Papaverine, an opium alkaloid influences hepatic and pulmonary glutathione s-transferase activity and glutathione content in rats

Abstract

The present study evaluates the effect of oral administration of papaverine at differential dosing regimens (100 mg/kg bw and 200 mg/kg bw) on the hepatic and pulmonary glutathione S-transferase (GST) activity and glutathione content (GSH) in male Wistar rats. Papaverine treatment caused a pronounced increase in GST activity and GSH content at the higher dosing level in the rat liver and lung. We conclude that papaverine, can possibly act as a chemopreventive agent against chemical carcinogenesis.

Papaverine attenuates the progression of alpha naphthylisothiocyanate induce cholestasis in rats

“…The animals were divided into three groups, and each group had ten rats: (I) control group rats received 1 mL/kg of corn oil orally via oral gavage 48 h before sacrifice; (II) ANIT (Cholestasis) group: oral administration of 100 mg/kg ( Uchida et al, 2002 ) ANIT via gavage 48 h before sacrifice, 100 mg of ANIT dissolved in 1 ml of corn oil. (III) cholestasis + Papaverine group: Papaverine was administered (200 mg/kg) ( Aneja et al, 2004 ) via oral gavage for seven consecutive days at day five ANIT (100 mg/kg) given orally, papaverine dissolved in water at a concentration of 25 mg/ml. Animals were euthanized 48 h after inducing cholestasis, and liver tissue and blood samples were taken after animal sacrifice.…”

Possible Protective Effect of Low Dose of Papaverine on ANIT Induce Cholestasis in Rat

“…(3) Group III rats were administered 100mg/kg (18) papaverine (PPV) orally for 7 consecutive days and at day 5, ANIT 100mg/kg was orally administered to rats 48 hours before sacrifice. At the end of the experiment, the animals in each group were euthanized by diethyl ether and sacrificed.…”