Pancreatitis Associated with Serotonin-Dopamine Antagonists

Nishawala, Melissa A.; Callaghan, Marian; Malatack, J. Jeffrey; Moughan, Beth; Ambrosini, Paul J.; Price, Bernadette; Elia, Josephine

doi:10.1089/cap.1997.7.211

Journal of Child and Adolescent Psychopharmacology

1997

DOI: 10.1089/cap.1997.7.211

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Pancreatitis Associated with Serotonin-Dopamine Antagonists

Melissa A. Nishawala¹,

Marian Callaghan²,

J. Jeffrey Malatack³

et al.

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Cited by 4 publications

(1 citation statement)

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“…[6][7][8][9][10] Reports of pancreatitis occurring in association with the atypical antipsychotic clozapine were published in 1992 11,12 and were followed by reports of pancreatitis associated with olanzapine. 13 Some of these cases were accompanied by varying degrees of new-onset hyperglycemia, another adverse event associated with the atypical antipsychotic agents. 14,15 Before the introduction of the atypical agents, antipsychotics seldom were associated with pancreatitis.…”

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Pancreatitis Associated with Atypical Antipsychotics: From the Food and Drug Administration's MedWatch Surveillance System and Published Reports

et al. 2003

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The number of reports involving the three atypical antipsychotic agents and the relative paucity of reports involving haloperidol, despite its more extensive patient exposure, suggest that atypical antipsychotics may precipitate pancreatitis. However, the risk may not be the same with all agents; pancreatitis was reported most frequently with clozapine, followed by olanzapine, and then risperidone. The temporal relationship of the onset of pancreatitis with the start of drug therapy further supports a cause-and-effect relationship.

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Pancreatitis Associated with Atypical Antipsychotics: From the Food and Drug Administration's MedWatch Surveillance System and Published Reports

et al. 2003

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Second-Generation Antipsychotic Medications in Children and Adolescents

Cheng-Shannon

McGough

Pataki

et al. 2004

Journal of Child and Adolescent Psychopharmacology

135

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Although the evidence base for pediatric use of second-generation antipsychotics is expanding, the majority of available studies are anecdotal, or short-term, openlabel trials. Reports suggest that these compounds are effective for a variety of psychiatric disorders in children and adolescents, but additional double-blind, controlled studies are required to establish definitive efficacy. Although these medications appear to be well tolerated in short-term studies, long-term follow-up investigations and ongoing clinical monitoring are necessary to confirm their safety in this age group.

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Fatal Pancreatitis Associated with Valproic Acid

2002

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Pancreatitis Associated with Serotonin-Dopamine Antagonists

Cited by 4 publications

References 2 publications

Pancreatitis Associated with Atypical Antipsychotics: From the Food and Drug Administration's MedWatch Surveillance System and Published Reports

Pancreatitis Associated with Atypical Antipsychotics: From the Food and Drug Administration's MedWatch Surveillance System and Published Reports

Second-Generation Antipsychotic Medications in Children and Adolescents

Fatal Pancreatitis Associated with Valproic Acid

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