Panniculitis caused by Mycobacterium monacense mimicking erythema induratum: a case in Ecuador

Romero, J.J.; Herrera, Pablo Pol; Cartelle, M.; Barba, Paolo Del; Tello, Susana Duce; Zurita, Jeannete

doi:10.1016/j.nmni.2016.01.006

Cited by 4 publications

(5 citation statements)

References 8 publications

(12 reference statements)

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“…Bacterial infection due to M. monacense is rarely reported in humans. The cases that have been reported so far have revealed that it is usually associated with dermatological and pulmonary infections, especially in immunosuppressed patients [2]. To the best of our knowledge, this is the first case report about thoracic spine osteomyelitis caused by M. monacense in the United States.…”

Section: Introductionmentioning

confidence: 74%

“…The first strain was isolated in 2006 by Reischl et al from a bronchial lavage sample in Germany [1]. We conducted a comprehensive literature search with the keywords "Mycobacterium monacense, thoracic spine infection, osteomyelitis, rapid growers of mycobacteria" on PubMed and Google Scholar, which returned a total of nine cases of M. monacense associated with human infections [1,2,[4][5][6][7], with none of them showing osteomyelitis of the thoracic spine. The incidence and prevalence of M. monacense are unknown as only a limited number of cases have been reported so far.…”

Section: Discussionmentioning

confidence: 99%

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A Rare Case of Mycobacterium Monacense Osteomyelitis: A Case Report

Ashraf¹,

Mendoza²,

Salman³

et al. 2021

Cureus

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Mycobacterium monacense (M. monacense) is a yellow-pigmented, rapidly growing non-tuberculous mycobacterium (RGM). It is a rare pathogen in humans, and only a very few cases of skin and lung infection related to it have been reported.In this report, we present the case of a 70-year-old Hispanic male who was brought to the hospital with back pain for 11 months. His physical exam on admission showed point tenderness in the lumbar and thoracic spine. MRI demonstrated severe spinal stenosis, discitis, and adjacent osteomyelitis at the T11-T12 vertebral bodies. Mycobacterium culture with fluorochrome smear from thoracic spine T12 tissue revealed mycobacterium species, but not Mycobacterium tuberculosis (M. tuberculosis). The final culture report led to the identification of M. monacense, which was confirmed by DNA sequencing. This case illustrates the rare manifestations of M. monacense and highlights the use of molecular biologic techniques to reach a definitive diagnosis in suspected cases.Infections caused by M. monacense are rarely reported in humans. Even though a few cases have reported M. monacense isolated from human samples, the clinical importance of it is not fully understood. A drug susceptibility test for antibiotic therapy is essential for this patient population. The interpretation of these cultures often generates unclear results. However, the aggravation of the disease on imaging and isolation of M. monacense alone from the cultured specimens obtained suggested that this pathogen may have caused the infection presented in this case.

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Section: Introductionmentioning

confidence: 74%

Section: Discussionmentioning

confidence: 99%

A Rare Case of Mycobacterium Monacense Osteomyelitis: A Case Report

Ashraf¹,

Mendoza²,

Salman³

et al. 2021

Cureus

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“…Despite an extensive search in English scientific literature, we could not find any other research reports of countries in South America on the prevalence of NTM lung infections. While Venezuela and Ecuador have reported multiple cases and outbreaks of skin and soft tissue infections caused by NTM, there is no documentation of any NTM lung disease cases in these countries [27][28][29][30][31][32][33].…”

Section: Discussionmentioning

confidence: 99%

First Case Reports of Nontuberculous Mycobacterial (NTM) Lung Disease in Ecuador: Important Lessons to Learn

Echeverría

Rueda

Espinoza³

et al. 2023

Pathogens

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Nontuberculous mycobacteria (NTM) lung infections are often misdiagnosed as tuberculosis, which can lead to ineffective antibiotic treatments. In this report, we present three cases of NTM lung infections in Ecuador that were initially diagnosed and treated as tuberculosis based on the results of sputum smear microscopy. The patients, all male, included two immunocompetent individuals and one HIV-positive subject. Unfortunately, sputum culture was not initiated until late in the course of the disease and the cause of the lung infection, Mycobacterium avium complex (MAC), was only identified after the patients had either passed away or were lost to follow-up. These cases are the first documented cases of NTM lung infections in the English medical literature from Ecuador. We emphasize the importance of accurate diagnosis of NTM infections by culture and identification to species level. Sputum smear staining alone cannot differentiate between mycobacterial species, which can lead to misidentification and ineffective treatments. Additionally, reporting NTM pulmonary disease as a notifiable disease to national TB control programs is recommended to obtain accurate prevalence data. These data are critical in determining the importance of this public health problem and the necessary actions needed to address it.

