Pancreatitis in childhood

Sibert, Jonathan Richard

doi:10.1136/pgmj.55.641.171

Cited by 11 publications

(12 citation statements)

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“…Only one previous retrospective study has been conducted in the UK, but it was primarily designed to examine the aetiology, complications and outcomes of pancreatitis in children. It also estimated the incidence in only two regions 8 . Although the previous study included all cases of pancreatitis and children up to age 16 years, our incidence rate is double that estimated in Wales (0.4/100,000/year) and three-fold higher than Newcastle (0.25/100,000/year).…”

Section: Discussionmentioning

confidence: 99%

“…Although the previous study included all cases of pancreatitis and children up to age 16 years, our incidence rate is double that estimated in Wales (0.4/100,000/year) and three-fold higher than Newcastle (0.25/100,000/year). 8 This apparent increase in the UK incidence might be due to an increase in clinical awareness or to the change in its clinical associations, which was reflected by an increase in the proportion of some previously known associations, such as drugs, and the appearance of new associations not previously reported, such as organic acidaemias.…”

Section: Discussionmentioning

confidence: 99%

“…Despite recent advances in diagnostic techniques, including pancreatico-biliary imaging and genetic testing, we found a high proportion of idiopathic AP in UK children although this was within previously reported national ranges of 25-56%. 8,12,13 Idiopathic AP seems to be more common in children. It has been reported globally in a wide range of proportions in children, from 15 to 36% of total cases.…”

Section: Discussionmentioning

confidence: 99%

“…Sibert conducted a retrospective review of all pancreatitis cases (acute and chronic) admitted to hospital in the Newcastle area and Wales between 1968 and 1975 and estimated the annual rate of diagnosis of pancreatitis in children under 16 years at approximately 1/400,000 in Newcastle and 1/250,000 in Wales. 8 Until now, no national population-based study has been conducted, either prospectively or retrospectively, to investigate the frequency of this condition in children, in the UK or elsewhere.…”

Section: Introductionmentioning

confidence: 99%

“…2,11 Trauma and mumps were the commonest associations reported in the UK in the 1970/80's. 8,12,13 However, there has been no effort to re-examine the associated agents of this disease in the UK in the last three decades. The last study conducted within the UK was performed in Scotland in the 1990s on retrospective data from 1978-1992, where mumps (39%) and trauma (14%) were the most frequent associations.…”

Section: Introductionmentioning

confidence: 99%

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Incidence and Clinical Associations of Childhood Acute Pancreatitis

et al. 2016

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General rightsThis document is made available in accordance with publisher policies. Please cite only the published version using the reference above. Full terms of use are available: http://www.bristol.ac.uk/pure/about/ebr-terms Financial Disclosure: The authors have no financial relationships relevant to this article to disclose. Conflict of Interest:The authors have no conflicts of interest relevant to this article to disclose. What's Known on This Subject: Acute pancreatitis in childhood is a relatively rare but potentially serious condition. In the past, trauma and mumps have been the commonest associations. No study has ever estimated incidence within a childhood population on a prospective basis. AbbreviationsWhat This Study Adds: Acute pancreatitis has a childhood incidence in the UK of 0.78 per 100,000/year (95%CI 0.62-0.96). Gallstones and drug therapy are now the most commonly identified associations whilst mumps and trauma are identified rarely. Children of Pakistani heritage are disproportionately affected. Contributors' Statements:Abdalmonem Majbar: Dr Majbar helped with designing the data collection instruments, collected the data, conducted all analyses, drafted the initial manuscript, and approved the final manuscript as submitted.Eleri Cusick and Paul Johnson: Ms Cusick and Professor Johnson contributed to study conceptualization and design, took part in data interpretation, critically reviewed the manuscript, and approved the final manuscript as submitted.Richard Lynn: Mr Lynn contributed to study conceptualization and design, critically reviewed the manuscript, and approved the final manuscript as submitted.Linda Hunt: Dr Hunt supported and contributed to the statistical analysis, critically reviewed the manuscript, and approved the final manuscript as submitted.Julian Shield: Professor Shield conceptualized and designed the study, supervised and assisted data collection and analyses, critically reviewed the manuscript, and approved the final manuscript as submitted.All authors approved the final manuscript as submitted and agree to be accountable for all aspects of the work. Results: 94 cases (48 boys) fulfilled the diagnostic criteria. The median age at diagnosis was 11.2 years (range 1.3-14.9). White children accounted for 61% of the cases compared to 28% from Asian and 5% from African ethnicities. Pakistani children accounted for 18 of 26 (69%) Asian patients and 19% of the total cohort. The incidence of AP in children in the UK was 0.78 per 100,000/year (95%CI 0.62-0.96). The incidence in Pakistani children (4.55; 95%CI 2.60-7.39) was 7-fold greater than White children (0.63; 95%CI 0.47-0.83). Of the 94 cases: 35 (37%) were idiopathic or associated with drugs 18 (19%), gallstones 12 (13%), hereditary 7 (7%), organic acidaemias 7 (7%), anatomical anomalies 5 (5%), viral infections 3 (3%), systemic diseases 2 (2%) and trauma 1 (1%). The most common drug associations were asparaginase (28%), azathioprine (17%) and sodium valproate (17%). Conclusions:Whilst still relatively uncommon in the U...

