Panic as an Independent Risk Factor for Suicide Attempt in Depressive Illness

Katz, Curren; Yaseen, Zimri S.; Mojtabai, Ramin; Cohen, Lisa J.; Galynker, Igor

doi:10.4088/jcp.10m06186blu

Cited by 86 publications

(44 citation statements)

References 41 publications

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“…The partial items of the SS_ORP and HADS-A_ORP were related to symptoms of panic attack, such as dizziness, chest pain, shortness of breath, palpitation, a sort of frightened feeling, restless feeling, and sudden feelings of panic. MDD comorbid with panic attack or disorder is related to a poorer prognosis, such as an increased risk of suicide attempt and treatment-resistant depression [25,26,27]. This might be one of the possible reasons for our results.…”

Section: Discussionmentioning

confidence: 63%

Residual Symptoms Related to Physical and Panic Symptoms at Baseline Predict Remission of Depression at Follow-Up

et al. 2013

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Aims: The study aimed to investigate whether common residual symptoms at baseline were able to predict full remission of depression at 6-month and 2-year follow-up examinations in patients with major depressive disorder (MDD). Methods: This study enrolled 135 outpatients with MDD. The depression (DS) and somatic subscales (SS) of the Depression and Somatic Symptoms Scale and the depression and anxiety (HADS-A) subscales of the Hospital Anxiety and Depression Scale were used to investigate residual symptoms, which were divided into the common residual part (CRP) and the other residual part (ORP). Multivariate logistic regression was used to compare the ability to predict full remission between the CRP and ORP scores at baseline. Results: One hundred and nineteen and 106 outpatients completed the two follow-up examinations. The CRP of the DS and the ORP of the SS and HADS-A at baseline had a good ability to predict full remission among patients without pharmacotherapy. The three residual parts included physical and anxiety symptoms of depression and panic symptoms. Conclusions: Physicians should pay attention to physical, anxiety, and panic symptoms, because these symptoms are related to remission of depression. Future studies should explore how these symptoms affect the prognosis of depression.

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Section: Discussionmentioning

confidence: 63%

Residual Symptoms Related to Physical and Panic Symptoms at Baseline Predict Remission of Depression at Follow-Up

et al. 2013

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“…The first limitation is the uncertainty of the definition of suicidality itself in this study. Although the authors used the dichotomized score of the MINI-Plus suicide module similarly to previous studies [17,18,19], several past studies [12,44,45] have used a different definition of suicidality and have shown that different panic symptoms are associated with suicidal ideation versus a suicide attempt, and the severity of suicidal ideation is a rather weak predictor of suicide and suicide attempts. In the present study, 24 of 427 patients with PD (5.6%) reported a history of lifetime suicide attempts.…”

Section: Discussionmentioning

confidence: 99%

Clinical Symptoms Associated with Suicidality in Patients with Panic Disorder

Lim

Shin

et al. 2015

Psychopathology

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Background: Patients with panic disorder have higher rates of suicide than the general population. Among panic disorder subjects, early onset, female gender, alcohol abuse, and mood disorder increase the risk of suicidality. However, less is known about the unique relationships between discrete DSM-IV panic symptoms and higher suicidality. Therefore, in the current study we examined the panic symptom profile that is associated with higher suicidality in a sample of outpatients with panic disorder. Methods: This cross-sectional study included 427 patients diagnosed with current panic disorder on the basis of the DSM-IV-TR. In order to assess the contribution of the clinical variables, a univariate logistic regression was carried out examining the relationships between the demographic variables, suicidality from the suicide module of the Korean version of the MINI International Neuropsychiatric Interview Plus, and DSM-IV panic symptoms. Additionally, a multivariate logistic regression was performed to identify specific panic symptoms that were significant risk factors for suicidality among patients with current panic disorder. Results: We found that 74 (17.33%) panic disorder patients experienced high suicidality. Univariate analyses showed that high suicidality was significantly associated with a younger age (OR = 13.66; 95% CI 2.68-69.70), comorbid depressive disorders (OR = 4.57; 95% CI 2.57-8.11), and the following panic symptoms: palpitations (OR = 2.20; 95% CI 0.90-5.35), trembling (OR = 0.61; 95% CI 0.362-1.18), nausea or abdominal distress (OR = 1.77; 95% CI 0.96-3.27), fear of losing control or going crazy (OR = 2.18; 95% CI 1.12-4.23), and paresthesia (OR = 1.57; 95% CI 0.83-2.98). Multivariate logistic regression analyses demonstrated that specific panic symptoms, such as palpitations (adjusted OR = 2.69; 95% CI 1.08-6.73) and fear of losing control or going crazy (adjusted OR = 2.28; 95% CI 1.21-4.31), were related to suicidality after controlling for confounding factors. Conclusion: Some panic symptoms (e.g. palpitations and fear of losing control or going crazy) are associated with a risk of suicidality among patients with panic disorder. A priori identification of high-risk suicidal subjects could lead to effective treatment strategies for panic disorder.

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“…Our findings support earlier observations that comorbidity amplifies the risk of suicidality (Bolton et al 2008, Sareen et al 2005). Panic disorder is also known to be an independent risk factor for suicide attempts in depressive illness (Katz et al 2011). However, after multiple regression only obsessive-compulsive symptomatology significantly predicted suicidality in both sub-groups and the overall group, as well as depression in the overall group.…”

Section: Discussionmentioning

confidence: 99%