Panresistant Superbugs: Are We at the Edge of a ‘Microbial Holocaust’

Khan, I. D.; Rajmohan, KS; Jindal, A.K.; Gupta, Rajeev; Khan, Saira; Shukla, Maulik; Singh, Shalini; Mustafa, Sh.; Tejus, A; Narayanan, Sandhya

doi:10.11603/ijmmr.2413-6077.2017.2.8012

Cited by 3 publications

(2 citation statements)

References 15 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…A patient presented with fever of unknown origin (FUO) with evidence of hemophagocytic lymphohistiocytosis (HLH) in the bone marrow. Emerging fungal infections can pose a serious threat in contemporary health care due to host variations, clinical presentation and emerging resistance [2][3][4][5][6][7][8]. There are diagnostic stringencies in resource limited facilities [9,10].…”

Section: Introductionmentioning

confidence: 99%

Disseminated Histoplasmosis Leading to Haemophagocytic Lymphohistiocytosis in an Immunocompetent Patient

Khan

Brijwal

Joshi

et al. 2020

IJMMR

Self Cite

View full text Add to dashboard Cite

Background: Emerging fungal infections can pose a serious threat in contemporary healthcare due to host variations, clinical presentation and emerging resistance. Histoplasma capsulatum is a thermally dimorphic fungus, which acts as a Trojan horse by residing inside macrophages. Histoplasmosis is an emerging infection and its association with hemophagocytic lymphohistiocytosis (HLH) in immunocompetent patients has been scantily reported in the literature. Objective. The aim of the study was to explore disseminated histoplasmosis with the help of case report. Methods: A case report of histoid leprosy is presented. Results: A male patient of 47 yearsof age, under treatment for chronic obstructive pulmonary disease for five years and diabetes mellitus Type-II for two years, presented with fever of unknown origin (FUO) with evidence of HLH in the bone marrow. Core biopsy of the liver and spleen showed a dense tissue infiltrate with vacuolated histiocytes containing histoplasma capsulatum, eosinophils, some lymphocytes and plasma cells. Conclusion: Histoid leprosy is a discrete infrequent form of multibacillary leprosy with distinctive clinical, bacteriological and histomorphological features. Histopathologic examination with modified fite stain remains the mainstay of diagnosis.

show abstract

Section: Introductionmentioning

confidence: 99%

Disseminated Histoplasmosis Leading to Haemophagocytic Lymphohistiocytosis in an Immunocompetent Patient

Khan

Brijwal

Joshi

et al. 2020

IJMMR

Self Cite

View full text Add to dashboard Cite

show abstract

“…Sepsis ensues prolonged hospital stay and aggressive exposure to a cocktail of antimicrobials thereby increasing healthcare costs and furthering antimicrobial resistance. [1][2][3] Septic shock and multiorgan dysfunction is the terminal stage in critically ill patients leading to perfusion abnormalities, lactic acidosis, oliguria and altered mental status creating a rapid downhill course and mortality. Sepsis ensues through stages of exaggerated immune response including systemic inflammatory response syndrome, in the backdrop of infectious stimuli.…”

Section: Introductionmentioning

confidence: 99%

Polymicrobial Septic Shock with Multiorgan Dysfunction in an Otherwise Healthy Immunocompetent Patient

Hashmi¹,

Nair²,

Gupta³

et al. 2014

Journal of Medical Academics

View full text Add to dashboard Cite

Background: Sepsis is a significant cause of morbidity and mortality worldwide despite advanced critical life-support. Septic shock and multiorgan dysfunction is the terminal stage in critically ill patients leading to perfusion abnormalities, lactic acidosis, oliguria and altered mental status creating a rapid downhill course and mortality. Sepsis ensues through stages of exaggerated immune response including systemic inflammatory response syndrome, in the backdrop of infectious stimuli.Case report: Polymicrobial septic shock with multiorgan dysfunction leads to demise in an otherwise healthy immunocompetent patient. Microbiological profile revealed Escherichia coli urinary tract infection (UTI), Staphylococcus sciuri bacteremia, Acinetobacter baumanii ventilator-associated pneumonia, and central line catheter tip Pseudomonas aeruginosa, thereby pointing towards polymicrobial sepsis. Neutropenia of 290/ dL along with serum procalcitonin 5 ng/mL was detected. An autopsy revealed anasarca, bilateral lung abscesses, Hepatosplenomegaly, intracerebral hemorrhage, consolidated lungs, myocardial hypertrophy, and acute tubular necrosis were observed. Bacterial colonies from lungs, liver and cerebrospinal fluid grew Pseudomonas aeruginosa. Conclusion:Polymicrobial sepsis can rapidly deteriorate a patient and mandate aggressive fluid, inotrope, ventilation, and antimicrobial therapy, notwithstanding challenges in diagnosis, prognosis and optimal management.

show abstract

Primary Laryngeal Aspergillosis in an Immunocompetent Patient

Rajmohan

Khan

Kapoor³

et al. 2020

IJMMR

Self Cite

View full text Add to dashboard Cite

Background. Aspergillus is an inherently ubiquitous, weakly pathogenic fungus causing opportunistic infections. It is very rarely localized in the larynx, although laryngeal Aspergillosis may develop in the immunocompromised patients including those with leukaemia and severe aplastic anaemia. Objective. The aim of the research was to explore the primary laryngeal Aspergillosis in an immunocompetent patient thru a case report. Methods. A case report of primary laryngeal Aspergillosis in an immunocompetent patient is presented. Results. A male patient of 40 years old, presenting with chronic worsening hoarseness, was found to have a smooth, white spheroid submucosal growth on left vocal cord with preserved bilateral cord movements on videostroboscopy. Histopathological examination of vocal cord growth revealed squamous epithelium containing septate hyphae with acute angle dichotomous branching pattern consistent with Aspergillus. Voice improved after a four-week course of oral itraconazole 200 mg/day. Post therapy follow up of 24 months was unremarkable. Conclusions. Primary laryngeal Aspergillosis develops in the immunocompetent patients. Iatrogenic, vocal abuse, occupation and lifestyle factors may be contributory. Optimal diagnosis and management mandates a high index of suspicion.

show abstract

Panresistant Superbugs: Are We at the Edge of a ‘Microbial Holocaust’

Abstract: Contemporary healthcare has progressed towards world health security through advancements in medication-

Cited by 3 publications

References 15 publications

Disseminated Histoplasmosis Leading to Haemophagocytic Lymphohistiocytosis in an Immunocompetent Patient

Disseminated Histoplasmosis Leading to Haemophagocytic Lymphohistiocytosis in an Immunocompetent Patient

Polymicrobial Septic Shock with Multiorgan Dysfunction in an Otherwise Healthy Immunocompetent Patient

Primary Laryngeal Aspergillosis in an Immunocompetent Patient

Contact Info

Product

Resources

About