Pandemic-Related Changes in Incidence and Mortality Rates of Gastrointestinal Cancers During 2020

Murphy, Caitlin C.; Tavakkoli, Anna; Wani, Sachin; Singal, Amit G.

doi:10.14309/ajg.0000000000002526

Cited by 1 publication

(1 citation statement)

References 13 publications

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“…Digestive system cancers pose a significant global health challenge due to their high incidence and mortality rates [1][2][3][4][5]. Epidemiological analyses demonstrated that digestive system cancers, encompassing malignancies of the oesophagus, stomach, liver, pancreas, colon and rectum, significantly contribute to the overall health burden worldwide [6][7][8]. Recent advancements in endoscopic techniques and minimally invasive surgery have greatly improved the outcomes and quality of life for individuals diagnosed with early-stage digestive system cancers [9][10][11][12][13].…”

Section: Introductionmentioning

confidence: 99%

Unravelling the role of intratumoral bacteria in digestive system cancers: current insights and future perspectives

Lu,

Aihaiti,

Abudukeranmu

et al. 2024

J Transl Med

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Recently, research on the human microbiome, especially concerning the bacteria within the digestive system, has substantially advanced. This exploration has unveiled a complex interplay between microbiota and health, particularly in the context of disease. Evidence suggests that the gut microbiome plays vital roles in digestion, immunity and the synthesis of vitamins and neurotransmitters, highlighting its significance in maintaining overall health. Conversely, disruptions in these microbial communities, termed dysbiosis, have been linked to the pathogenesis of various diseases, including digestive system cancers. These bacteria can influence cancer progression through mechanisms such as DNA damage, modulation of the tumour microenvironment, and effects on the host’s immune response. Changes in the composition and function within the tumours can also impact inflammation, immune response and cancer therapy effectiveness. These findings offer promising avenues for the clinical application of intratumoral bacteria for digestive system cancer treatment, including the potential use of microbial markers for early cancer detection, prognostication and the development of microbiome-targeted therapies to enhance treatment outcomes. This review aims to provide a comprehensive overview of the pivotal roles played by gut microbiome bacteria in the development of digestive system cancers. Additionally, we delve into the specific contributions of intratumoral bacteria to digestive system cancer development, elucidating potential mechanisms and clinical implications. Ultimately, this review underscores the intricate interplay between intratumoral bacteria and digestive system cancers, underscoring the pivotal role of microbiome research in transforming diagnostic, prognostic and therapeutic paradigms for digestive system cancers.

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