Pandemics of the 21st Century: The Risk Factor for Obese People

Hancková, Miriam; Betáková, Tatiana

doi:10.3390/v14010025

Cited by 22 publications

(17 citation statements)

References 142 publications

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“…Obesity is associated with unemployment, social disadvantages, and reduced socioeconomic productivity, thus increasingly creating an economic burden [3]. Furthermore, obesity has been shown to play an important role in the pathophysiology of numerous chronic diseases which include cardiovascular disease (CVD), dyslipidemias, type 2 diabetes (T2D), and cancer [4][5][6]. The fifth risk for attributable deaths in females was high body mass index (hBMI), while for the males, hBMI accounts for the sixth risk attributed to death in 2019 [7].…”

Section: Introductionmentioning

confidence: 99%

Erchen Decoction Ameliorates the Metabolic Abnormalities of High-Fat Diet-Fed Rats

Cheng

Zhang

et al. 2022

Computational and Mathematical Methods in Medicine

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Objective. Brown adipose tissue (BAT) dissipates chemical energy to protect against obesity. In the present study, we aimed to determine the effects of Erchen decoction on the lipolysis and thermogenesis function of BAT in high-fat diet-fed rats. Methods. Sprague-Dawley rats were randomly divided into four groups, which were fed a control diet (C) or a high-fat diet (HF), and the latter was administered with high and low doses of Erchen decoction by gavage once a day, for 12 weeks. Body weight, the serum lipid profile, serum glucose, and insulin levels of the rats were evaluated. In addition, the phosphorylation and protein and mRNA expression of AMP-activated protein kinase (AMPK), adipose triglyceride lipase (ATGL), peroxisome proliferator-activated receptor γ coactivator- (PGC-) 1α, and uncoupling protein 1 (UCP-1) in BAT were measured by immunoblotting and RT-PCR. Results. Erchen decoction administration decreased body weight gain and ameliorated the abnormal lipid profile and insulin resistance index of the high-fat diet-fed rats. In addition, the expression of p-AMPK and ATGL in the BAT was significantly increased by Erchen decoction. Erchen decoction also increased the protein and mRNA expression of PGC-1α and UCP-1 in BAT. Conclusion. Erchen decoction ameliorates the metabolic abnormalities of high-fat diet-fed rats, at least in part via activation of lipolysis and thermogenesis in BAT.

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Section: Introductionmentioning

confidence: 99%

Erchen Decoction Ameliorates the Metabolic Abnormalities of High-Fat Diet-Fed Rats

Cheng

Zhang

et al. 2022

Computational and Mathematical Methods in Medicine

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“…This is consistent with the result of a review of 70 published studies that showed a reduction in weight, body mass and fat percentage in fasted people with obesity ( 8 ). Previous reports showed that weight loss during RIF was due to the reduced food intake ( 2 ). Therefore, this could, in part, explain the observed weight loss in the present study.…”

Section: Discussionmentioning

confidence: 97%

“…Obesity has become a global public health issue with almost two billion individuals were overweight ( 1 ). Obesity is a global epidemic in developed countries and is associated with several comorbidities such as cardiovascular disease, type 2 diabetes and cancer ( 2 , 3 ). It has been reported that more than one-third of children and adolescents are with obesity ( 4 ).…”

Section: Introductionmentioning

confidence: 99%

Exergaming During Ramadan Intermittent Fasting Improve Body Composition as Well as Physiological and Psychological Responses to Physical Exercise in Adolescents With Obesity

et al. 2022

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The effects of exergaming on biochemical responses has been investigated; however, no data is available for this effect during Ramadan intermittent fasting (RIF). RIF is a daily fasting characterized by abstaining from eating and drinking from sunrise to sunset for 29–30 days. The purpose of this study was to investigate the effect of exergaming during RIF on body composition, physical performance and hematological parameters in overweight and adolescents with obesity. Twenty-four adolescents with obesity were divided into two groups [control group (CG), n = 12, or cooperative sport exergaming group (EG), n = 12: 45 min per session during five days per week)]. Participants completed a 6-min walking test (6MWT), a squat jump test and a 10 and a 30m sprint tests in four different occasions: before Ramadan (T0), the second week of Ramadan (T1), the fourth week of Ramadan (T2), and after Ramadan (T3). Blood pressure, rating of perceived exertion (RPE), body composition, central obesity index, dietary intake and profile of mood states (POMS) were, also, assessed over the four periods. The results showed that body weight, body mass index and body fat percentage were significantly lower at T2 compared to T0 and T1 in the EG. After RIF, body composition returned to the values recorded before RIF. The POMS score was significantly lower during T2 compared to T0, T1 and T3 in the EG. The vertical jump and the 6MWT distance were significantly higher (i) at T2 compared to T0, T1 and T3 in the EG and (ii) in EG compared to CG at T2. RPE was significantly lower (i) at T2 compared to T0, T1 and T3 in the EG and (ii) in EG compared to CG at T2. Blood pressure was lower during T2 compared to the other periods in EG. The EG experienced significant decreases in total cholesterol and triglycerides during T2. However, no significant changes between groups and periods was reported for all the other parameters. In conclusion, exergaming during RIF has a positive effect on body composition and physiological and psychological responses in adolescents with obesity.

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“…Humanity has survived many severe pandemics previously [12][13][14]. In the last four decades, humankind has faced several deadly viral outbreaks, such as human immunodeficiency virus (HIV), severe acute respiratory syndrome coronavirus (SARS-CoV), H1N1 influenza virus, Middle East respiratory syndrome coronavirus (MERS-CoV), Ebola, and severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) [12,[14][15][16][17].…”

Section: Introductionmentioning

confidence: 99%

Polysaccharides and Their Derivatives as Potential Antiviral Molecules

Claus-Desbonnet

Nikly

Nalbantova

et al. 2022

Viruses

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In the current context of the COVID-19 pandemic, it appears that our scientific resources and the medical community are not sufficiently developed to combat rapid viral spread all over the world. A number of viruses causing epidemics have already disseminated across the world in the last few years, such as the dengue or chinkungunya virus, the Ebola virus, and other coronavirus families such as Middle East respiratory syndrome (MERS-CoV) and severe acute respiratory syndrome (SARS-CoV). The outbreaks of these infectious diseases have demonstrated the difficulty of treating an epidemic before the creation of vaccine. Different antiviral drugs already exist. However, several of them cause side effects or have lost their efficiency because of virus mutations. It is essential to develop new antiviral strategies, but ones that rely on more natural compounds to decrease the secondary effects. Polysaccharides, which have come to be known in recent years for their medicinal properties, including antiviral activities, are an excellent alternative. They are essential for the metabolism of plants, microorganisms, and animals, and are directly extractible. Polysaccharides have attracted more and more attention due to their therapeutic properties, low toxicity, and availability, and seem to be attractive candidates as antiviral drugs of tomorrow.

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Pandemics of the 21st Century: The Risk Factor for Obese People

Cited by 22 publications

References 142 publications

Erchen Decoction Ameliorates the Metabolic Abnormalities of High-Fat Diet-Fed Rats

Erchen Decoction Ameliorates the Metabolic Abnormalities of High-Fat Diet-Fed Rats

Exergaming During Ramadan Intermittent Fasting Improve Body Composition as Well as Physiological and Psychological Responses to Physical Exercise in Adolescents With Obesity

Polysaccharides and Their Derivatives as Potential Antiviral Molecules

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