Pandemic influenza in Canadian children: A summary of hospitalized pediatric cases

Bettinger, Julie A.; Sauvé, Laura; Scheifele, David W.; Moore, Dorothy; Vaudry, Wendy; Tran, Dat; Halperin, Scott A.; Pelletier, Louise

doi:10.1016/j.vaccine.2010.02.044

Cited by 67 publications

(92 citation statements)

References 9 publications

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“…We found that during the pandemic period 17% of overall pH1N1 infected cases were children ( < 12 years). This observation agrees with the published data from China and neighboring countries [7,21] but is in contrast with that of North America where pediatric infections were more prevalent [22,23].…”

Section: Discussionsupporting

confidence: 92%

Genetic and clinical assessment of 2009 pandemic influenza in southern China

Farooqui

Lei

Wang

et al. 2011

J Infect Dev Ctries

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Introduction: South China has a proven role in the global epidemiology of previous influenza outbreaks due to its dual seasonal pattern. We present the virologic, genetic and clinical characterization of pandemic H1N1 influenza infection (pH1N1) in Shantou and Nanchang, cities in southern China, during the second wave of the 2009-2010 pandemic. Methodology: Nasopharyngeal swabs were collected from 165 individuals with influenza-like illness (ILI) who presented to the hospitals in Shantou and Nanchang. Laboratory diagnosis and characterization was performed by real-time PCR, virus isolation in embryonated chicken eggs, and sequencing. Results: pH1N1 activity was sustained in three different temporal patterns throughout the study period. The overall positivity rate of pH1N1 was 50% with major distribution among young adults between the ages of 13 and 30 years. High fever, cough, expectoration, chest pain, myalgia, nasal discharge and efficient viral replication were observed as major clinical markers whereas a substantial number of afebrile cases (17%) was also observed. Rate of hospitalization and disease severity (39%) and recovery (100%) were also high within the region. Furthermore, severe complications were likely to develop in young adults upon pH1N1 infection. Genetic characterization of the HA and NA genes of pH1N1 strains exhibited homogenous spread of pH1N1 strains with 99% identity with prototypic strains; however, minor unique mutations were also observed in the HA gene. Conclusion: The study illustrates the detailed characteristics of 2009 influenza pandemic in southern parts of China that might help to strategize preparedness for future pandemics and subsequent influenza seasons.

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Section: Discussionsupporting

confidence: 92%

Genetic and clinical assessment of 2009 pandemic influenza in southern China

Farooqui

Lei

Wang

et al. 2011

J Infect Dev Ctries

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“…After screening 787 titles and abstracts and 164 full‐text articles, 48 cohort studies plus 14 companion reports met eligibility criteria and were included 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30, 31, 32, 33, 34, 35, 36, 37, 38, 39, 40, 41, 42, 43, 44, 45, 46, 47, 48, 49, 50, 51, 52, 53, 54, 55, 56, 57, 58, 59, 60, 61, 62, 63, 64, 65, 66, 67, 68, 69, 70, 71, 72, 73. These studies examined H1N1 between March 1, 2009 and October 24, 2010, and the most common factor of social disadvantage reported was ethnic minority status (36/48 studies), except in 12 studies that considered H1N1‐infected patients from LIC/LMIC, which were analyzed separately for each country (one study from Guatemala,57 two from Morocco,60, 61 one from Pakistan,73 and eight from India, plus four companion reports) 60, …”

Section: Resultsmentioning

confidence: 99%

“…The outcome of hospitalization was reported in 24 studies 19, 20, 21, 23, 25, 27, 31, 32, 34, 35, 36, 37, 38, 39, 40, 43, 44, 45, 49, 52, 54, 55, 56. Two studies reported hospitalizations among ethnic minorities compared to nonethnic minorities in high‐income economy countries (HIC), and a significantly greater proportion of ethnic minority patients were hospitalized versus nonethnic minority patients (OR 2·26, 95% CI: 1·53–3·32, Table 1 ) 20, 29.…”

Section: Resultsmentioning

confidence: 99%

Impact of H1N1 on socially disadvantaged populations: summary of a systematic review

