Pandanus conoideus Lam. Pandanaceae

Keim, Ary Prihardhyanto; Sujarwo, Wawan

doi:10.1007/978-3-030-38389-3_172

Cited by 2 publications

(3 citation statements)

References 8 publications

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“…In Papua, Red Fruit is one of the traditional foods by the people of Wamena, Papua (F. C. Dewi et al, 2022;Zebua et al, 2019), this fruit is called kuansu. Its scientific name is Pandanus Conoideus because the Red Fruit plant belongs to the pandan-pandanus family with trees resembling pandanus (Keim & Sujarwo, 2021;Walujo et al, 2007). One of these traditional medicines comes from the red fruit plant as a medicinal plant that has good prospects for development.…”

Section: Red Fruit On the Growth Of Granulation Tissuementioning

confidence: 99%

Utilization of Red Fruit on The Growth of Tissue Granulation in Diabetic Wounds

Tondok,

Tafor,

Ruben

et al. 2023

jppipa, pendidikan ipa, fisika, biologi, kimia

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The utilization of red fruit on the growth of granulation tissue in diabetic wounds aims to determine the benefits of red fruit which have been scientifically proven through research in Indonesia. Methods: Conducting a literature search using the Google Scholar application and conducting an analysis of the literature included in the inclusion criteria. Results: From the search results and research results which conclude about the benefits of red fruit. Conclusion: The benefits of red fruit on the growth of granulation tissue in diabetic wounds, namely red fruit contains carotene (12,000 ppm), beta-carotene (700 ppm), tocopherol (11,000 ppm). The benefits of red fruit on the growth of granulation tissue also affect diabetic wound healing because granulation tissue is the growth of new tissue that occurs when a wound is undergoing a healing process, consisting of new capillaries and fibroblast cells that fill the cavity. Granulation tissue formation is an important step in the proliferative and healing phase of the wound. Granular tissue is a reddish network that contains capillaries at the base of the wound

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Section: Red Fruit On the Growth Of Granulation Tissuementioning

confidence: 99%

Utilization of Red Fruit on The Growth of Tissue Granulation in Diabetic Wounds

Tondok,

Tafor,

Ruben

et al. 2023

jppipa, pendidikan ipa, fisika, biologi, kimia

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“…It is found in primary rainforests or mixed deciduous forests of Southeast Asia (Indonesia, Thailand, and Malaysia), Africa, and the northeastern region of India (Ahmad et al, 2016). T. crispa has a variety of local names that follow the language of the region where it grows, including Brotowali, Antawali, and Andawali (Indonesia); Petawali and Akar Seruntum (Malaysia); Giloya (India); Makabuhay, Panyawan, and Manunggal (Philippines) (Heyne, 1987; Keim & Sujarwo, 2021). The synonym names were diverse, including Menispermum crispum L.; Menispermum rimosum (Blume) Spreng.…”

Section: Introductionmentioning

confidence: 99%

“…Empirically, it has been commonly used in traditional medicine to treat various health conditions. In Indonesia, since the early 20th century, the decoction of T. crispa stems has been empirically reported for the therapy of diabetes mellitus as well as a postpartum remedy and muscle pain treatment (Heyne, 1987; Keim & Sujarwo, 2021). In Thailand, the decoction from the stem of T. crispa has been used as an antipyretic, anti-inflammatory, and appetite enhancer (Ahmad et al, 2016).…”

Section: Introductionmentioning

confidence: 99%

Exploration of the main active metabolites fromTinospora crispa(L.) Hook. f. & Thomson stem as insulin sensitizer in L6.C11 skeletal muscle cell by integratingin vitro, metabolomics, and molecular docking

Zuhri,

Yuliana,

Fadilah

et al. 2023

Preprint

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Ethnopharmacological relevance: Tinospora crispa (L.) Hook. f. & Thomson stem (TCS) has long been used as folk medicine for the treatment of diabetes mellitus. Previous study revealed that TCS possesses multi-ingredients and multi-targets characteristic potential as insulin sensitizer activity. However, its mechanisms of action and molecular targets are still obscure. Aim of the study: In the present study, we investigated the effects of TCS against insulin resistance in muscle cells through integrating in vitro experiment and identifying its active biomarker using metabolomics and in molecular docking validation. Materials and methods: We used centrifugal partition chromatography (CPC) to isolate 33 fractions from methanolic extract of TCS, and then used UHPLC-Orbitrap-HRMS to identify the detectable metabolites in each fraction. We assessed the insulin sensitization activity of each fraction using enzyme-linked immunosorbent assay (ELISA), and then used confocal immunocytochemistry microscopy to measure the translocation of glucose transporter 4 (GLUT4) to the cell membrane. The identified active metabolites were further simulated for its molecular docking interaction using Autodock Tools. Results: The polar fractions of TCS significantly increased insulin sensitivity, as measured by the inhibition of phosphorylated insulin receptor substrate-1 (pIRS1) at serine-312 residue (ser312) also the increasing number of translocated GLUT4 and glycogen content. We identified 58 metabolites of TCS, including glycosides, flavonoids, alkaloids, coumarins, and nucleotides groups. The metabolomics and molecular docking simulations showed the presence of minor metabolites consisting of tinoscorside D, higenamine, and tinoscorside A as the active compounds. Conclusions: Our findings suggest that TCS is a promising new treatment for insulin resistance and the identification of the active metabolites in TCS could lead to the development of new drugs therapies for diabetes that target these pathways. Keywords: Insulin sensitivity, metabolomics, type 2 diabetes, serine phosphorylation, natural product, Menispermaceae.

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Pandanus conoideus Lam. Pandanaceae

Cited by 2 publications

References 8 publications

Utilization of Red Fruit on The Growth of Tissue Granulation in Diabetic Wounds

Utilization of Red Fruit on The Growth of Tissue Granulation in Diabetic Wounds

Exploration of the main active metabolites fromTinospora crispa(L.) Hook. f. & Thomson stem as insulin sensitizer in L6.C11 skeletal muscle cell by integratingin vitro, metabolomics, and molecular docking

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