PANoptosis signaling enables broad immune response in psoriasis: From pathogenesis to new therapeutic strategies

Hu, Xi-min; Zheng, Shengyuan; Zhang, Qi; Wan, Xinxing; Li, Ji; Mao, Rui; Yang, Ronghua; Xiong, Kun

doi:10.1016/j.csbj.2023.11.049

Cited by 7 publications

(5 citation statements)

References 70 publications

(81 reference statements)

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“…Psoriasis‐like mice treated with DSF had reduced scores for erythema, induration and desquamation of plaques. Moreover, the histological analysis showed that DSF decreased the thickness of the skin‐fold and spleen index in psoriatic mice 45 . In summary, the inhibition of GSDMD/GSDME‐mediated pyroptosis by the topical application of disulfiram or the knockout of GSDME can effectively restore the development of psoriatic dermatitis in a mouse model, suggesting that the targeted pyroptosis may be considered as a therapeutic strategy.…”

Section: Introductionmentioning

confidence: 90%

“…Moreover, the histological analysis showed that DSF decreased the thickness of the skin-fold and spleen index in psoriatic mice. 45 In summary, the inhibition of GSDMD/GSDME-mediated pyroptosis by the topical application of disulfiram or the knockout of GSDME can effectively restore the development of psoriatic dermatitis in a mouse model, suggesting that the targeted pyroptosis may be considered as a therapeutic strategy. However, which components of the psoriatic immune microenvironment cause the initiation of keratinocytes pyroptosis need to be determined in further investigation.…”

Section: In Gsdmdmentioning

confidence: 97%

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Pyroptosis and its role in autoimmune skin disease

Yao,

Wang,

et al. 2024

Experimental Dermatology

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Autoimmune skin disease is a kind of heterogeneous disease with complicated pathogenesis. Many factors such as genetic, infectious, environmental and even psychological factors may interact together to trigger a synergistic effect for the development of abnormal innate and adaptive immune responses. Although the exact mechanisms remain unclear, recent evidence suggests that pyroptosis plays a pivotal role in the development of autoimmune skin disease. The feature of pyroptosis is the first formation of pores in cellular membranes, then cell rupture and the release of intracellular substances and pro‐inflammatory cytokines, such as interleukin‐1 beta (IL‐1β) and IL‐18. This hyperactive inflammatory programmed cell death damages the homeostasis of the immune system and advances autoimmunity. This review briefly summarises the molecular regulatory mechanisms of pyrin domain‐containing protein 3 (NLRP3) inflammasome and gasdermin family, as well as the molecular mechanisms of pyroptosis, highlights the latest progress of pyroptosis in autoimmune skin disease, including systemic lupus erythematosus, psoriasis, atopic dermatitis and systemic scleroderma and attempts to identify its potential advantages as a therapeutic target or prognostic biomarker for these diseases.

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Section: Introductionmentioning

confidence: 90%

Section: In Gsdmdmentioning

confidence: 97%

Pyroptosis and its role in autoimmune skin disease

Yao,

Wang,

et al. 2024

Experimental Dermatology

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“…Various websites were searched for the targets of action of the active ingredients in acacetin, and potential targets of liver fibrosis were screened [ 29 ]. Subsequently, a visualized acacetin-target network was established using Cytoscape v3.9.1.…”

Section: Methodsmentioning

confidence: 99%

Mechanism of acacetin regulating hepatic stellate cell apoptosis based on network pharmacology and experimental verification

Hu,

Shen,

Liu

et al. 2024

Heliyon

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“…Anti-β-actin monoclonal antibody (66009, Proteintech, China) at a 1:10000 dilution was used as a loading control. 20 The signal was developed by an enhanced chemiluminescence substrate (U10010A, Keyoubo, China) and captured by a chemiluminescent imaging system (4100, Tanon, China). Scanning and analysis were performed using Imaging J software and GraphPad software.…”

Section: Western Blotmentioning

confidence: 99%

Tat-CIRP Peptide Facilitates Frozen Wound Healing by Ameliorating Inflammation and Promoting Angiogenesis

Li,

Ding,

et al. 2024

JIR

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Background: Frostbite is a chemia resulting from cold-induced skin damage. The process of frostbite is often accompanied by inflammation, and the therapeutic strategies focusing on anti-inflammation are the main direction to data. Tat-CIRP is a 15 amino acid peptide containing HIV protein and cold-inducible RNA-binding protein (CIRP), which is believed to compete with endogenous CIRP for myeloid differentiation 2 (MD2) binding. This study aims to investigate the efficacy of Tat-CIRP in the treatment of frostbite. Methods: A mouse model of frostbite was established, and on the first day after frostbite occurrence, Tat-CIRP peptide was administered intravenously via the tail with a dosage interval of one day for a total of three doses. Frozen mouse skin sections were subjected to histological analysis, including hematoxylin-eosin (HE) staining, Masson staining, and immunohistochemical examination. Western blotting was performed to detect the expression level of Ki-67 in mouse skin tissue. Results: One day after frostbite, mice exhibited skin swelling and a solid appearance. From day 1 to 5 after frostbite, MD2 expression was significantly upregulated, while CIRP expression was downregulated. Compared to the frostbite group, mice treated with Tat-CIRP showed accelerated frostbite recovery, reduced levels of inflammatory factors and MD2. Furthermore, the expression of cell proliferation-associated protein Ki-67 and angiogenesis-related protein CD31 was upregulated. Conclusion: Tat-CIRP promotes frozen wound healing via inhibiting inflammation and promoting angiogenesis in frostbitten mice.

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PANoptosis signaling enables broad immune response in psoriasis: From pathogenesis to new therapeutic strategies

Cited by 7 publications

References 70 publications

Pyroptosis and its role in autoimmune skin disease

Pyroptosis and its role in autoimmune skin disease

Mechanism of acacetin regulating hepatic stellate cell apoptosis based on network pharmacology and experimental verification

Tat-CIRP Peptide Facilitates Frozen Wound Healing by Ameliorating Inflammation and Promoting Angiogenesis

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