Pancytopenia and nephrotic syndrome related to autoimmune hypothyroidism

Rathi, Manjusha; Peacey, Steven R.

doi:10.1258/shorts.2011.011029

Cited by 7 publications

(6 citation statements)

References 12 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…It is hypothesized that an autoimmune reaction can be the causative factor of pancytopenia in hypothyroidism, but its dissociation with thyroid peroxidase antibody makes it less likely. Marrow hypoplasia causing pancytopenia has also been suggested as a pathologic phenomenon [2,3]. The incidence of anemia is reported to be around 30% in hypothyroidism; in contrast, pancytopenia is very rare in hypothyroidism [2].…”

Section: Discussionmentioning

confidence: 99%

A Unique Case of Hypothyroidism Causing Pancytopenia With Literature Review

Khan¹,

Oo²,

Htet³

et al. 2022

Cureus

View full text Add to dashboard Cite

Severe endocrinopathies can lead to pancytopenia. Hypothyroidism can affect any organ system including hematopoietic, resulting mainly in a normochromic normocytic anemia. Rarely, in severe hypothyroidism, all hematopoietic cell lines can be affected, resulting in pancytopenia. We, hereby, would like to discuss a case of hypothyroidism with worsening pancytopenia, which gradually improved after repletion with levothyroxine. Although pancytopenia is not a common feature of hypothyroidism, this case highlights the importance of hypothyroidism being considered as one of the differentials.

show abstract

Section: Discussionmentioning

confidence: 99%

A Unique Case of Hypothyroidism Causing Pancytopenia With Literature Review

Khan¹,

Oo²,

Htet³

et al. 2022

Cureus

View full text Add to dashboard Cite

show abstract

“…The pathogenesis of anemia in hypothyroidism may be related to decreased oxygen requirement due to a decrease in the basal metabolic rate [6]. Pancytopenia due to marrow hypoplasia has been hypothesized and reported in patients with myxedema coma but does not seem to be commonplace [6, 8]. If it occurs in uncomplicated hypothyroidism, anemia is characteristically normochromic and normocytic, less common is macrocytic or microcytic [6].…”

Section: Discussionmentioning

confidence: 99%

“…Pancytopenia due to marrow hypoplasia has been hypothesized and reported in patients with myxedema coma but does not seem to be commonplace [6, 8]. If it occurs in uncomplicated hypothyroidism, anemia is characteristically normochromic and normocytic, less common is macrocytic or microcytic [6]. Some sources report the incidence of anemia in uncomplicated hypothyroidism to be slightly less than 30% [6].…”

Section: Discussionmentioning

confidence: 99%

“…If it occurs in uncomplicated hypothyroidism, anemia is characteristically normochromic and normocytic, less common is macrocytic or microcytic [6]. Some sources report the incidence of anemia in uncomplicated hypothyroidism to be slightly less than 30% [6]. Patients with hypothyroidism are known to have reduced levels of erythropoietin, with one theory being due to reduced renal perfusion [9].…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Myxedema Coma Complicated by Pancytopenia

Mupamombe

Reyes

Laskar

et al. 2019

Case Reports in Medicine

View full text Add to dashboard Cite

show abstract

“…The exact pathogenesis of anaemia secondary to hypothyroidism is not precisely explained but appears to reflect an adaptation to decreased tissue oxygen requirements resulting from a decrease in the basal metabolic rate. Hypothyroid individuals with anaemia and normal serum iron, B12, and folate levels, have an increase in haemoglobin soon after thyroid hormone replacement [4].…”

Section: Discussionmentioning

confidence: 99%

Pancytopenia secondary to hypothyroidism in a 13-year-old male child

Gkampeta¹,

Stamou²,

Kotsa³

et al. 2019

Med Clin Arch

View full text Add to dashboard Cite

Thyroid hormones have a crucial role in erythropoiesis and metabolism. They enhance erythropoiesis through hyper proliferation of immature erythroid progenitors and increase secretion of erythropoietin by inducing erythropoietin gene expression. Thyroid dysfunction has various effects on blood cells such as anaemia, erythrocytosis leukopenia, thrombocytopenia, and in rare cases pancytopenia. The exact pathogenesis of anaemia secondary to hypothyroidism is not precisely explained but appears to reflect an adaptation to decreased tissue oxygen requirements resulting from a decrease in the basal metabolic rate. In reviewing the literature, there have been few previously reported cases of hematological abnormalities due to hypothyroidism, all of them concerning adults. In this article, we describe a rare case of pancytopenia secondary to hypothyroidism in a 13-year-old male child and its partial reversal after thyroid hormone replacement. Hypothyroidism should be considered in patients with unexplained pancytopenia. Further studies are needed to determine the exact underlying disease mechanism.

show abstract

Pancytopenia and nephrotic syndrome related to autoimmune hypothyroidism

Cited by 7 publications

References 12 publications

A Unique Case of Hypothyroidism Causing Pancytopenia With Literature Review

A Unique Case of Hypothyroidism Causing Pancytopenia With Literature Review

Myxedema Coma Complicated by Pancytopenia

Pancytopenia secondary to hypothyroidism in a 13-year-old male child

Contact Info

Product

Resources

About