Papaverine - induced inhibition of phosphodiesterase activity in various mammalian tissues

Pöch, G.; Kukovetz, W. R.

doi:10.1016/0024-3205(71)90086-5

Cited by 160 publications

(53 citation statements)

References 17 publications

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“…It is well known that papaverine increases intracellular cyclic AMP level by inhibiting the phosphodies terase which hydrolyzes cyclic AMP (16). Recent studies have revealed the existence of a good correlation between papaverine induced smooth muscle relaxation and intra cellular cyclic AMP increase (17)(18)(19)(20).…”

Section: Discussionmentioning

confidence: 99%

Mechanism of Relaxant Action of Papaverine VI. Sodium Ion Dependence of Its Effect on 45Ca-Efflux in Guinea-Pig Taenia Coli

Sunagane

Uruno

Kubota

1985

Japanese Journal of Pharmacology

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Section: Discussionmentioning

confidence: 99%

Mechanism of Relaxant Action of Papaverine VI. Sodium Ion Dependence of Its Effect on 45Ca-Efflux in Guinea-Pig Taenia Coli

Sunagane

Uruno

Kubota

1985

Japanese Journal of Pharmacology

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“…It was also demonstrated that an inhibitory potency of papaverine on PDEase activity of the pre parations from several smooth muscles cor relates closely with its relaxing activity on each muscle (20,21). Carpendo et al (23) reported that papaverine and eupaverine enhance the rate of calcium uptake significantly in the isolated microsomes from rabbit white skeletal muscle.…”

Section: Methodsmentioning

confidence: 95%

“…It has been reported that papaverine inhibits various PDEase activities and increases the intra cellular cyclic AMP level in several kinds of smooth muscles (20)(21)(22).…”

Section: Methodsmentioning

confidence: 99%

A possible mechanism for relaxation of rat uterine smooth muscle by nicardipine hydrochloride (YC-93), a new potent vasodilator.

Nishikori¹,

Takenaka²,

Maeno³

1981

Jpn.J.Pharmacol

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“…The phosphodiesterase involved in cyclic AMP breakdown is reportedly inhibited by theophylline (3), caffeine (3) and papaverine (6,7) and the inhibitory action of papaverine on the phosphodiesterase activity is apparently greater than that of theophylline (6). These data suggest that the actions of beta-stimulants and cyclic AMP are potentiated under treatment with those inhibitors.…”

Section: Effects Of Catecholamines and Cyclic Ampmentioning

confidence: 97%

Further Studies of the Action of Cyclic Amp on the Electrical and Mechanical Activities of Intestinal Smooth Muscle

Ohkawa

1976

Japanese Journal of Pharmacology

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Abstract-Effects of externally applied cyclic AMP and other adrenergic stimulants on the electrical and mechanical activities of the cat small intestine were observed by using pressure electrodes. The electrical and mechanical activities were suppressed by cyclic AMP and beta-stimulants.Those inhibitory actions of cyclic AMP and beta-stimulants were potentiated under the treatment with caffeine, theophylline and papaverine which inhibits the phosphodiesterase activity.On the other hand, the inhibitory action of cyclic AMP and beta-stimulants was decreased in imidazole, an agent that increases phosphodiesterase activity. Exogenous applied concanavalin A, an agent that inhibits the adenyl cyclase activity, showed no observable changes in both activities but the effects of beta-stimulants were decreased after treatment with con canavalin A. No obvious changes on both activities were obtained in cyclic GMP and dibutyryl cyclic GMP. These findings tentatively support the hypothesis that cyclic AMP is a second messenger in the inhibitory responses to beta-stimulants on the intestinal smooth muscle. However, it is also concluded that the inhibition of me chanical activity caused by cyclic AMP is partially due to suppression of the membrane activity.In relation to the relaxation mechanism of smooth muscles, several authors (1, 2, 3) have emphasized two subjects, that is, the activation of adenyl cyclase in cell membrane by beta-adrenergic stimulants and the increase of intracellular level of cyclic 3',5'-adenosine monophosphate (cyclic AMP). In previous papers (4, 5), it has been reported that cyclic AMP and dibutyryl cyclic AMP inhibited the spontaneous electrical and mechanical ac tivities of the intestinal smooth muscle. These actions of cyclic AMP and related compounds may thus possibly relate with adenyl cyclase and phosphodiesterase activity in the smooth muscle. On the other hand, it has been acknowledged that the phosphodiesterase activity is affected by externally applied caffeine (3), theophylline (3), papaverine (6, 7) and imidazole (3) and that adenyl cyclase activity is affected by concanavalin A (8).This report is concerned with the action of cyclic AMP on both activities of intestinal smooth muscle under affecting factors on the enzyme activity. MATERIALS AND METHODSThe small intestine was removed from adult cats which had been anesthetized with isor_ole. For the purpose of recording electrical and mechanical activities, a segment, 3 cm to 3.5 cm long, was slipped onto a rectangular Lucite holder and the holder was mounted in the normal solution at 36-37`-'C in a 200 nil Lucite chamber. One end of the segment was

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Papaverine - induced inhibition of phosphodiesterase activity in various mammalian tissues

Cited by 160 publications

References 17 publications

Mechanism of Relaxant Action of Papaverine VI. Sodium Ion Dependence of Its Effect on 45Ca-Efflux in Guinea-Pig Taenia Coli

Mechanism of Relaxant Action of Papaverine VI. Sodium Ion Dependence of Its Effect on 45Ca-Efflux in Guinea-Pig Taenia Coli

A possible mechanism for relaxation of rat uterine smooth muscle by nicardipine hydrochloride (YC-93), a new potent vasodilator.

Further Studies of the Action of Cyclic Amp on the Electrical and Mechanical Activities of Intestinal Smooth Muscle

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