Pancytopenýa and Sepsýs due to Meropenem: A Case Report

Abstract

Meropenem is one of the most commonly used antibacterial agents

Acute thrombocytopenia due to meropenem: a case report

“…The patient should be monitored for any bleeding tendencies and blood counts should be done regularly. 1 An accelerated decrease in platelet count in presence of the potential drug is mostly of immune origin. 1 In our case report, we have described a patient who developed acute thrombocytopenia on i.v.…”

“…1 An accelerated decrease in platelet count in presence of the potential drug is mostly of immune origin. 1 In our case report, we have described a patient who developed acute thrombocytopenia on i.v. administration of meropenem after a single dose of 1 gm.…”

“…An administered drug which is thought to be the offending agent is stopped and the recovery of platelet count on discontinuation provides evidence that the DITP was due to the drug. 1 The management of DITP is done by cessation of the offending agent and platelet transfusion if required. In our case, meropenem was stopped and alternative antimicrobial was started.…”

“…Rare adverse effects (<1%) are agranulocytosis, angioedema, hypersensitivity reaction, leukopenia, neutropenia, pancytopenia, etc. 1 We report a case of meropenem induced thrombocytopenia in a 57 year old man.…”

“…Meropenem is also used as empirical therapy prior to identification of organisms and is well tolerated in severe bacterial infections. 1,2 Meropenem has activity against gram-positive, gram-negative and anaerobic bacteria and is primarily used in polymicrobial and nosocomial infections. 2 The most common adverse effects (1-10%) are diarrhoea, nausea and vomiting, rash, headache, constipation, sepsis, thrombophlebitis, etc.…”