Papel de la nitroglicerina tópica en la supervivencia de colgajos con sufrimiento cutáneo

Efecto protector del unguento de nitroglicerina y el dimetilsulfoxido en la necrosis de colgajos cutáneos en ratas

“…In clinical practice, the use of NTG ointment has been found useful to improve the survival of flaps 5,8,17,19,20 , these studies looked at flaps based on random circulation, where flap circulation is from capillaries and not from a main pedicle. In the case of axial microvascular flaps, where distress is mainly due to problems with the vascular pedicle, either at the level of the anastomosis or farther away due to torsion or kinking, the use of NTG ointment will not be useful, and the indication to reexamine the flap is the best salvage option.…”

“…The main challenge is in the distal areas of the flap, which suffer from a decreased supply, generating tissue ischemia 1 . Nitric oxide acts as a tissue protector by inhibiting aggregation of thrombocytes, leukocyte adhesion to the endothelium, eradicating free radicals, maintaining vascular permeability, regulating vascular tone, and stimulating the regeneration of vascular endothelium, among others [2][3][4][5][6][7] .…”