Paneth cell-like eosinophilic cytoplasmic granules in breast carcinoma

Huo, Lei; Bell, Diana; Qiu, Hongming; Şahin, Ayşegül; Wu, Yun; Sneige, Nour

doi:10.1016/j.anndiagpath.2010.08.007

Cited by 26 publications

(40 citation statements)

References 18 publications

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“…There have been 47 cases of breast AcCC reported in the English language literature, including the 2 new cases reported in this article [1,4,7–27]. A detailed morphologic description was provided in 31 of these cases [1,4,7–25].…”

Section: Resultsmentioning

confidence: 99%

“…A detailed morphologic description was provided in 31 of these cases [1,4,7–25]. Shimao et al [9] reported the only case of breast AcCC to date occurring in a male patient.…”

Section: Resultsmentioning

confidence: 99%

“…Follow-up data were available on 25 cases, with a median follow-up duration of 28 months (range, 6–185 months); 19 (76%) of the 25 cases had experienced no tumor recurrence at last review. Six patients developed metastasis to sites such as bone, liver, and lung [4,7,8,13], and 2 died of their disease [4,8]. …”

Section: Resultsmentioning

confidence: 99%

“…Most reported cases of breast AcCC describe variation in the tumor architecture, with solid and nested components admixed with areas of tubular and microglandular morphology. The phenomenon of tubules with central luminal extracellular “colloid-like” material was described as “MGA-like” in several articles [4,7,13], whereas other articles interpreted the appearance as suggestive of true MGA [22]. Interestingly, in 11 cases where collagen IV and laminin immunohistochemistry was performed, these MGA or MGA-like areas were entirely negative for these basement membrane markers in 8 cases [7,13,19,24].…”

Section: Resultsmentioning

confidence: 99%

“…In the remaining 3 cases [12] (including the 2 cases reported in this article), very focal positivity was noted. The cytologic appearance of tumor cells, with coarse eosinophilic granules and globules, was labeled “Paneth cell like” in 11 cases [4,7,16,19,22,24]. Seven cases also reported a population of cells with basophilic cytoplasm [4,11,19]; in 4 of these cases [4] (including case 2 from this article), cells with basophilic and eosinophilic cytoplasmic granules were located together within the same tubular structure, giving a variegated appearance (Fig.…”

Section: Resultsmentioning

confidence: 99%

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Acinic cell carcinoma of breast: morphologic and immunohistochemical review of a rare breast cancer subtype

et al. 2016

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Summary Acinic cell carcinoma of breast is a rare subtype of triple-negative breast carcinoma and demonstrates extensive morphologic overlap with acinic cell carcinoma of the salivary gland. In this study, we perform a detailed morphologic and immunohistochemical description of 2 cases of this rare entity and undertake a comprehensive review of all reported cases of breast acinic cell carcinoma in the English language literature to date. One-third of reported cases of breast acinic cell carcinoma have been associated with the presence of a ductal carcinoma not otherwise specified component, which is frequently poorly differentiated. Breast acinic cell carcinoma can demonstrate focal morphologic features similar to microglandular adenosis; these areas are frequently negative for collagen IV and laminin on immunohistochemistry. The true relationship between these 2 entities remains unclear, but we advocate that microglandular adenosis–like areas at the periphery of a breast acinic cell carcinoma should be considered part of the carcinomatous process and re-excised if this process extends to the initial surgical margins.

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Section: Resultsmentioning

confidence: 99%

“…A detailed morphologic description was provided in 31 of these cases [1,4,7–25]. Shimao et al [9] reported the only case of breast AcCC to date occurring in a male patient.…”

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

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Acinic cell carcinoma of breast: morphologic and immunohistochemical review of a rare breast cancer subtype

et al. 2016

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Unusual cerebrospinal fluid finding of intracytoplasmic granules in metaplastic carcinoma of the breast with acinar differentiation

Sardana

Parwani

Cui

et al. 2020

Diagnostic Cytopathology

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Cerebrospinal fluid (CSF) evaluation for total and differential cell count is a common practice in pathology for evaluation of various disease conditions. Although rare, these CSF samples yield interesting and unusual morphological findings, which are not only of academic interest, but also may play key roles in diagnosis. For diagnosing metastatic carcinoma in brain and meninges, CSF examination is one of the important tools along with imaging studies. Metaplastic breast carcinoma (MBC) encompasses a rare (<1% of all breast cancers), aggressive and highly heterogeneous group of tumors. MBC is almost always estrogen receptor, progesterone receptor and Her2 negative (triple negative) and shows frequent early distant metastases as well as sub‐optimal response to systemic therapies. The involvement of leptomeninges is most commonly associated with these triple‐ negative subtypes. In this report, we present an unusual case of malignant cells with prominent intracytoplasmic granules in CSF smears of a 46‐year‐old female with metastatic MBC with acinar differentiation. An extensive review of literature in English language did not return any other reports of a similar finding.

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The repertoire of somatic genetic alterations of acinic cell carcinomas of the breast: an exploratory, hypothesis‐generating study

Guerini-Rocco

Hodi

Piscuoglio

et al. 2015

The Journal of Pathology

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Acinic cell carcinoma (ACC) of the breast is a rare form of triple-negative (that is, estrogen receptor-negative, progesterone receptor-negative, HER2-negative) salivary gland-type tumor displaying serous acinar differentiation. Despite its triple-negative phenotype, breast ACCs are reported to have an indolent clinical behavior. Here, we sought to define whether ACCs have a mutational repertoire distinct from that of other triple-negative breast cancers (TNBCs). DNA was extracted from microdissected formalin-fixed paraffin-embedded sections of tumor and normal tissue from two pure and six mixed breast ACCs. Each tumor component of the mixed cases was microdissected separately. Tumor and normal samples were subjected to targeted capture massively parallel sequencing targeting all exons of 254 genes, including genes most frequently mutated in breast cancer and related to DNA repair. Selected somatic mutations were validated by targeted amplicon resequencing and Sanger sequencing. Akin to other forms of TNBC, the most frequently mutated gene found in breast ACCs was TP53 (one pure and six mixed cases). Additional somatic mutations affecting breast cancer-related genes found in ACCs included PIK3CA, MTOR, CTNNB1, BRCA1, ERBB4, ERBB3, INPP4B and FGFR2. Copy number alteration analysis revealed complex patterns of gains and losses similar to those of common forms of TNBCs. Of the mixed cases analyzed, identical somatic mutations were found in the acinic and the high-grade non-acinic components in two out of four cases analyzed, providing evidence of their clonal relatedness. In conclusion, breast ACCs display the hallmark somatic genetic alterations found in high-grade forms of TNBC, including complex patterns of gene copy number alterations and recurrent TP53 mutations. Furthermore, we provide circumstantial genetic evidence to suggest that ACCs may constitute the substrate for the development of more aggressive forms of triple-negative disease.

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Paneth cell-like eosinophilic cytoplasmic granules in breast carcinoma

Cited by 26 publications

References 18 publications

Acinic cell carcinoma of breast: morphologic and immunohistochemical review of a rare breast cancer subtype

Acinic cell carcinoma of breast: morphologic and immunohistochemical review of a rare breast cancer subtype

Unusual cerebrospinal fluid finding of intracytoplasmic granules in metaplastic carcinoma of the breast with acinar differentiation

The repertoire of somatic genetic alterations of acinic cell carcinomas of the breast: an exploratory, hypothesis‐generating study

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