Panniculitis in Connective Tissue Disease

Winkelmann, R. K.

doi:10.1001/archderm.1983.01650280064019

Cited by 154 publications

(81 citation statements)

References 57 publications

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“…Pathological changes are characterized by hyaline fat necrosis, lymphocytic infiltration with lymphoid nodules, periseptal or lobular panniculitis, calcifications and lymphocytic vasculitis [2,3,7]. Immunoglobulin and complement at the basement membrane and around blood vesels can be detected with immunofluorescence [5,6].…”

Section: Discussionmentioning

confidence: 99%

Lupus panniculitis involving the breast

et al. 2005

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Lupus panniculitis is an unusual immunological disease that characteristically affects the subcutaneous fat and occurs in 2% of patients with systemic lupus erythematosus. We report a case of lupus panniculitis involving the breast, which represents a very uncommon location. Mammographically, it presented as a suspicious irregular mass involving the subcutaneous fat pad with skin thickening. High echogenicity constituted the most relevant sonographic finding. To the best of our knowledge, the magnetic resonance (MR) features have not been previously described. High signal intensity was found on both T1- and T2-weighted precontrast MR images. A dynamic contrast-enhanced study revealed a suspicious focal mass with irregular margins and rim enhancement, with a type 3 time-signal intensity curve. Differential diagnosis with carcinoma and fat necrosis and the value of core biopsy are discussed.

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Section: Discussionmentioning

confidence: 99%

Lupus panniculitis involving the breast

et al. 2005

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“…anti-DNA and/or anti-ENA antibodies are present in 75% of the cases [1 ]: a positive lupus band test can also be present. In connective tissue panni culitis described by Peters and Winkelmann [5], it is possible to observe transient ANAs, anti-ENA antibodies or complement level ab normalities [17][18][19]. This may precede the onset of autoimmune disease at an adult age ] 17].…”

Section: Discussionmentioning

confidence: 99%

Localized Lipoatrophia with Persistent Circulating Autoantibodies and Partial Immunoglobulin A Deficiency in a Child

Tremeau-Martinage

Bayle-Lebey²,

Grouteau³

et al. 1996

Dermatology

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A 7-year-old Caucasian girl developed lipoatrophic areas on the abdomen and left thigh. Laboratory tests showed a partial IgA deficiency, circulating autoantibodies (ANAs, double- and single-stranded anti-DNAs, rheumatoid factor). The clinical aspect resembles lipodystrophia centrifugalis abdominalis infantilis, but autoimmune abnormalities suggest connective tissue panniculitis which underlines the overlap between the different forms of localized lipoatrophias.

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“…Der LEP besitzt kein typisches Autoantikörperprofil [20,22]. Bei lokalisierten Formen fehlen Autoantikörper häufig.…”

Section: Therapie Und Verlaufunclassified

“…Besteht gleichzeitig ein SLE, wird das Autoantikörperprofil von diesem bestimmt. Bislang wurden LEP-assoziiert ANA, dsDNS-Antikörper, ENA und Rheumafaktor nachgewiesen [6,9,19,20,22]. Wir haben bei unserem Patienten antineutrophile zytoplasmatische Antikörper (ANCA) gefunden, die u.W.…”

Section: Therapie Und Verlaufunclassified

“…In einer Untersuchung von Tuffanelli fanden sich in 73% ANA, in 31% anti-DNS-Antikörper, in 25% war der Rheumafaktor positiv, während Antikörper gegen extrahierbare nukleäre Antigene (ENA) nicht vorhanden waren [20]. Winkelmann beschreibt ein Autoantikörper-profil mit 67% ANA, 73% anti-DNS-Antikörpern, 60% ENA und 30% positivem Rheumafaktor beim LEP [22]. Ein Teil der Patienten hat keine Autoantikörper.…”

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ANCA-positiver Lupus erythematodes profundus

et al. 1998

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A 44-year-old male patient with lupus erythematosus profundus (lupus panniculitis) (LEP) of the right cheek/infraorbital region presented as a recurrent swelling. He had only anti-neutrophil-cytoplasmic antibodies (ANCA), which have not been previously described in association with LEP. There was no indication of systemic lupus erythematosus. While chloroquine produced no benefits, the skin lesions promptly cleared with dapsone. Step by step we reduced dapsone to a final dose of 50-75 mg per week. The ANCA titer decreased in parallel to the clinical improvement.

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Panniculitis in Connective Tissue Disease

Cited by 154 publications

References 57 publications

Lupus panniculitis involving the breast

Lupus panniculitis involving the breast

Localized Lipoatrophia with Persistent Circulating Autoantibodies and Partial Immunoglobulin A Deficiency in a Child

ANCA-positiver Lupus erythematodes profundus

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