Pancreatitis aguda inducida por doxiciclina

Justo, Linette Achécar; Fernández, M.; Reinoso, Javier Cobo; Olmos, L.

doi:10.1016/j.medcli.2009.04.002

Cited by 11 publications

(3 citation statements)

References 6 publications

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“…However, there are only four reports of DIP following doxycycline, either as a monotherapy or in combination therapy, shown in Table 1 . [ 2 3 4 ] To our surprise, all four were female patients. However, reports of doxycycline as the sole etiology of DIP, as in our case, are extremely rare.…”

Section: Discussionmentioning

confidence: 95%

“…The literature is scant on the association of DIP with doxycycline. [ 2 3 4 ] We present this unusual case in which DIP symptoms were demonstrated following the second day of initiation of doxycycline treatment. In our patient, diagnosis of DIP was made by exclusion of all common etiologies of acute pancreatitis such as alcohol, gallstones, hypercalcemia, hypertriglyceridemia, infection, trauma, or medical procedures such as endoscopic retrograde cholangiopancreatography (ERCP).…”

Section: Introductionmentioning

confidence: 99%

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Drug-induced pancreatitis: A rare manifestation of doxycycline administration

et al. 2016

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Context:Drug-induced pancreatitis (DIP) is rare, but as there are no systematic data on it, the true incidence is not known. Although numerous and varied drugs have been associated with DIP, the clinical evidence on doxycycline-induced pancreatitis is sparse.Case Report:We present the case of a 58-year-old female who presented with complaints of nausea and severe epigastric pain. Her medications included doxycycline which she had been on for only 2 days. Computed tomography of her abdomen showed mild enlargement of body of the pancreas with peripancreatic fatty infiltration, along with lipase level suggestive of acute pancreatitis. In the absence of classical risk factors for acute pancreatitis, a diagnosis of DIP secondary to doxycycline therapy was made. Immediate withdrawal of the drug was accompanied by relief of symptoms and resolution of pancreatitis.Conclusion:This report implicates doxycycline as an etiological factor for acute pancreatitis. Knowledge regarding doxycycline related pancreatitis is of paramount importance in order to diagnose cases early and institute effective treatment in patients who are undergoing therapy with this drug.

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Section: Discussionmentioning

confidence: 95%

Section: Introductionmentioning

confidence: 99%

Drug-induced pancreatitis: A rare manifestation of doxycycline administration

et al. 2016

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“…In three of the cases mentioned above, there was no consistent latency between cases and no rechallenge and thus this drug was included in class III in the Simons-Linares classification. In contrast, Wolfe et al included four different cases from the above-mentioned review, all of which had no positive rechallenge and in which other causes of pancreatitis have been excluded; therefore, the drug was classified as Ic [11,44,46,[49][50][51][52][53][54][55].…”

Section: Tetracyclinesmentioning

confidence: 99%

Drug-Induced Acute Pancreatitis in Adults: Focus on Antimicrobial and Antiviral Drugs, a Narrative Review

Del Gaudio,

Covello,

Di Vincenzo

et al. 2023

Antibiotics

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Acute pancreatitis (AP) is an acute inflammation of the pancreas caused by the activation of digestive enzymes in the pancreatic tissue. The main causes of AP are cholelithiasis and alcohol abuse; less commonly, it can be caused by drugs, with a prevalence of up to 5%. Causal associations between drugs and pancreatitis are largely based on case reports or case series with limited evidence. We reviewed the available data on drug-induced AP, focusing on antimicrobial drugs and antivirals, and discussed the current evidence in relation to the classification systems available in the literature. We found 51 suspected associations between antimicrobial and antiviral drugs and AP. The drugs with the most evidence of correlation are didanosine, protease inhibitors, and metronidazole. In addition, other drugs have been described in case reports demonstrating positive rechallenge. However, there are major differences between the various classifications available, where the same drug being assigned to different probability classes. It is likely that the presence in multiple case reports of an association between acute pancreatitis and a drug should serve as a basis for conducting prospective randomized controlled trials to improve the quality of the evidence.

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Anthelmintics in Dermatology

Worswick¹,

Dreyer²

2018

Biologic and Systemic Agents in Dermatology

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Pancreatitis aguda inducida por doxiciclina

Cited by 11 publications

References 6 publications

Drug-induced pancreatitis: A rare manifestation of doxycycline administration

Drug-induced pancreatitis: A rare manifestation of doxycycline administration

Drug-Induced Acute Pancreatitis in Adults: Focus on Antimicrobial and Antiviral Drugs, a Narrative Review

Anthelmintics in Dermatology

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