Papel pronóstico de la hipertensión arterial y de la diabetes mellitus en los pacientes con angina inestable tratados con stents coronarios

López-Mínguez, José Ramón; Fuentes, María Eugenia; Doblado, Manuel; Merchán, Antonio Guerra; Martínez, Antonio; González, Ricardo; Alonso, Rafael; Alonso, Francisco

doi:10.1016/s0300-8932(03)76996-6

Cited by 12 publications

(2 citation statements)

References 41 publications

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“…Hypertension did not affect short-and long term mortality in patients with ST elevation myocardial infarction (STEMI) receiving PCI [2, 3]. However, hypertension was the only independent long-term predictor of mortality in patients with unstable angina (US) receiving coronary stenting [4]. Insulin-treated diabetes mellitus (ITDM) was a strong predictor for long-term mortality when compared with non-DM or non-ITDM patients [5].…”

Section: Introductionmentioning

confidence: 99%

Impact of diabetes and hypertension on cardiovascular outcomes in patients with coronary artery disease receiving percutaneous coronary intervention

Lin

Chen

Lin

et al. 2017

BMC Cardiovasc Disord

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BackgroundPercutaneous coronary intervention (PCI) is a necessary procedure commonly performed for patients with coronary artery disease (CAD). However, the impact of diabetes and hypertension on long-term outcomes of patients after receiving PCI has not yet been determined.MethodsThe data of 1234 patients who received PCI were collected prospectively, and patients were divided into four groups, including patients with and without DM and those with either DM or hypertension alone. Baseline characteristics, risk factors, medications and angiographic findings were compared and determinants of cardiovascular outcomes were analyzed in patients who received PCI.ResultsPatients with DM alone had the highest all-cause mortality (P < 0.001), cardiovascular mortality and myocardial infarctions (MI) (both P < 0.01) compared to the other groups. However, no differences were found between groups in repeat PCI (P = 0.32). Cox proportional hazard model revealed that age, chronic kidney disease (CKD), previous MI and stroke history were risk factors for all-cause mortality (OR: 1.05,1.89, 2.87, and 4.12, respectively), and use of beta-blockers (BB) and statins reduced all-cause mortality (OR: 0.47 and 0.35, respectively). Previous MI and stroke history, P2Y12 inhibitor use, and syntax scores all predicted CV mortality (OR: 4.02, 1.89, 2.87, and 1.04, respectively). Use of angiotensin converting enzyme inhibitors (ACEI), beta-blockers (BB), and statins appeared to reduce risk of CV death (OR: 0.37, 0.33, and 0.32, respectively). Previous MI and syntax scores predicted MI (OR: 3.17 and 1.03, respectively), and statin use reduced risk of MI (OR: 0.43). Smoking and BB use were associated with repeat PCI (OR: 1.48 and 1.56, respectively).ConclusionsAfter PCI, patients with DM alone have higher mortality compared to patients without DM and hypertension, with both DM and hypertension, and with hypertension alone. Comorbid hypertension does not appear to increase risk in DM patients, whereas comorbid DM appears to increase risk in hypertensive patients.Trial registrationREC103-15 IRB of Taichung Tzu-chi Hospital

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Section: Introductionmentioning

confidence: 99%

Impact of diabetes and hypertension on cardiovascular outcomes in patients with coronary artery disease receiving percutaneous coronary intervention

Lin

Chen

Lin

et al. 2017

BMC Cardiovasc Disord

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“…Nevertheless, several risk factors affect long-term outcome after PCI. Diabetes mellitus (DM) and hypertension (HT) are significant risk factors that affect outcomes in CAD patients undergoing PCI 1 – 3 . Recently, chronic kidney disease (CKD) has been regarded as a new risk factor associated with outcomes in patients undergoing PCI 4 – 6 .…”

Section: Introductionmentioning

confidence: 99%

Hypertension and chronic kidney disease affect long-term outcomes in patients with stable coronary artery disease receiving percutaneous coronary intervention

Lin

Yang

Chen

et al. 2018

Sci Rep

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Percutaneous coronary intervention (PCI) is commonly used for patients with coronary artery disease (CAD). However, the effects of chronic kidney disease (CKD) and hypertension (HT) on long-term outcomes in patients with stable CAD receiving PCI are still unclear. A total of 1,676 patients treated with PCI were prospectively enrolled and divided into 4 groups according to the presence or absence of HT or CKD. General characteristics, clinical medications, risk factors, angiographic findings, and long-term outcomes were analyzed. Patients with CKD had the highest rate of all-cause and cardiovascular (CV) mortality (both P < 0.01). Patients with CKD alone had the lowest event-free rate of all-cause and CV deaths (both P < 0.001). Based on Cox proportional hazard model, patients with CKD alone had the highest risk of all-cause death (HR:2.86, 95% CI:1.73–4.75) and CV death (HR: 3.57,95% CI:2.01–6.33); while patients with both CKD and HT had the highest risk of repeat PCI (HR: 1.42, 95% CI:1.09–1.85).We found that in stable CAD patients after undergoing PCI, those with CKD alone had the highest long-term mortality. Comorbid CKD appears to increase risk in patient with HT, whereas comorbid HT doesn’t seem to increase risk in patients with CKD.

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Abciximab offers greater benefits to insulin-dependent diabetic patients undergoing coronary stent implantation

López-Mínguez

Nogales

González

et al. 2007

Cardiovascular Revascularization Medicine

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Papel pronóstico de la hipertensión arterial y de la diabetes mellitus en los pacientes con angina inestable tratados con stents coronarios

Cited by 12 publications

References 41 publications

Impact of diabetes and hypertension on cardiovascular outcomes in patients with coronary artery disease receiving percutaneous coronary intervention

Impact of diabetes and hypertension on cardiovascular outcomes in patients with coronary artery disease receiving percutaneous coronary intervention

Hypertension and chronic kidney disease affect long-term outcomes in patients with stable coronary artery disease receiving percutaneous coronary intervention

Abciximab offers greater benefits to insulin-dependent diabetic patients undergoing coronary stent implantation

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