PANI: Ni(Leu)₂ based non-enzymatic electrochemical dopamine sensor

Abstract

In this study, Ni(Leu)2, Zn(Leu)2, Co(Leu)2, Cu(Leu)2, Ni(Trip) , Zn(Trip)2 2, Co(Trip)2, and Cu(Trip)2 were synthesized and used to prepare PANI-based nanocomposites (NCs) via a simple sonochemical method. These NCs were then used to fabricate non-enzymatic electrochemical voltammetric sensors for detecting dopamine (DOP). The results indicate that the PANI: Ni(Leu)2 sensor had a high sensitivity of 28.47 μAμM−1 cm−2 and a limit of detection (LOD) of 9.24 μM, while the PANI: Cu(Trip)2 sensor had a sensitivity of 20.27 μAμM−1 cm−2 and an LOD of 2.21 μM. Due to the use of Ni(Leu)2and Cu(Trip)2 compositions, the DOP detection sensitivity was higher in PANI: Ni(Leu)2 and PANI: Cu(Trip)2 based sensors, which can be explained by an enhanced redox mechanism. The PANI:Ni(Leu)2-based sensor is a particularly promising candidate for application in biomedical test kits due to its rapid detection.