Panoramic on Epigenetics in Coronary Artery Disease and the Approach of Personalized Medicine

Bergonzini, Marcello; Loreni, Francesco; Lio, Antonio; Russo, Marco; Saitto, Guglielmo; Cammardella, Antonio; Irace, Francesco; Tramontin, Corrado; Chello, Massimo; Lusini, Mario; Nenna, Antonio; Ferrisi, Chiara; Ranocchi, Federico; Musumeci, Francesco

doi:10.3390/biomedicines11102864

Cited by 3 publications

(1 citation statement)

References 168 publications

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“…Recognizing the synergistic effects of hypertension, epigenetic modifications, and T2DM on CAD development is crucial for effective risk assessment and management strategies ( 143 ). Clinicians should consider these factors when evaluating cardiovascular risk in patients with T2DM.…”

Section: Discussionmentioning

confidence: 99%

Epigenetics of hypertension as a risk factor for the development of coronary artery disease in type 2 diabetes mellitus

Karabaeva,

Vochshenkova,

Mussin

et al. 2024

Front. Endocrinol.

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Hypertension, a multifaceted cardiovascular disorder influenced by genetic, epigenetic, and environmental factors, poses a significant risk for the development of coronary artery disease (CAD) in individuals with type 2 diabetes mellitus (T2DM). Epigenetic alterations, particularly in histone modifications, DNA methylation, and microRNAs, play a pivotal role in unraveling the complex molecular underpinnings of blood pressure regulation. This review emphasizes the crucial interplay between epigenetic attributes and hypertension, shedding light on the prominence of DNA methylation, both globally and at the gene-specific level, in essential hypertension. Additionally, histone modifications, including acetylation and methylation, emerge as essential epigenetic markers linked to hypertension. Furthermore, microRNAs exert regulatory influence on blood pressure homeostasis, targeting key genes within the aldosterone and renin-angiotensin pathways. Understanding the intricate crosstalk between genetics and epigenetics in hypertension is particularly pertinent in the context of its interaction with T2DM, where hypertension serves as a notable risk factor for the development of CAD. These findings not only contribute to the comprehensive elucidation of essential hypertension but also offer promising avenues for innovative strategies in the prevention and treatment of cardiovascular complications, especially in the context of T2DM.

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Section: Discussionmentioning

confidence: 99%

Epigenetics of hypertension as a risk factor for the development of coronary artery disease in type 2 diabetes mellitus

Karabaeva,

Vochshenkova,

Mussin

et al. 2024

Front. Endocrinol.

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Epigenetic regulation in epilepsy: A novel mechanism and therapeutic strategy for epilepsy

Chen,

Huang,

et al. 2024

Neurochemistry International

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There Is No Direct Causal Relationship Between Coronary Artery Disease and Alzheimer Disease: A Bidirectional Mendelian Randomization Study

Zhong,

Tan,

Liu

et al. 2024

JAHA

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Background The association between poor cardiovascular health and cognitive decline as well as dementia progression has been inconsistent across studies. This study used Mendelian randomization (MR) to investigate the causal relationship between Alzheimer disease (AD), circulating levels of total‐tau, and coronary artery disease (CAD). Methods and Results This study used MR to investigate the causal relationship between AD or circulating levels of total‐tau and CAD, including ischemic heart disease, myocardial infarction, coronary heart disease, coronary atherosclerosis, and heart failure. The primary analysis used the inverse‐variance weighted method, with pleiotropy and heterogeneity assessed using MR‐Egger regression and the Q statistic. The overall results of the MR analysis indicated that AD did not exhibit a causal effect on heart failure (odds ratio [OR], 0.969 [95% CI, 0.921–1.018]; P =0.209), myocardial infarction (OR, 0.972 [95% CI, 0.915–1.033]; P =0.359), ischemic heart disease (OR, 1.013 [95% CI, 0.949–1.082]; P =0.700), coronary heart disease (OR, 1.005 [95% CI, 0.937–1.078]; P =0.881), or coronary atherosclerosis (OR, 0.987 [95% CI, 0.926–1.052]; P =0.690). No significant causal effect of CAD was observed on AD in the reverse MR analysis. Additionally, our findings revealed that CAD did not influence circulating levels of total‐tau, nor did circulating levels of total‐tau increase the risk of CAD. Sensitivity analysis and assessment of horizontal pleiotropy suggested that these factors did not distort the causal estimates. Conclusions The findings of this study indicate the absence of a direct causal relationship between AD and CAD from a genetic perspective. Therefore, managing the 2 diseases should be more independent and targeted. Concurrently, investigating the mechanism underlying their comorbidity may not yield meaningful insights for advancing treatment strategies.

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Panoramic on Epigenetics in Coronary Artery Disease and the Approach of Personalized Medicine

Cited by 3 publications

References 168 publications

Epigenetics of hypertension as a risk factor for the development of coronary artery disease in type 2 diabetes mellitus

Epigenetics of hypertension as a risk factor for the development of coronary artery disease in type 2 diabetes mellitus

Epigenetic regulation in epilepsy: A novel mechanism and therapeutic strategy for epilepsy

There Is No Direct Causal Relationship Between Coronary Artery Disease and Alzheimer Disease: A Bidirectional Mendelian Randomization Study

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