Pankreasglucagon und Pathogenese des Diabetes mellitus

Hg, Dammann; Kühnau, J.; Drost, H.; Hw, Schreiber

doi:10.1055/s-0028-1129359

Cited by 1 publication

(4 citation statements)

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“…In the experiments reported here, neither gut glucagon nor pancreatic IRG responded to intravenous arginine infusion. These results are in good accordance with data reported by Muller et al (1974), Villanueva, Hedo andMarco (1976), Muller et al (1979), Damman et al (1978) and Botha et al (1977).…”

Section: Arginine Infusionsupporting

confidence: 93%

“…Small amounts of insulin might have suppressed arginine sensitive glucagon producing cells. However, Damman et al (1978) did not find any insulin immunoreactivity in sera of patients being deprived of insulin for 14 hours, and Muller et al (1979) did not find any detectable 3500 dalton glucagon after i.v. arginine even after three days of insulin deprivation.…”

Section: Arginine Infusionmentioning

confidence: 93%

“…Secretion studies conducted with pancreatectomized patients revealed contradictory results. So Barnes and Bloom (1976) did not find any glucagon in such patients, whereas Mtiller, Brennan, Tan and Aoki (1974) and Mtiller, Berger, Suter, Cuppers, Reiter, Wyss, Berchtold, Schmidt, Assal and Renold (1979) and Damman, Kiihnau, Drost and Schreiber (1978) found normal levels of immunoreactive glucagon using the pancreas specific antibody K 30.…”

Section: Introductionmentioning

confidence: 89%

“…There have been only a few reports on investigations in pancreatectomized patients (Mtiller et al 1974;Villanueva, Hedo and Marco 1976;Miyata, Yamamoyo, Yamaguchi, Nakao and Yoshida 1976;Palmer, Werner, Benson and Ensinck 1976;Damman et al 1978;Botha, Vinik, Child, Paul and Jackson 1977). Of these only Damman et al (1978) gave evidence for complete pancreatectomy by measuring C-Peptide levels under stimulation with arginine. In the present study we were able to demonstrate the importance of this test, since it revealed the presence of residual pancreatic tissue in one female patient, who by case history should have been totally duodenopancreatectomized.…”

Section: Pancreatectomymentioning

confidence: 99%

See 3 more Smart Citations

Glucagon Secretion in Four Duodenopancreatectomized Patients after Arginine and Glucose Load

Krause¹,

Thiel²,

Beyer³

et al. 1980

Horm Metab Res

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It is well established that in sera of totally duodenopancreatectomized dogs after complete insulin deprivation an immunoreactive glucagon can be found, which is indistinguishable from the pancreatic glucagon, and which can be stimulated by oral glucose and i.v. arginine as well. In four duodenopancreatectomized patients we found, after 26 h insulin deprivation, normal and elevated basal levels of IRG which were not stimulated by intravenous arginine but by oral glucose. Dilution tests of the sera before glucose stimulation showed immunological properties different from pancreatic standard glucagon, whereas in sera after stimulation immunoidentity with pancreatic standard glucagon could be demonstrated. Gel chromatography of the sera after stimulation yielded at least three immunoreactive peaks, the first over 30 000 daltons, a second eluting in the region of insulin, and a third of about 2000 daltons. True glucagon (3500 MW) could not be clearly demonstrated.

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Section: Arginine Infusionsupporting

confidence: 93%

Section: Arginine Infusionmentioning

confidence: 93%