Papaver bracteatum Lindi.: Quantitative Extraction and Determination of Thebaine

Vincent, Phillip G.; Gentner, W. A.; Küppers, F.J.E.M.; Salemink, C. A.

doi:10.1002/jps.2600680127

Cited by 8 publications

(1 citation statement)

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“…(Papaveraceae) is a sturdy perennial herb indigenous in Iran and many other regions in the world [7]. Chemical studies have demonstrated the presence of rhoeadic acid [8,9], thebaine [10,11], papaveric acid [12], and anthocyanins [13] as the major compounds of the extract of Papaveraceae family. Phenolic compounds and alkaloids of the P. bracteatum Lindl.…”

Section: Introductionmentioning

confidence: 99%

The effect of intra‐peritoneal administration of Papaver bracteatum Lindl. extract on development of NMRI mice oocytes treated with Doxorubicin

Jafarian

Eimani

Azarnia

et al. 2012

Reprod Medicine & Biology

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Purpose The effect of water-alcohol Papaver bracteatum Lindl. extract on development of mice oocytes treated with Doxorubicin (dox) was examined in this study. Methods The mice were classified into four groups. Control group, mice injected intraperitoneally (IP) with saline. Extract group alone, mice treated with 200 mg/kg of body weight (bw), IP, twelve consecutive days. Dox group alone, mice were given dox, IP, 10 mg/kg bw. Experimental group treated with extract and dox together. Effect of the extract on the development of mice oocytes treated with dox were evaluated through assisted reproductive technology techniques (ARTs). Results Developmental rate and blastocyst formation was improved by using the extract. A significant increase in in vitro developmental competence in comparison with dox group (P \ 0.05) was observed. Conclusions The results of this study indicated that P. bracteatum Lindl. extract could prevent dox toxicity of dox affecting both follicle or oocytes, and therefore it can result in improved embryo development which was observed in mice treated with dox plus P. bracteatum Lindl. compared to mice treated with dox alone.

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