Paper-Based Preconcentration and Isolation of Microvesicles and Exosomes

Lee, Dohwan; Wee, Kyung Wook; Kim, Hyerin; Han, Sung Il; Kwak, Seungmin; Yoon, Dae Sung

doi:10.3791/61292

Cited by 2 publications

(1 citation statement)

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“…Ultrasonication of MSCs for 1 min also improved the EV yield, which exhibited ∼20-fold higher and ∼100-fold faster production than the natural secretion 250 . A recent study described a detailed method to fabricate an origami-paper-based device that integrated the ion concentration polarization technique for effective enrichment and isolation of EVs in a simple manner 251 . Further, engineered EVs showed promising roles in this field.…”

Section: Challenges and Future Directionsmentioning

confidence: 99%

Extracellular vesicles in Inflammatory Skin Disorders: from Pathophysiology to Treatment

Shao¹,

Fang²,

Li³

et al. 2020

Theranostics

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Extracellular vesicles (EVs), naturally secreted by almost all known cell types into extracellular space, can transfer their bioactive cargos of nucleic acids and proteins to recipient cells, mediating cell-cell communication. Thus, they participate in many pathogenic processes including immune regulation, cell proliferation and differentiation, cell death, angiogenesis, among others. Cumulative evidence has shown the important regulatory effects of EVs on the initiation and progression of inflammation, autoimmunity, and cancer. In dermatology, recent studies indicate that EVs play key immunomodulatory roles in inflammatory skin disorders, including psoriasis, atopic dermatitis, lichen planus, bullous pemphigoid, systemic lupus erythematosus, and wound healing. Importantly, EVs can be used as biomarkers of pathophysiological states and/or therapeutic agents, both as carriers of drugs or even as a drug by themselves. In this review, we will summarize current research advances of EVs from different cells and their implications in inflammatory skin disorders, and further discuss their future applications, updated techniques, and challenges in clinical translational medicine.

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Section: Challenges and Future Directionsmentioning

confidence: 99%