Pandemic 2009 H1N1 influenza virus vaccination in lung transplant recipients: Coverage, safety and clinical effectiveness in the Zurich cohort

Clinical features and outcomes of influenza infections in lung transplant recipients: a single‐season cohort study

“…This is a retrospective observational study of influenza virus infections diagnosed in the Zurich University Hospital Lung Transplantation Program (ZUHLTP) cohort during 1 influenza season. Follow‐up of LTRs in this cohort was conducted at the ZUHLTP as previously described . In general, all LTRs 3 or more months after transplantation are offered influenza vaccination every autumn.…”

“…For LTRs, these studies are limited to case series and cohort investigations with small patient numbers. During the A/H1N1 pandemic (2009/2010), 7 LTRs were diagnosed with influenza A/H1N1 in our cohort and 2 of these had PVS . Therefore, we were aware of this phenomenon and routinely assessed all subsequent influenza infections by serial weekly sampling.…”

Adjuvanted (AS03) A/H1N1 2009 Pandemic Influenza Vaccines and Solid Organ Transplant Rejection: Systematic Signal Evaluation and Lessons Learnt

“…One published report also described SOT rejection in one pancreas transplant recipient immunised with a non-GSK adjuvanted vaccine [17]. By contrast, other studies conducted in Switzerland, Belgium, Spain, Germany and Canada in patients with lung [18], kidney [19, 20], liver [21], pancreas and heart transplants [22, 23] reported no evidence of increased risk of rejection. Most of this research evaluated antibody responses to the vaccines and overall safety, rather than clinical rejection as an outcome.…”

Update on viral infections in lung transplantation

“…In general, Flu vaccination was well tolerated and the clinical effectiveness was good [30]. Yet a more detailed analysis concerning the rate of immune suppression and 'vaccine take' is needed to address this important topic, since immune suppression impacts on Flu vaccine immunogenicity [31].…”