Paper-based analytical device for sampling, on-site preconcentration and detection of ppb lead in water

Satarpai, Thiphol; Shiowatana, Juwadee; Siripinyanond, Atitaya

doi:10.1016/j.talanta.2016.04.017

Cited by 72 publications

(36 citation statements)

References 42 publications

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“…Three main methods were used for patterning paper: photolithography using a suitable resist such as SU-8, [18][19][20] wax printing, [21][22][23] and inkjet printing. [24][25][26] These methods produce micro patterns on the paper device with high resolution, but they all require additional materials to be involved in the process.…”

Section: Introductionmentioning

confidence: 99%

Disposable Paper-on-CMOS Platform for Real-Time Simultaneous Detection of Metabolites

Annese

Velugotla

et al. 2020

IEEE Trans. Biomed. Eng.

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Objective: Early stage diagnosis of sepsis without overburdening health services is essential to improving patient outcomes. Methods: A fast and simple-to-use platform that combines an integrated circuit with paper microfluidics for simultaneous detection of multiple-metabolites appropriate for diagnostics was presented. Paper based sensors are a primary candidate for widespread deployment of diagnostic or test devices. However, the majority of devices today use a simple paper strip to detect a single marker using the reflectance of light. However, for many diseases such as sepsis, one biomarker is not sufficient to make a unique diagnosis. In this work multiple measurements are made on patterned paper simultaneously. Using laser ablation to fabricate microfluidic channels on paper provides a flexible and direct approach for mass manufacture of disposable paper strips. A reusable photodiode array on a complementary metal oxide semiconductor chip is used as the transducer. Results: The system measures changes in optical absorbance in the paper to achieve a cost-effective and easily implemented system that is capable of multiple simultaneous assays. Potential sepsis metabolite biomarkers glucose and lactate have been studied and quantified with the platform, achieving sensitivity within the physiological range in human serum. Conclusion: We have detailed a disposable paper-based CMOS photodiode sensor platform for real-time simultaneous detection of metabolites for diseases such as sepsis. Significance: A combination of a low-cost paper strip with microfluidic channels and a sensitive CMOS photodiode sensor array makes our platform a robust portable and inexpensive

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Section: Introductionmentioning

confidence: 99%

Disposable Paper-on-CMOS Platform for Real-Time Simultaneous Detection of Metabolites

Annese

Velugotla

et al. 2020

IEEE Trans. Biomed. Eng.

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“…A batch preconcentration method was also coupled with a PAD for determining lead ions in water samples, and a peristaltic pump was required to flow a sample solution, which means a battery would be required for the preconcentration process. 33 As the use of the preconcentration method demonstrates, expanding the analytical technique via the implementation of continuous-flow PADs is challenging. This explains why examples of continuous flow are limited in the literature, whereas there are many reports on delayed flow using PADs.…”

Section: Introductionmentioning

confidence: 99%

Highly Sensitive Paper-based Analytical Devices with the Introduction of a Large-Volume Sample via Continuous Flow

Shimada

Kaneta

2018

ANAL. SCI.

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The implementation of continuous flow in paper-based analytical devices (PADs) was challenging because of the largevolume introduction that was created; but this allowed for the development of novel types of PADs for preconcentration, separation, and sensitive detection. In this study, pump-free continuous flow was applied to a distance-based PAD for the determination of iron ions. Continuous flow enabled the introduction of a volume that exceeded what was necessary to fill the hydrophilic channel of a PAD. Thus, this continuous-flow method significantly improved both the limits of detection (LOD) and the limits of quantification (LOQ) for a distance-based PAD by increasing the sample volume that could be introduced into the PAD. The values for LOD and LOQ were 20 and 26 ppb, respectively, which were more than 150-times lower than that obtained using a small sample volume (50 μL), and were comparable to those of inductively coupled plasma-atomic emission spectrometry. The continuous-flow technique was applicable to the determination of iron ions at levels of several tens of ppb in natural water without preconcentration.

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“…Since the contaminations usually exist at a relatively low concentration, the preconcentration and purification of analytes from natural matrix are necessary steps before instrumental analysis. Up to now, significant efforts have been devoted to the development of suitable sample pretreatment technologies for on‐site sampling . SPME is an effective approach for on‐site sampling due to its advantages of high enrichment factor, simple operation, and solvent‐free process .…”

Section: Introductionmentioning

confidence: 99%

Metal–organic framework based in‐syringe solid‐phase extraction for the on‐site sampling of polycyclic aromatic hydrocarbons from environmental water samples

Zhang

Wang

Han

et al. 2018

J of Separation Science

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In-syringe solid-phase extraction is a promising sample pretreatment method for the on-site sampling of water samples because of its outstanding advantages of portability, simple operation, short extraction time, and low cost. In this work, a novel in-syringe solid-phase extraction device using metal-organic frameworks as the adsorbent was fabricated for the on-site sampling of polycyclic aromatic hydrocarbons from environmental waters. Trace polycyclic aromatic hydrocarbons were effectively extracted through the self-made device followed by gas chromatography with mass spectrometry analysis. Owing to the excellent adsorption performance of metal-organic frameworks, the analytes could be completely adsorbed during one adsorption cycle, thus effectively shortening the extraction time. Moreover, the adsorbed analytes could remain stable on the device for at least 7 days, revealing the potential of the self-made device for on-site sampling of degradable compounds in remote regions. The limit of detection ranged from 0.20 to 1.9 ng/L under the optimum conditions. Satisfactory recoveries varying from 84.4 to 104.5% and relative standard deviations below 9.7% were obtained in real samples analysis. The results of this study promote the application of metal-organic frameworks in sample preparation and demonstrate the great potential of in-syringe solid-phase extraction for the on-site sampling of trace contaminants in environmental waters.

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Paper-based analytical device for sampling, on-site preconcentration and detection of ppb lead in water

Cited by 72 publications

References 42 publications

Disposable Paper-on-CMOS Platform for Real-Time Simultaneous Detection of Metabolites

Disposable Paper-on-CMOS Platform for Real-Time Simultaneous Detection of Metabolites

Highly Sensitive Paper-based Analytical Devices with the Introduction of a Large-Volume Sample via Continuous Flow

Metal–organic framework based in‐syringe solid‐phase extraction for the on‐site sampling of polycyclic aromatic hydrocarbons from environmental water samples

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