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Incidence and Clinical Associations of Childhood Acute Pancreatitis

et al. 2016

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An intrapapillary pancreatic duct diverticulum: A rare but surgically correctable cause of juvenile pancreatitis

Hatfield

Dent

Marks

1982

British Journal of Surgery

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An 1 I-year-old girl presented with a 6-year history of abdominal pain. The attacks of 3-4 hours' duration started in the epigastrium, radiated to the back and were relieved by leaning forward. There was no history of rigors or jaundice. As she lived on a remote farm, medical attention was often delayed, and examination and blood tests between attacks were normal, including a barium meal, oral cholecystogram and GTT. On one occasion, on the day after an acute attack, the serum amylase was elevated, so she was referred for further investigation.She was a plump, well-nourished girl with no abnormal physical findings. A11 routine haematological and biochemical screening tests were normal. The serum amylase was 155 u/l (normal range 70-300); GTT normal; 3 day faecal fat 10.5 mmol/d (normal range 0-19). Serum lipid profile and serum and urinary amino profile were normal. Straight abdominal X-ray was normal, as was an ultrasound scan.On endoscopy, the second part of the duodenum was normal but the papilla of Vater was enlarged with a bulge above the papillary orifice. The pancreatogram demonstrated a small diverticulum arising superiorly from the origin of the pancreatic duct within the papilla (Fig. 1). There was slight irregularity of the side ducts and main duct in the distal body and tail of the pancreas compatible with minimal pancreatitis (Fig. 2). The biliary system was normal and drained via a separate orifice.

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Chronic Relapsing Pancreatitis in Childhood Caused by Pancreaticobiliary Ductal Anomaly

Karp,

Jewett,

Cooney

1983

J. pediatr. gastroenterol. nutr.

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SummaryChronic relapsing pancreatitis is a rare childhood disease. Although various obstructive phenomena have been implicated in its etiology, few reports have described the role played by anomalies of the pancreaticobiliary ductal system. Recently, a patient with a complex anomalous ductal communication was treated by us for chronic relapsing pancreatitis. This particular anomaly, and its clinical presentation, has not previously appeared in the literature. The problems associated with the diagnosis and surgical management of this patient have prompted this report.

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Pancreatitis in childhood

Cited by 11 publications

References 25 publications

Incidence and Clinical Associations of Childhood Acute Pancreatitis

Incidence and Clinical Associations of Childhood Acute Pancreatitis

An intrapapillary pancreatic duct diverticulum: A rare but surgically correctable cause of juvenile pancreatitis

Chronic Relapsing Pancreatitis in Childhood Caused by Pancreaticobiliary Ductal Anomaly

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