Papel de la grelina y la leptina en el comportamiento alimentario: evidencias genéticas y moleculares

Espinoza-García, Astrid Selene; Moreno, Alma Gabriela Martínez; Reyes-Castillo, Zyanya

doi:10.1016/j.endinu.2020.10.011

Cited by 11 publications

(14 citation statements)

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“…It will be based on the user-centered methodology (28) and on the guide for the development and evaluation of digital behavior interventions in the healthcare https://doi.org/10.1017/S0007114523000843 Published online by Cambridge University Press (23) . It will contain the following behavior change techniques: education and instructions on how to perform a behavior through workshops and recipes videos (17,29) ; persuasion by sending messages of risks and benefits (information about health and environmental consequences) (29,30) , encouragement and coercion using token economy (17) , nudges by messaging (31) , self-monitoring by graphical progress viewing (32,33) , successive approaches by behavioral objectives addressing (17) , social support by a chat and a forum for the participants to share pictures, comments, and doubts (34) , and guides (18) , through a sustainable food guide that will be designed employing linear programming optimization (35,36) using MATLAB® and Python®, and graphic design programs such as Canva®, Adobe Illustrator®, and BioRender®. This guide will be created based on the recommendations of the FAO for the development of dietary guidelines (37) and the Mexican Food Equivalent System (38) .…”

Section: Mobile Application Designmentioning

confidence: 99%

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Sustainable-psycho-nutritional intervention programme for a sustainable diet (the ‘NutriSOS’ study) and its effects on eating behaviour, diet quality, nutritional status, physical activity, metabolic biomarkers, gut microbiota and water and carbon footprints in Mexican population: study protocol of an mHealth randomised controlled trial

et al. 2023

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Mexico is going through an environmental and nutritional crisis related to unsustainable dietary behaviors. Sustainable diets could solve both problems together. This study protocol aims to develop a 3-stages, 15 weeks mHealth randomized controlled trial (RCT) of a sustainable-psycho-nutritional intervention program to promote Mexican population adherence to a sustainable diet and to evaluate its effects on health and environmental outcomes. In stage 1, the program will be designed using the sustainable diets, behavior change wheel, and COM-B models. A sustainable food guide, recipes, meal plans, and a mobile application will be developed. In stage 2, the intervention will be implemented for seven weeks, and a 7-weeks follow-up period in a young Mexican adults (18 to 35 years) sample, randomly divided (1:1 ratio) into a control group (n=50) and an experimental group (n=50), that will be divided in two arms at week 8. Outcomes will include health, nutrition, environment, behavior, and nutritional-sustainable knowledge. Additionally, socioeconomics and culture will be considered. Thirteen behavioral objectives will be included using successive approaches in online workshops twice a week. The population will be monitored using the mobile application consisting of behavioral change techniques. In stage 3, the effects of the intervention will be assessed using mixed-effect models on dietary intake and quality, nutritional status, physical activity, metabolic biomarkers (serum glucose and lipid profile), gut microbiota composition, and dietary water and carbon footprints of the evaluated population. Improvements in health outcomes and a decrease in dietary water and carbon footprints are expected.

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Section: Mobile Application Designmentioning

confidence: 99%

“…For adopting a particular diet, it is necessary to modify the eating behavior of the population (17)(18)(19) . There are multiple strategies to change dietary and unsustainable behaviors in a population, among which intervention programs based on behavior change techniques have stood out (18,20,21) .…”

Section: Introductionmentioning

confidence: 99%

Sustainable-psycho-nutritional intervention programme for a sustainable diet (the ‘NutriSOS’ study) and its effects on eating behaviour, diet quality, nutritional status, physical activity, metabolic biomarkers, gut microbiota and water and carbon footprints in Mexican population: study protocol of an mHealth randomised controlled trial

et al. 2023

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“…Among biochemical risk factors, hormones involved in the regulation of satiety and hunger have a role in both obesity and EDs [38]. Specifically, ghrelin, an appetizing hormone, and leptin, a promoter of the feeling of satiety, are important factors in weight control [53]. Often associated with obesity, these hormones have also been implicated in the pathophysiology of EDs [53][54][55].…”

