47 , 48 , 49 , 50 , 51 , 52 , 53 , 54 , 55 , 56 , 57 ]. But most of them are aimed at considering electrochemical and optical sensors, biosensors, gas sensors, and strain sensors.…”

Section: Introductionmentioning

confidence: 99%

Paper-Based Humidity Sensors as Promising Flexible Devices: State of the Art: Part 1. General Consideration

Korotcenkov

2023

Nanomaterials

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In the first part of the review article “General considerations” we give information about conventional flexible platforms and consider the advantages and disadvantages of paper when used in humidity sensors, both as a substrate and as a humidity-sensitive material. This consideration shows that paper, especially nanopaper, is a very promising material for the development of low-cost flexible humidity sensors suitable for a wide range of applications. Various humidity-sensitive materials suitable for use in paper-based sensors are analyzed and the humidity-sensitive characteristics of paper and other humidity-sensitive materials are compared. Various configurations of humidity sensors that can be developed on the basis of paper are considered, and a description of the mechanisms of their operation is given. Next, we discuss the manufacturing features of paper-based humidity sensors. The main attention is paid to the consideration of such problems as patterning and electrode formation. It is shown that printing technologies are the most suitable for mass production of paper-based flexible humidity sensors. At the same time, these technologies are effective both in the formation of a humidity-sensitive layer and in the manufacture of electrodes.

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“…[8][9][10][11][12][13][14] Among the various biomarkers in sweat, hydronium ion, the concentration of which is related to pH, is one of the most important markers for monitoring human health. 15 A change in the pH balance of sweat or blood indicates certain health conditions and medical emergencies including infection, asthma, diabetes, kidney disease, lung disease, and heart disease. [16][17][18][19] The pH of a solution can be detected in various ways, such as using litmus paper, image sensors, optical fiber sensors, conductometric sensors, and potentiometric sensors.…”

Section: Introductionmentioning

confidence: 99%

“…To date, several wearable sweat sensors have been explored to monitor sweat analytes, which include wearable patches, skin tattoos, screen‐printed sensors, textile‐based sensors, and eyeglasses 8–14 . Among the various biomarkers in sweat, hydronium ion, the concentration of which is related to pH, is one of the most important markers for monitoring human health 15 . A change in the pH balance of sweat or blood indicates certain health conditions and medical emergencies including infection, asthma, diabetes, kidney disease, lung disease, and heart disease 16–19 .…”

Section: Introductionmentioning

confidence: 99%

Preparation of nanopillar array electrode of iridium oxide for high performance of pH sensor and its real‐time sweat monitoring

Yoon

Park

Kil

et al. 2023

Bulletin Korean Chem Soc

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A highly sensitive potentiometric pH sensor was developed based on nanopillar array electrodes of iridium oxide. The as‐prepared pH sensor exhibited a high pH sensitivity (69.43 mV/pH), fast response time (8.1 s), and good durability (0.76 mV/h). The sensing performance of the pH sensor was maintained under mechanical bending and even after 1000 repetitive bending/releasing cycles. As a proof‐of‐concept, a wearable headband sensor was fabricated by integrating the pH sensor with a wireless electronic module based on a printed circuit board. The on‐body test indicated that the wearable pH sensor provides reliable and stable data in the real‐time monitoring of pH changes in human sweat during stationary indoor cycling. The pH sensors based on nanopillar array electrodes of iridium oxide have great potential in many portable or wearable applications in healthcare systems, non‐invasive diagnostics, environmental analysis, and food sensors.

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Paper-based sensors for rapid important biomarkers detection

Cited by 19 publications

References 211 publications

Paper-Based Electrochemical Biosensors for Food Safety Analysis

Paper-Based Electrochemical Biosensors for Food Safety Analysis

Paper-Based Humidity Sensors as Promising Flexible Devices: State of the Art: Part 1. General Consideration

Preparation of nanopillar array electrode of iridium oxide for high performance of pH sensor and its real‐time sweat monitoring

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