Objectives
As many as half of the patients recommended for osteoporosis pharmacotherapy do not take their medications. We examined patient characteristics associated with non-adherence to recommended pharmacotherapy, as well as their reasons for non-adherence in order to identify intervention targets.
Methods
Data come from the Patient Activation after DXA Result Notification (PAADRN) study, a randomized controlled trial of 7,749 patients 50 years old or older presenting for DXA at three health centers in the United States. We focused on the 790 patients who reported receiving a recommendation for new pharmacotherapy at baseline. Using Pearson Chi-squared tests for categorical variables, two sample t-tests for continuous variables, and multivariable multinomial logistic regression, we compared those who reported starting the recommended medication (adherers) to temporary non-adherers and non-adherers on demographics, health habits, DXA impression, FRAX risk, and osteoporosis knowledge, and examined their stated reasons for non-adherence.
Results
Mean age was 66.8 (SD = 8.9), 87.2% were women, and 84.2% were white. One-fourth (24.8%) reported that they did not start their recommended pharmacotherapy. In the unadjusted analyses, the only factor significantly associated with non-adherence was osteoporosis knowledge, with those having better knowledge less likely to take their medications (p < 0.05). The most common reasons for non-adherence were fear of side effects (53.3%), a dislike of taking medicine (25.3%), and the belief that the medicine would not help their condition (16.7%).
Conclusion
One in four patients recommended for osteoporosis pharmacotherapy declined treatment because they feared potential side effects, don’t like taking medicine, or felt that the medication would not help their condition. Improved patient counseling regarding the potential side effects of osteoporosis treatment and the risk-benefit ratio for these medications may increase adherence.