Pantoea agglomerans: An Elusive Contributor to Chronic Obstructive Pulmonary Disease Exacerbation

Shrestha, Binav; Nabin, K C; Bastola, Chhabilal; Jahir, Tahmina; Risal, Ruby; Thapa, Shivani; Enriquez, Danilo; Schmidt, Frances

doi:10.7759/cureus.18562

Cited by 7 publications

(5 citation statements)

References 22 publications

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“…It is underlined that inhaled Pseudomonas. agglomerans endotoxins could determine the activation of alveolar macrophages and secretion of mediators such as interleukin-1, tumor necrosis factor (TNF), and prostaglandins, that lead to the accumulation of platelets in pulmonary capillaries triggering acute and chronic inflammation and later to bronchoconstriction, reduced forced expiratory volume in the first second, reduced diffusing capacity of the lung for carbon monoxide, and increased airway reactivity, which leads to significant respiratory symptoms ( Shrestha B et al., 2021 ).…”

Section: Human Microbiota/respiratory Tract Microbiotamentioning

confidence: 99%

Lung microbiome: new insights into bronchiectasis’ outcome

Azoicai,

Lupu,

Alexoae

et al. 2024

Front. Cell. Infect. Microbiol.

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The present treatments for bronchiectasis, which is defined by pathological dilatation of the airways, are confined to symptom relief and minimizing exacerbations. The condition is becoming more common worldwide. Since the disease’s pathophysiology is not entirely well understood, developing novel treatments is critically important. The interplay of chronic infection, inflammation, and compromised mucociliary clearance, which results in structural alterations and the emergence of new infection, is most likely responsible for the progression of bronchiectasis. Other than treating bronchiectasis caused by cystic fibrosis, there are no approved treatments. Understanding the involvement of the microbiome in this disease is crucial, the microbiome is defined as the collective genetic material of all bacteria in an environment. In clinical practice, bacteria in the lungs have been studied using cultures; however, in recent years, researchers use next-generation sequencing methods, such as 16S rRNA sequencing. Although the microbiome in bronchiectasis has not been entirely investigated, what is known about it suggests that Haemophilus, Pseudomonas and Streptococcus dominate the lung bacterial ecosystems, they present significant intraindividual stability and interindividual heterogeneity. Pseudomonas and Haemophilus-dominated microbiomes have been linked to more severe diseases and frequent exacerbations, however additional research is required to fully comprehend the role of microbiome in the evolution of bronchiectasis. This review discusses recent findings on the lung microbiota and its association with bronchiectasis.

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Section: Human Microbiota/respiratory Tract Microbiotamentioning

confidence: 99%

Lung microbiome: new insights into bronchiectasis’ outcome

Azoicai,

Lupu,

Alexoae

et al. 2024

Front. Cell. Infect. Microbiol.

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“…Among the pathological effects, acute and chronic inflammation have been reported, resulting in damage to the endothelial cells and the leakage of cells and fluids into the pulmonary interstitium. These changes cause bronchoconstriction, fever, irritation of the airways, and chest tightness [ 29 , 90 ]. Although other microbial and plant constituents are also considered to be potential causative agents of byssinosis (i.e., reactive airway disease), the endotoxin produced by P. agglomerans strains and other Gram-negative bacteria in cotton dust is still considered to be a major cause of the disease.…”

