Pangenome-wide association study reveals selective absence of CRISPR genes (Rv2816c-19c) in drug-resistantMycobacterium tuberculosis
Nikhil Bhalla,
Ranjan Kumar Nanda
Abstract:Background: The drug resistance development in Mycobacterium tuberculosis (Mtb) is attributed to the acquisition of mutations in the drug target genes. However, the role of the differential presence of non-essential accessory genes is relatively unexplored and Pan Genome-Wide Association Study (Pan-GWAS) can identify these gene sets that could contribute to drug resistance development in Mtb. Methodology: Publicly available Whole Genome Sequencing (WGS) data of clinical Mtb isolates (n=2601) from TB endemic co… Show more
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