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“…monacense is not fully understood [6][7][8][9][10][11]. Among the nine cases, six strains were isolated from respiratory specimens, and the other clinical specimens were three biopsy samples of skin fistula tissue and hand and skin nodular lesions.…”

Section: Discussionmentioning

confidence: 99%

“…Different species of NTM can cause pulmonary infection, skin and soft tissue infection, bone and joint infection, lymphatic inflammation and catheter-related bacteraemia [3][4][5]. Mycobacterium monacense is a rapidly growing mycobacterium (RGM) that was first described in 2006; since then, several studies have reported the isolation of M. monacense from human clinical samples, such as skin, sputum, and soft tissues [6][7][8][9][10][11]. Here, we report the first case of Mycobacterium monacense isolated from the blood culture of a patient with severe pneumonia.…”

Section: Introductionmentioning

confidence: 99%

Case report: Mycobacterium monacense isolated from the blood culture of a patient with pulmonary infection

Yuan

Yang

et al. 2020

BMC Infect Dis

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Background: The poorly known mycobacterial species Mycobacterium monacense is a rapidly growing nontuberculous mycobacterium that was first described in 2006 (Reischl et al., Int J Syst Evol Microbiol 56:2575-8, 2006; it has been reported that its isolation is usually associated with skin and lung infections, especially in immunosuppressed patients (Hogardt et al., Jpn J Infect Dis 61:77-8, 2008; Taieb et al., J Hand Surg Am 33:94-6, 2008; Therese et al., Lung India 28:124-6, 2011; Shojaei et al., Ann Lab Med 32:87-90, 2012; Romero et al., New Microbes New Infect 10:112-5, 2016 ). The clinical significance of Mycobacterium monacense is not yet fully understood. Here, we report the first isolation of Mycobacterium monacense from the blood culture of a patient in China with severe pneumonia. Case presentation: On June 26, 2018, a 38-year-old man was admitted to the intensive care unit with breathing difficulty. One day prior, he was discovered with his face immersed in a small pond (non-chlorinated water) and with limb convulsions. He had undergone craniocerebral surgery after trauma 5 years earlier, which left him with epilepsy as a sequela. Bilateral diffuse ground-glass opacity was found in the lungs on chest X ray and chest CT image at admission. The result of the HIV serology test of the patient was negative. The patient was diagnosed with severe pneumonia. Drug-susceptible Klebsiella pneumoniae and Candida glabrata were isolated in the BALF, and yellow-pigmented colonies were isolated from blood cultures of the patient. The strain isolated from blood was identified by 16S rDNA sequencing as Mycobacteria monacense, which is a rapidly growing mycobacterium (RGM). The patient was treated with a combination of cefoperazone sulbactam, linezolid and voriconazole for 10 days, and the symptoms improved. During the one-year follow-up time, the patient did not relapse. Conclusions: We report the first case of M. monacense isolated from blood cultures in a patient with severe pneumonia, which provided evidence that the environmental microorganism possessed pathogenic characteristics.

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Panniculitis caused by Mycobacterium monacense mimicking erythema induratum: a case in Ecuador

Abstract: We report the first case of recently characterized species M. monacense associated with chronic nodular vasculitis, infecting a young woman. This case represents the first isolation of M. monacense from Ecuador. The isolate was identified by conventional and molecular techniques.

Cited by 4 publications

References 8 publications

A Rare Case of Mycobacterium Monacense Osteomyelitis: A Case Report

A Rare Case of Mycobacterium Monacense Osteomyelitis: A Case Report

First Case Reports of Nontuberculous Mycobacterial (NTM) Lung Disease in Ecuador: Important Lessons to Learn

Case report: Mycobacterium monacense isolated from the blood culture of a patient with pulmonary infection

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