Tricco

Lillie

Soobiah

et al. 2013

Influenza Resp Viruses

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BackgroundPrevious reviews found that the H1N1 pandemic was associated with a large proportion of hospitalizations, severe illness, workplace absenteeism, and high costs. However, the burden among socially disadvantaged groups of the population is unclear. This is a summary of a previously published systematic review commissioned by the World Health Organization on the burden of H1N1 pandemic (influenza A/Mexico/2009 (H1N1)) among socially disadvantaged populations.Methods MEDLINE and EMBASE were searched to identify studies reporting hospitalization, severe illness, and mortality attributable to the 2009 H1N1 pandemic among socially disadvantaged populations, including ethnic minorities and low‐income or lower‐middle‐income economy countries (LIC/LMIC). SAS and Review Manager were used to conduct random effects meta‐analysis.ResultsForty‐eight cohort studies and 14 companion reports including 44 777 patients were included after screening 787 citations and 164 full‐text articles. Twelve of the included studies provided data on LIC/LMIC, including one study from Guatemala, two from Morocco, one from Pakistan, and eight from India, plus four companion reports. The rest provided data on ethnic minorities living in high‐income economy countries (HIC). Significantly more hospitalizations were observed among ethnic minorities versus nonethnic minorities in two North American studies [1313 patients, odds ratio (OR) 2·26 (95% confidence interval: 1·53–3·32)]. Among hospitalized patients in HIC, statistically significant differences in intensive care unit admissions (n = 8 studies, 15 352 patients, OR 0·84 [0·69–1·02]) and deaths (n = 6 studies, 14 757 patients, OR 0·85 [95% CI: 0·73–1·01]) were not observed.ConclusionWe found significantly more hospitalizations among ethnic minorities versus nonethnic minorities in North America, yet no differences in intensive care unit admissions or deaths among H1N1‐infected hospitalized patients were observed in North America and Australia. Our results suggest a similar burden of H1N1 between ethnic minorities and nonethnic minorities living in HIC.

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“…Kanada"da yapılan benzer bir çalışmada ise Tartışma olguların %17"sinin mevsimsel influenza aşısı yaptırdığı görülmüştür. H1N1v negatif hastalarda ise her iki aşının da olmadığı tespit edilmiştir (19). Bu sonuç, bazı ülkelerde olduğu gibi ülkemizde de mevsimsel influenza aşısına genel eğilimi yansıtması açısından önemlidir.…”

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“…Bettinger ve arkadaşlarının yaptığı bir çalışmada ise influenza tanısı ile yatırılan 235 çocuk vakadan %17,5"inin yoğun bakım ihtiyacı olduğu, bunların %38"inin mekanik ventilatör desteği aldığı ve iki vakanın kaybedildiği bildirilmiştir (19). Ülkemizde yapılan bir çalışmada ise vakaların beş tanesi (%13,5) yoğun bakımda izlenmiş ve dört tanesi kaybedilmiştir (20).…”

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Epidemiological and Clinical Characteristics of Pandemic Influenza A (H1N1)v Infection Among the Children Admitted to Suleyman Demirel University

Özen¹,

Elmas²,

Tepeli³

et al. 2012

J Turgut Ozal Med Cent

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Epidemiological and Clinical Characteristics of Pandemic Influenza A (H1N1)v Infection Among the Children Admitted to Süleyman Demirel UniversityAbstract Aim: We aimed to evaluate the clinical and epidemiological features of the patients that were admitted to Suleyman Demirel University Medical Faculty Pediatric Department, for whom the pre-diagnosis was H1N1v. Material and Methods: Demographic characteristics, clinical findings, laboratory tests results and radiological evaluations of 64 patients who were admitted to Suleyman Demirel University Medical Faculty Pediatric Department with pre-diagnosis of H1N1v were analyzed and evaluated. Findings: Average age of the patients who were admitted and observed with pre-diagnosis of pandemic influenza, was 32,4 months (1-188 months) and 34% (n=22) of the cases were female. Nine of the patients (14%) were confirmed for final diagnosis as H1N1v. Most common complaints during admission were cough (85,9%), fever (68,%) and weakness (57,8%). Five of the patients (55%) that are H1N1v positive had preexisting diseases. Five patients needed intensive care unit during the observation and treatment. Two (22,2%) of them did not survive. Results: Clinical findings of pandemic influenza and seasonal influenza are quite similar. Preexisting diseases increase the rates of morbidity and mortality.

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Pandemic influenza in Canadian children: A summary of hospitalized pediatric cases

Cited by 67 publications

References 9 publications

Genetic and clinical assessment of 2009 pandemic influenza in southern China

Genetic and clinical assessment of 2009 pandemic influenza in southern China

Impact of H1N1 on socially disadvantaged populations: summary of a systematic review

Epidemiological and Clinical Characteristics of Pandemic Influenza A (H1N1)v Infection Among the Children Admitted to Suleyman Demirel University

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