Panniculitis associated with cutaneous T-cell lymphoma and cytophagocytic histiocytosis

Aronson, Iris K.; West, Dennis P.; Variakojis, Daina; Ronan, Salve G.; Iossifides, I.; Zeitz, H

doi:10.1111/j.1365-2133.1985.tb02296.x

Cited by 77 publications

(29 citation statements)

References 24 publications

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“…Furthermore, the clinical features of HPShave been attributed to the influence of cytokines produced by proliferating T cells and/or phagocytic histiocytes (19). However, CHP has been occasionally found in patients with B or T cell lymphomas (20,21). Peters and Winkelmann (20) reported a patient with cytophagic panniculitis who later developed B cell lymphoma.…”

Section: Chp Can Be Classified As a Hemophagocytic Syndrome (Hps)mentioning

confidence: 99%

Cytophagic Histiocytic Panniculitis Improved by Combined CHOP and Cyclosporin A Treatment.

et al. 1999

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In a 31-year-old Japanese man with cytophagic histiocytic panniculitis (CHP) remission was achieved by a combination of combined chemotherapy CHOPand cyclosporin A treatment. He was admitted to our hospital in January 1994 with recurrent high fever of 40.2°C and tender and violaceous subcutaneous nodules on his trunk, arms and legs. Hedeveloped pancytopenia, hemorrhagic diathesis, liver dysfunction. Histological examination of the biopsied subcutaneous nodule revealed a lobular panniculitis with fat necrosis and a massive infiltration of histiocytes phagocytosing nuclear debris. He was treated initially with 40 mg/day prednisolone. However, following a reduction in prednisolone dosage, his symptoms reappeared. CHOP(cyclophosphamide, doxorubicin, vincristine and prednisolone) therapy was then initiated. Three courses of CHOPtreatment alleviated his symptomsand cyclosporin A was used to maintain his condition for 15 months. His medication was then discontinued and he has been in complete remission for 10 months. Combined treatment of cyclosporin A and CHOPcombined chemotherapy was shown to be effective for this patient with severe CHP. (Internal Medicine 38: 296-301, 1999)

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Section: Chp Can Be Classified As a Hemophagocytic Syndrome (Hps)mentioning

confidence: 99%

Cytophagic Histiocytic Panniculitis Improved by Combined CHOP and Cyclosporin A Treatment.

et al. 1999

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“…Whether they predispose to the development of T-cell lymphoma is unclear although cutaneous T-cell lymphoma has been reported to occur concurrently with CHP. 6 Both patients responded well to cytotoxic therapy. The first case was lost to follow-up but the second case is alive and well, 41 months after initial presentation and 10 months after terminating treatment.…”

Section: Discussionmentioning

confidence: 97%

Cytophagic histiocytic panniculitis: A diagnostic dilemma

Cheah

Looi

Tan

et al. 1992

Hematological Oncology

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Cytophagic histiocytic panniculitis (CHP) is a recently recognized entity that frequently poses a perplexing diagnostic problem. Although the classical case presents with a relapsing fever, subcutaneous nodules, pancytopenia and liver dysfunction, most patients have in addition a multitude of other manifestations which confuse the clinical picture. Notwithstanding the variable clinical course, the disease frequently terminates in fatal hemorrhage. Diagnosis is based on histological features. A lobular panniculitis with an infiltrate of cytologically benign cytophagocytic histiocytes in skin nodules is the sine qua non of CHP. Hence, a deep skin biopsy which includes subcutaneous fat is mandatory to establish the diagnosis. Published information regarding this newly described entity remains scarce and we report two cases of CHP, one occurring in a 30-year-old Kadazan man and another in a 17-year-old Chinese woman seen at the University Hospital, Kuala Lumpur. The latter case presented with exudative ascites, an unusual feature, possibly due to intra-abdominal panniculitis. In addition, we record the development of cirrhosis in the same patient.

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“…Although usually present, angioinvasion is not required for a diagnosis of angiocentric T-cell lymphoma. 11 Secondary infection is common.…”

Section: Discussionmentioning

confidence: 99%

“…Patients with subcutaneous angiocentric T-cell lymphoma typically present with subcutaneous nodule or tumor masses, primarily affecting the extremities or trunk, and constitutional symptoms that include fever, malaise, fatigue, and weight loss. 11 Morphologically, the disease consists of a polymorphic lymphoid population with a broad cytologic spectrum. The neoplastic cells may range from small and slightly atypical to large cells with oval to convoluted nuclei and nucleoli.…”

Section: Discussionmentioning

confidence: 99%