Pancreatitis and anomalous union of the pancreaticobiliary ductal system in childhood

Mori, Kazuhiro; Nagakawa, Takukazu; Ohta, Tetsuo; Nakano, Tatsuo; Kayahara, Masato; Akiyama, Takayoshi; Kanno, Masahiro; Ueno, Koichi; Konishi, Ichirou; Izumi, Ryouhei; Konishi, Kohji; Miyazaki, Itsuo

doi:10.1016/s0022-3468(05)80358-6

Cited by 30 publications

(24 citation statements)

References 4 publications

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“…4 Also, while pancreaticobiliary maljunction is rarely reported in Chile or the United States, it is an important GBCA risk factor in Japan. 6,13,35 …”

Section: Discussionmentioning

confidence: 99%

Regional Differences in Gallbladder Cancer Pathogenesis: Insights from a Comparison of Cell Cycle-Regulatory, PI3K, and Pro-Angiogenic Protein Expression

et al. 2012

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Background The variable incidence of gallbladder cancer (GBCA) suggests regional pathogenetic differences. This study compares cell cycle-regulatory, angiogenesis-related, and PI3K pathway protein expression in GBCAs from three continents. Methods Immunohistochemical expression of several proteins was assessed, correlated with clinicopathologic variables, and compared among centers from Chile (Fundación Arturo López Pérez [FALP]), Japan (Yokohama City University [YCU]), and the United States (Memorial Sloan-Kettering Cancer Center [MSKCC]). Hierarchical clustering was used to partition the data based on protein-expression and treatment center. Results Tissue from 117 patients (MSKCC = 76; FALP = 22; YCU = 19) was analyzed. Mdm2 overexpression was seen only at MSKCC (p < 0.0001). Absence of p21 (p = 0.03) and VEGFR2 (p = 0.018) were more common and p27 expression was less frequent (p = 0.047) in tumors from YCU. Ki-67 labeling index in YCU tumors (median = 10) was two-thirds lower than at other centers. On hierarchical clustering analysis, all YCU patients (p = 0.017) and those with early tumors (p = 0.017) clustered separately from MSKCC. Median disease-specific survival after curative intent (R0) resection was 27 months and was similar among centers (p = 0.9). Median disease-specific survival of patients with early tumors was 28.4 months and was higher at YCU (not reached, p = 0.06). Conclusions Cell cycle-regulatory protein expression patterns of YCU tumors differed from those treated at FALP and MSKCC. The differential clustering of protein expression and survival in patients with early tumors suggest regional differences in pathogenesis and disease biology.

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“…4 Also, while pancreaticobiliary maljunction is rarely reported in Chile or the United States, it is an important GBCA risk factor in Japan. 6,13,35 …”

Section: Discussionmentioning

confidence: 99%

Regional Differences in Gallbladder Cancer Pathogenesis: Insights from a Comparison of Cell Cycle-Regulatory, PI3K, and Pro-Angiogenic Protein Expression

et al. 2012

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“…An anomalous pancreaticobiliary union has been observed in most children with choledochal cysts and recurrent pancreatitis [41,51,52]. In this subgroup of patients, SOD has been demonstrated, suggesting that this motor abnormality might be related to the development of recurrent pancreatitis [41].…”

Section: Choledochal Cyst and Anomalous Pancreaticobiliary Unionmentioning

confidence: 78%

Sphincter of oddi dysfunction in children

Guelrud

Rodriguez²

2006

Curr Gastroenterol Rep

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Sphincter of Oddi dysfunction (SOD) is a clinical entity caused by a primary motility alteration of either the biliary or the pancreatic sphincter. SOD is a rare condition that has been scarcely reported in children. Most of the reported literature has been in children with idiopathic recurrent pancreatitis. These children are treated endoscopically by dual sphincterotomy of the pancreatic and common duct sphincters. However, the safety and efficacy of sphincter of Oddi manometry and sphincterotomy in the pediatric population await further study.

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“…An anomalous pancreaticobiliary union has been observed in most children with choledochal cysts and recurrent pancreatitis (Figure 23.13) [31,57]. In this subgroup of patients, SOD has been demonstrated, suggesting that this motor abnormality might be related to the development of recurrent pancreatitis [58].…”

Section: Choledochal Cyst and Anomalous Pancreaticobiliary Unionmentioning

confidence: 87%