Section: Binge Eating Disorder In Adolescents With Obesitymentioning

confidence: 99%

“…Specifically, ghrelin, an appetizing hormone, and leptin, a promoter of the feeling of satiety, are important factors in weight control [53]. Often associated with obesity, these hormones have also been implicated in the pathophysiology of EDs [53][54][55]. Concerning psychological risk factors, low self-esteem, negative self-evaluation, depression, and body dissatisfaction are considered to be contributors to the development of both EDs and obesity [31,44,[56][57][58].…”

Section: Binge Eating Disorder In Adolescents With Obesitymentioning

confidence: 99%

Benefits of Exercise in Multidisciplinary Treatment of Binge Eating Disorder in Adolescents with Obesity

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et al. 2022

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Obesity in childhood and adolescence represents a serious health problem worldwide. Similarly, eating disorders (EDs) are complex diseases that affect adolescents with an increasing prevalence and are an alarming health concern to both physical and mental health. Traditionally, obesity and EDs, particularly binge eating disorder (BED), have been considered separate conditions, but there is emerging evidence such as etiology, comorbidities, risk factors, psychosocial impairment, and prevention approaches, highlighting important overlaps among these conditions. In youth, the two conditions share risk factors and consequences at both the physical and psychological levels, requiring special care. Exercise, useful as strategy to prevent and treat overweight conditions, may have beneficial effects on BED symptoms, suggesting that it may be considered as one of the key factors in the treatment of individuals affected by obesity with BED. The purpose of this narrative review is to examine the bidirectional impact of obesity and BED in adolescents, in terms of risk factors, etiology and comorbid conditions. Specifically, we focused on the benefits of physical activity (PA) in the multidisciplinary treatment of subjects affected by obesity with BED. Even though additional research is needed to reach conclusions about the role of exercise in the treatment of obesity and comorbid BED, especially in adolescents, promising results have already suggested that closely monitored exercise is safe and, paired with cognitive behavioral therapy, may provide multiple benefits on both the physical and psychological levels. Tailored and integrated treatments for weight management and eating disorders are important to promptly and effectively treat obese subjects that have BED.

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“…Ghrelin is the ligand of the growth hormone secretagogue receptor [27] and has both peripheral and central action [28], with a wide array of effects in both physiological and pathological settings [28,29]. Its role is not only linked to energy metabolism and appetite control [30][31][32] but also inflammation and oxidative stress [33,34], the modulation of cardiac activity and post-injury myocardial changes [35,36], stress and anxiety [37,38], anorexia and other psychiatric conditions [39,40], neurodegenerative disorders [41] and sepsis [42,43]. The longstanding contribution of ghrelin to carcinogenesis and tumor progression, especially in GIT malignancies [44,45] has been demonstrated through positive IHC and mRNA expression in endocrine and non-endocrine tumors [46,47] spanning across a multitude of organs and systems [45].…”

Section: Introductionmentioning

confidence: 99%

GIST and Ghrelin: To Be or Not to Be?

et al. 2021

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Background: Ghrelin is the orexigenic hormone secreted mainly by the stomach. Its involvement in neoplastic development has been studied in gastrointestinal adenocarcinomas. Our paper aims to evaluate the influence of the ghrelin axis in gastrointestinal stromal tumors (GISTs). Materials and Methods: The study design included two groups of patients, 46 with gastric GISTs and 30 with obesity. Archived tissue samples were evaluated for the presence of gastritis and H. pylori. Immunohistochemical expression of ghrelin and its receptor (GHS-R) was assessed. Results: All GISTs showed absent immunohistochemical expression for ghrelin, while GHS-R displayed a particular pattern, with notable differences in intensity (p = 0.0256) and percentage of stained cells (p < 0.00001) in the periphery vs. core of tumors. Positive ghrelin expression was lower in the gastric mucosa of the first group compared to the second group (p < 0.001). Conclusion: The ghrelin axis can influence GISTs carcinogenesis through activation of GHS-R. A previously described direct autocrine/paracrine mechanism is not supported by our findings.

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Papel de la grelina y la leptina en el comportamiento alimentario: evidencias genéticas y moleculares

Cited by 11 publications

References 35 publications

Benefits of Exercise in Multidisciplinary Treatment of Binge Eating Disorder in Adolescents with Obesity

GIST and Ghrelin: To Be or Not to Be?

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