Pantomiming tool use with an imaginary tool in hand as compared to demonstration with tool in hand specifically modulates the left middle and superior temporal gyri

Lausberg, Hedda; Kazzer, Philipp; Heekeren, Hauke R.; Wartenburger, Isabell

doi:10.1016/j.cortex.2015.05.021

Cited by 20 publications

(11 citation statements)

References 85 publications

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“…Indeed, lesions or degeneration of fronto-parietal connecting fiber tracts were found to impair praxis abilities (Kertesz and Ferro 1984; Zadikoff and Lang 2005; Borroni et al 2008; Manuel et al 2013). Moreover, left temporal regions were also found to be involved in praxis as reported from functional imaging studies (Choi et al 2001; Johnson-Frey et al 2005; Vingerhoets et al 2011; Mäki-Marttunen et al 2014; Lausberg et al 2015; Vry et al 2015) or lesion studies (Buxbaum et al 2014; Watson and Buxbaum 2015). Additional, subcortical lesions can lead to apraxia as reported for the thalamus (Pramstaller and Marsden 1996; Buxbaum et al 2014) and the basal ganglia (Pramstaller and Marsden 1996; Hanna-Pladdy et al 2001; Huey et al 2009).…”

Section: Introductionmentioning

confidence: 66%

Early dysfunctions of fronto-parietal praxis networks in Parkinson’s disease

Matt

Foki

Fischmeister

et al. 2016

Brain Imaging and Behavior

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In Parkinson’s disease (PD) the prevalence of apraxia increases with disease severity implying that patients in early stages may already have subclinical deficits. The aim of this exploratory fMRI study was to investigate if subclinical aberrations of the praxis network are already present in patients with early PD. In previous functional imaging literature only data on basal motor functions in PD exists. Thirteen patients with mild parkinsonian symptoms and without clinically diagnosed apraxia and 14 healthy controls entered this study. During fMRI participants performed a pantomime task in which they imitated the use of visually presented objects. Patients were measured ON and OFF dopaminergic therapy to evaluate a potential medication effect on praxis abilities and related brain functions. Although none of the patients was apraxic according to De Renzi ideomotor scores (range 62–72), patients OFF showed significantly lower praxis scores than controls. Patients exhibited significant hyperactivation in left fronto-parietal core areas of the praxis network. Frontal activations were clearly dominant in patients and were correlated with lower individual praxis scores. We conclude that early PD patients already show characteristic signs of praxis network dysfunctions and rely on specific hyperactivations to avoid clinically evident apraxic symptoms. Subclinical apraxic deficits were shown to correlate with an activation shift from left parietal to left frontal areas implying a prospective individual imaging marker for incipient apraxia.

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Section: Introductionmentioning

confidence: 66%

Early dysfunctions of fronto-parietal praxis networks in Parkinson’s disease

Matt

Foki

Fischmeister

et al. 2016

Brain Imaging and Behavior

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“…The findings in the present study are not only able to reconcile several discrepancies within the lesion-behaviour mapping literature in apraxia, but also discrepancies between lesion-behaviour mapping studies and fMRI studies. As in lesion studies, fMRI experiments that investigated pantomime also found several different left hemisphere regions to be involved (for reviews see Johnson-Frey, 2004;Lewis, 2006;Niessen et al, 2014; see also Lausberg et al, 2015;Vry et al, 2015;Martin et al, 2016;Chen et al, 2017). Parietal regions, including the intraparietal sulcus, inferior parietal lobe, and/or superior parietal lobe, were found activated in nearly all studies during pantomime (Niessen et al, 2014).…”

Section: Discussionmentioning

confidence: 89%

“…Parietal regions, including the intraparietal sulcus, inferior parietal lobe, and/or superior parietal lobe, were found activated in nearly all studies during pantomime (Niessen et al, 2014). Beyond, activation in middle and inferior frontal gyrus, inferior, middle and superior temporal lobe, inferior occipital gyrus, precentral gyrus, and insula were reported in some of these studies (Lewis, 2006;Niessen et al, 2014;Lausberg et al, 2015;Martin et al 2016). The present finding suggesting a complex network to underlie higher-order motor control thus is in line with these observations derived from healthy subjects.…”

Section: Discussionmentioning

confidence: 92%

The network underlying human higher-order motor control: Insights from machine learning-based lesion-behaviour mapping in apraxia

Sperber

Wiesen

Goldenberg

et al. 2019

Preprint

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Neurological patients with apraxia of pantomime provide us with a unique opportunity to study the neural correlates of higher-order motor function. Previous studies using lesion-behaviour mapping methods led to inconsistent anatomical results, reporting various lesion locations to induce this symptom. We hypothesised that the inconsistencies might arise from limitations of mass-univariate lesionbehaviour mapping approaches if our ability to pantomime the use of objects is organised in a brain network. Thus, we investigated apraxia of pantomime by using multivariate lesion behaviour mapping based both on support vector regression and sparse canonical correlations in a sample of 130 left-hemisphere stroke patients. Both multivariate methods identified multiple areas to underlie high-order motor control, including inferior parietal lobule, precentral gyrus, posterior parts of middle temporal cortex, and insula. Further, long association fibres were affected, such as the superior longitudinal fascicle, inferior occipito-frontal fascicle, uncinated fascicle, and superior occipito-frontal fascicle. The findings thus not only underline the benefits of multivariate lesion-behaviour mapping in brain networks, but they also uncovered that higher-order motor control indeed is based on a common anatomical network.

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“…In the light of these findings, several theories postulated a brain network to underlie apraxia, and further studies, e.g. using electroencephalography 16 , fMRI 17,18 , and fibre tracking in healthy subjects 19 , support this assumption.…”

Section: Introductionmentioning

confidence: 78%

Mapping the human praxis network: an investigation of white matter disconnection in apraxia

Rosenzopf

Wiesen

Basilakos

et al. 2020

Preprint

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Stroke to the left hemisphere of the brain can cause limb apraxia, a disorder characterised by deficits of higher order motor skills such as the failure to accurately produce meaningful gestures. This disorder provides unique insights into the anatomy of the human praxis system.The present study aimed to identify the structural brain network, that when damaged by stroke, causes limb apraxia. We assessed the ability to perform meaningful gestures with the hand in 101 patients with chronic left hemisphere stroke. Structural damage to white matter fibres was assessed by diffusion tensor imaging. A support vector regression model predicting apraxia based on individual topographies of tract-based fractional anisotropy was utilised to obtain multivariate topographical inference. We found pathological white matter alterations in a densely connected fronto-temporo-parietal network of short and long association fibres to predict limb apraxia deficits. Major disconnection affected temporo-parietal and temporotemporal connections. Grey matter areas with a high number of disconnections included inferior parietal lobe, middle and superior temporal gyrus, inferior and middle frontal lobe, precentral gyrus, putamen, and caudate nucleus. These results demonstrate the relevance of frontal and inferior parietal regions in praxis, but they also highlight the temporal lobe and its connections to be an important contributor to the human praxis network.

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Pantomiming tool use with an imaginary tool in hand as compared to demonstration with tool in hand specifically modulates the left middle and superior temporal gyri

Cited by 20 publications

References 85 publications

Early dysfunctions of fronto-parietal praxis networks in Parkinson’s disease

Early dysfunctions of fronto-parietal praxis networks in Parkinson’s disease

The network underlying human higher-order motor control: Insights from machine learning-based lesion-behaviour mapping in apraxia

Mapping the human praxis network: an investigation of white matter disconnection in apraxia

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