Panic disorder and health-related quality of life: The predictive roles of anxiety sensitivity and trait anxiety

Kang, Eun-Ho; Kim, Borah; Choe, Ah Young; Lee, Jun Yeob; Choi, Tai Kiu; Lee, Sanghyuk

doi:10.1016/j.psychres.2014.10.029

Cited by 20 publications

(20 citation statements)

References 38 publications

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“…This is not unlike the wild running behavior mediated by the dorsal periaqueductal grey previously reported after acoustic startle (de Paulis and Hoshino, 2003, 2004). Chronic pain has been shown to be a predictor of panic attacks in patients (Smitherman et al, 2013; Kang et al, 2015). …”

Section: Discussionmentioning

confidence: 99%

Trigeminal Inflammatory Compression (TIC) injury induces chronic facial pain and susceptibility to anxiety-related behaviors

et al. 2015

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Our laboratory previously developed a novel neuropathic and inflammatory facial pain model for mice referred to as the Trigeminal Inflammatory Compression (TIC) model. Rather than inducing whole nerve ischemia and neuronal loss, this injury induces only slight peripheral nerve demyelination triggering long-term mechanical allodynia and cold hypersensitivity on the ipsilateral whisker pad. The aim of the present study is to further characterize the phenotype of the TIC injury model using specific behavioral assays (i.e. light-dark box, open field exploratory activity, and elevated plus maze) to explore pain- and anxiety-like behaviors associated with this model. Our findings determined that the TIC injury produces hypersensitivity 100% of the time after surgery that persists at least 21 weeks post injury (until the animals are euthanized). Three receptive field sensitivity pattern variations in mice with TIC injury are specified. Animals with TIC injury begin displaying anxiety-like behavior in the light-dark box preference and open field exploratory tests at week 8 post injury as compared to sham and naïve animals. Panic anxiety-like behavior was shown in the elevated plus maze in mice with TIC injury if the test was preceded with acoustic startle. Thus, in addition to mechanical and cold hypersensitivity, the present study identified significant anxiety-like behaviors in mice with TIC injury which resembling the clinical symptomatology and psychosocial impairments of patients with chronic facial pain. Overall, the TIC injury model’s chronicity, reproducibility, and reliability in producing pain- and anxiety-like behaviors demonstrate its usefulness as a chronic neuropathic facial pain model.

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Section: Discussionmentioning

confidence: 99%

Trigeminal Inflammatory Compression (TIC) injury induces chronic facial pain and susceptibility to anxiety-related behaviors

et al. 2015

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“…Many studies have reported low health-related quality of life and significant behavioral impairment in patients with PD. 2 Although less in number, structural magnetic resonance imaging (MRI) studies have also compared the brains of patients with PD and those of healthy subjects. Moreover, quantitative studies have detected a higher incidence of anatomical abnormalities in patients with PD, particularly in the fronto-temporal lobe and insula.…”

Section: Introductionmentioning

confidence: 99%

Reduced Cortical Thickness in the Temporal Pole, Insula, and Pars Triangularis in Patients with Panic Disorder

Kang

Lee

2017

Yonsei Med J

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PurposeRecent neuroimaging findings have revealed that paralimbic and prefrontal regions are involved in panic disorder (PD). However, no imaging studies have compared differences in cortical thickness between patients with PD and healthy control (HC) subjects.Materials and MethodsForty-seven right-handed patients with PD who met the diagnostic criteria in the Diagnostic and Statistical Manual of Mental Disorders-4th edition-text revision, and 30 HC subjects were enrolled. We used the FreeSurfer software package for estimating the cortical thickness of regions of interest, including the temporal pole, insula, and pars triangularis (mid-ventrolateral prefrontal cortex).ResultsCortical thickness of the temporal pole (p=0.033, right), insula (p=0.017, left), and pars triangularis (p=0.008, left; p=0.025, right) in patients with PD was significantly lower, compared with HC subjects (Benjamini-Hochberg false discovery rate correction). Exploratory analysis revealed a significant negative correlation between the cortical thickness of the right temporal pole and Beck Depression Inventory scores (r=-0.333, p=0.027) in patients with PD and positive correlations between the cortical thickness of the left pars triangularis and Panic Disorder Severity Scale (r=0.429, p=0.004), Anxiety Sensitivity Index-Revised (r=0.380, p=0.011), and Beck Anxiety Inventory (r=0.421, p=0.004) scores using Pearson's correlation.ConclusionOurs study is the first to demonstrate cortical thickness reduction in the temporal pole, insula, and pars triangularis in patients with PD, compared with the HC subjects. These findings suggest that reduced cortical thickness could play an important role in the pathophysiology of PD.

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“…Therefore, it was suggested that evaluation of quality of life in cases of panic disorder should include evaluation of the symptoms of the disease. 8 and the quality of life, as assessed using the German Kidscreen, 34 which is similar to PedsQL. They reported that impairment of the quality of life was strongly associated with internalizing rather than externalizing pathological conditions, according to both self-reports and parental reports, and they also found a relationship between mental disorders and impairment of the quality of life.…”

Section: Discussionmentioning

confidence: 99%

Family functioning and quality of life among children with anxiety disorder and healthy controls. A cross-sectional study

2018

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Panic disorder and health-related quality of life: The predictive roles of anxiety sensitivity and trait anxiety

Cited by 20 publications

References 38 publications

Trigeminal Inflammatory Compression (TIC) injury induces chronic facial pain and susceptibility to anxiety-related behaviors

Trigeminal Inflammatory Compression (TIC) injury induces chronic facial pain and susceptibility to anxiety-related behaviors

Reduced Cortical Thickness in the Temporal Pole, Insula, and Pars Triangularis in Patients with Panic Disorder

Family functioning and quality of life among children with anxiety disorder and healthy controls. A cross-sectional study

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