Paper based microfluidics: A forecast toward the most affordable and rapid point-of-care devices

Sinha, Anirban; Basu, Mainak; Chandna, P.

doi:10.1016/bs.pmbts.2021.07.010

Cited by 8 publications

(4 citation statements)

References 156 publications

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“…Nowadays, paper is considered an attractive and promising platform for analytical applications. Paper consists of a network of randomly interwoven cellulose fibers in a 2-dimensional sheet format [ 10 , 11 , 12 , 13 ]. The fibrous and porous structure of cellulose confers some important advantages that make paper an excellent candidate as an analytical platform [ 14 ].…”

Section: Paper-based Devicesmentioning

confidence: 99%

“…Two general methodologies have been applied for the fabrication of PADs: two-dimensional shaping/cutting and patterning hydrophilic/hydrophobic areas [ 10 , 11 , 12 , 13 , 14 , 24 ]. In the first methodology, the paper channels are generally obtained by cutting the paper manually, with an X-Y cutter/plotter, or with a CO 2 laser cutting apparatus.…”

Section: Paper-based Devicesmentioning

confidence: 99%

“…Theoretical and practical aspects regarding the operation of PADs (such as liquid flow, flow control, surface modification, etc.) are discussed in several reviews [ 10 , 11 , 12 , 13 , 27 , 28 , 29 ].…”

Section: Paper-based Devicesmentioning

confidence: 99%

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Paper-Based Aptasensors: Working Principles, Detection Modes, and Applications

Economou,

Kokkinos,

Bousiakou

et al. 2023

Sensors

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Aptamers are short oligonucleotides designed to possess high binding affinity towards specific target compounds (ions, molecules, or cells). Due to their function and unique advantages, aptamers are considered viable alternatives to antibodies as biorecognition elements in bioassays and biosensors. On the other hand, paper-based devices (PADs) have emerged as a promising and powerful technology for the fabrication of low-cost analytical tools, mainly intended for on-site and point-of-care applications. The present work aims to provide a comprehensive overview of paper-based aptasensors. The review describes the fabrication methods and working principles of paper-based devices, the properties of aptamers as bioreceptors, the different modes of detection used in conjunction with aptasensing PADs, and representative applications for the detection of ions, small molecules, proteins, and cells. The future challenges and prospects of these devices are also discussed.

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Section: Paper-based Devicesmentioning

confidence: 99%

Section: Paper-based Devicesmentioning

confidence: 99%

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Paper-Based Aptasensors: Working Principles, Detection Modes, and Applications

Economou,

Kokkinos,

Bousiakou

et al. 2023

Sensors

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show abstract

“…Capillary action, caused by the surface tension of the liquid in a porous medium, pushes fluid within paper without the need for a power source. μPADs are regarded as an effective POCT (Sinha, Basu et al, 2022), tool since they imply the advantages of paper as a substrate that are environmentally benign and practicable, making them a unique material that is simpler to dispose of safely (Agarwal, Csóka et al, 2019). (µPADs) have several practical benefits including cheaper cost, a simple production method, robust capillary action, and high biological compatibility (Fu and Wang 2018), (Hsu, Liu et al, 2019) with applications in biomedical diagnostics, analytical chemistry, food quality control and environmental sensing.…”

Section: Introductionmentioning

confidence: 99%

A New Paper-Based Microfluidic Design (µPAD) for Determination of Total Phenols and Biological Applications Using Smartphone Sensor as a Detector

Rashed,

Hussein

2023

Egyptian Academic Journal of Biological Sciences. C, Physiology

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Phenols are well-known noxious compounds, which are often found in various water sources. In this research, a new method was used to determine the total phenol and measure the biological activity, by using the microfluidic paper-based (µPAD), smartphone Sensor. It is portable, low-cost, and environmentally friendly. The paper was prepared using filter paper by cutting method. The reagent was dried on the paper. The color sensor of the smartphone device was used as the color intensity sensor of the samples through the images captured by the smartphone through software downloaded to the phone. The focus of the samples is measured from the RGB value of the images taken from the (iPhone 14) device, where each image represents a specific focus. The calibration curve for this method was in the range of M (0.00016-0.5), the correlation coefficient (R2) was equal to (0.9753), the limit of detection was in the amount of (0.000032) M, and the relative standard deviation (RSD%) for the concentration is (0.02) M, for which the examination was repeated (10) times and its value was (0 %), and the recovery value (Recovery%) was equal to (100 %).

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Editable Au NCs@ZIF-8 nanomaterial-modified paper in situ as well as portable smartphone-assisted sensing assay for the highly sensitive Cu (II) detection in Wilson’s disease

Wang

Hong

et al. 2023

Sensors and Actuators B: Chemical

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Paper based microfluidics: A forecast toward the most affordable and rapid point-of-care devices

Cited by 8 publications

References 156 publications

Paper-Based Aptasensors: Working Principles, Detection Modes, and Applications

Paper-Based Aptasensors: Working Principles, Detection Modes, and Applications

A New Paper-Based Microfluidic Design (µPAD) for Determination of Total Phenols and Biological Applications Using Smartphone Sensor as a Detector

Editable Au NCs@ZIF-8 nanomaterial-modified paper in situ as well as portable smartphone-assisted sensing assay for the highly sensitive Cu (II) detection in Wilson’s disease

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