Paneth cell maturation is related to epigenetic modification during neonatal–weaning transition

Baba, Ryoko; Kokubu, Keiji; Nakamura, Kenta; Fujita, Masato; Morimoto, Hiroyuki

doi:10.1007/s00418-022-02110-3

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“…Intestinal epithelial cells are classified either as absorptive (enterocyte) or secretory (goblet, Paneth, enteroendocrine, and tuft cells) (Noah et al 2011) (Baba et al 2022). Additionally, they sought to clarify the possibility of an "intermediate cell" occurring during the differentiation of goblet and paneth cells.…”

Section: Tales From the Cryptmentioning

confidence: 99%

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Taatjes

Roth

2022

Histochem Cell Biol

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Section: Tales From the Cryptmentioning

confidence: 99%

In focus in HCB

Taatjes

Roth

2022

Histochem Cell Biol

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In focus in HCB

Taatjes

Roth

2023

Histochem Cell Biol

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From birth to death: The hardworking life of Paneth cell in the small intestine

et al. 2023

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Paneth cells are a group of unique intestinal epithelial cells, and they play an important role in host-microbiota interactions. At the origin of Paneth cell life, several pathways such as Wnt, Notch, and BMP signaling, affect the differentiation of Paneth cells. After lineage commitment, Paneth cells migrate downward and reside in the base of crypts, and they possess abundant granules in their apical cytoplasm. These granules contain some important substances such as antimicrobial peptides and growth factors. Antimicrobial peptides can regulate the composition of microbiota and defend against mucosal penetration by commensal and pathogenic bacteria to protect the intestinal epithelia. The growth factors derived from Paneth cells contribute to the maintenance of the normal functions of intestinal stem cells. The presence of Paneth cells ensures the sterile environment and clearance of apoptotic cells from crypts to maintain the intestinal homeostasis. At the end of their lives, Paneth cells experience different types of programmed cell death such as apoptosis and necroptosis. During intestinal injury, Paneth cells can acquire stem cell features to restore the intestinal epithelial integrity. In view of the crucial roles of Paneth cells in the intestinal homeostasis, research on Paneth cells has rapidly developed in recent years, and the existing reviews on Paneth cells have mainly focused on their functions of antimicrobial peptide secretion and intestinal stem cell support. This review aims to summarize the approaches to studying Paneth cells and introduce the whole life experience of Paneth cells from birth to death.

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Paneth cell maturation is related to epigenetic modification during neonatal–weaning transition

Cited by 3 publications

References 35 publications

In focus in HCB

In focus in HCB

In focus in HCB

From birth to death: The hardworking life of Paneth cell in the small intestine

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