Section: Pathogenic Potential Of P Agglomerans And...mentioning

confidence: 99%

Opposite Sides of Pantoea agglomerans and Its Associated Commercial Outlook

et al. 2022

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Multifaceted microorganisms such as the bacterium Pantoea colonize a wide range of habitats and can exhibit both beneficial and harmful behaviors, which provide new insights into microbial ecology. In the agricultural context, several strains of Pantoea spp. can promote plant growth through direct or indirect mechanisms. Members of this genus contribute to plant growth mainly by increasing the supply of nitrogen, solubilizing ammonia and inorganic phosphate, and producing phytohormones (e.g., auxins). Several other studies have shown the potential of strains of Pantoea spp. to induce systemic resistance and protection against pests and pathogenic microorganisms in cultivated plants. Strains of the species Pantoea agglomerans deserve attention as a pest and phytopathogen control agent. Several of them also possess a biotechnological potential for therapeutic purposes (e.g., immunomodulators) and are implicated in human infections. Thus, the differentiation between the harmful and beneficial strains of P. agglomerans is mandatory to apply this bacterium safely as a biofertilizer or biocontroller. This review specifically evaluates the potential of the strain-associated features of P. agglomerans for bioprospecting and agricultural applications through its biological versatility as well as clarifying its potential animal and human health risks from a genomic point of view.

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“…and circumstances of exposure. Out of Gram-negative bacteria associated with wood dust a special attention should be paid in this respect to the ubiquitous species Pantoea agglomerans , recently indicated as an agent causing exacerbations of the chronic obstructive pulmonary disease (COPD) (Shrestha et al 2021 ). Earlier, it has been demonstrated experimentally that this species produces as well a potent endotoxin (Dutkiewicz 1976 ; Rylander and Lundholm 1978 ).…”

Section: Endotoxin Effectsmentioning

confidence: 99%

Timber-colonizing gram-negative bacteria as potential causative agents of respiratory diseases in woodworkers

Wójcik-Fatla

Maćkiewicz

Sawczyn-Domańska

et al. 2022

Int Arch Occup Environ Health

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Occurrence Gram-negative bacteria occur commonly in the inner tissues of stored coniferous and deciduous timber, showing a marked variation in numbers. The greatest maximal numbers are found in the sapwood of coniferous timber. The common constituents of the Gram-negative biota are potentially pathogenic species of Enterobacteriaceae family of the genera Rahnella, Pantoea, Enterobacter, and Klebsiella. The air of wood-processing facilities is polluted with the wood-borne Gram-negative bacteria and produced by them endotoxin, as demonstrated worldwide by numerous studies. Effects There are three potential pathways of the pathogenic impact of wood-borne Gram-negative bacteria on exposed woodworkers: allergic, immunotoxic, and infectious. Allergic impact has been underestimated for a long time with relation to Gram-negative bacteria. Hopefully, the recent demonstration of the first documented case of hypersensitivity pneumonitis (HP) in woodworkers caused by Pantoea agglomerans which developed in extremely large quantities in birch sapwood, would speed up finding of new wood-related cases of HP caused by Gram-negative bacteria. The second pathway is associated with endotoxin, exerting strong immunotoxic (excessively immunostimulative) action. It has been demonstrated that endotoxin is released into wood dust in the form of nano-sized microvesicles, by peeling off the outer membrane of bacteria. Endotoxin microvesicles are easily inhaled by humans together with dust because of small dimensions and aerodynamic shape. Afterwards, they cause a nonspecific activation of lung macrophages, which release numerous inflammatory mediators causing an inflammatory lung reaction, chest tightness, fever, gas exchange disorders, and bronchospasm, without radiographic changes. The resulting disease is known as “Organic Dust Toxic Syndrome” or “toxic pneumonitis.” The potential third pathway of pathogenic impact is infection. The suspected species is Klebsiella pneumoniae that may occur commonly in wood dust; however, until now this pathway has not been confirmed. Conclusion Summarizing, Gram-negative bacteria-inhabiting timber should be considered, besides filamentous fungi and actinobacteria, as important risk factors of occupational disease in woodworkers that could be either HP with allergenic background or toxic pneumonitis elicited by endotoxin.

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Pantoea agglomerans: An Elusive Contributor to Chronic Obstructive Pulmonary Disease Exacerbation

Cited by 7 publications

References 22 publications

Lung microbiome: new insights into bronchiectasis’ outcome

Lung microbiome: new insights into bronchiectasis’ outcome

Opposite Sides of Pantoea agglomerans and Its Associated Commercial Outlook

Timber-colonizing gram-negative bacteria as potential causative agents of respiratory diseases in woodworkers

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