Pancreatic schwannoma: Report of a case

Okuma, Toshitada; Hirota, Masahiko; Nitta, Hidetoshi; Saito, Seiya; Yagi, Takeshi; Ida, Satoshi; Okamura, Shigeki; Chikamoto, Akira; Iyama, Ken Ichi; Takahashi, Hiroshi; Kanemitsu, Keiichiro; Baba, Hideo

doi:10.1007/s00595-007-3611-8

Cited by 19 publications

(12 citation statements)

References 25 publications

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“…(See Table 1. [31][32][33][34][35][36][37][38][39][40][41] In conclusion, we present a case of an 8-cm pancreatic schwannoma characterized by cystic degeneration, which was asymptomatic and was diagnosed incidentally while an examination was performed for an ovarian teratoma. Although pancreatic schwannoma is a rare benign disease, it should be included in the list of differential diagnoses of pancreatic mass with cystic changes.…”

Section: Discussionmentioning

confidence: 99%

Pancreatic Schwannoma: Literature Review

Gupta

Subhas

Mittal

et al. 2009

Journal of Surgical Education

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Section: Discussionmentioning

confidence: 99%

Pancreatic Schwannoma: Literature Review

Gupta

Subhas

Mittal

et al. 2009

Journal of Surgical Education

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“…Schwannomas are benign mesenchymal neoplasms composed of well differentiated Schwann cells. Pancreatic schwannomas are rare benign mesenchymal neoplasms, and have been mainly described as case reports in the English literature 2,15–26 . The majority of the reported pancreatic schwannomas show a classic morphology with various proportions of Antoni A and Antoni B tissue 2,15–26 and rarely large pancreatic schwannomas undergoing degenerative cystic changes 27–30 have been described.…”

Section: Discussionmentioning

confidence: 99%

Microcystic/reticular schwannoma of the pancreas: A potential diagnostic pitfall

Liegl¹,

Bodó²,

Martin³

et al. 2010

Pathology International

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Schwannomas occurring in the pancreatic head are rare benign non-recurring mesenchymal neoplasms and are reported to show classic morphologic features. Herein we report a case of a 62 year old male presenting with a 5 cm mass in the pancreatic head encasing the portal vein and the truncus coeliacus. Preoperative fine needle aspiration revealed malignant tumour cells consistent with a moderately differentiated adenocarcinoma. A Whipple surgery was performed after palliative chemotherapy. Histological evaluation revealed a multinodular unencapsulated tumour with focal infiltration into pancreas parenchyma and a striking microcystic/reticular growth pattern. Anastomosing and intersecting strands of spindle cells with eosinophilic cytoplasm set in a myxoid partly collagenous stroma were observed. The tumour cell nuclei were round oval and tapered and showed inconspicuous small nucleoli. Degenerative nuclear atypia was seen. Mitotic activity was sparse (1/50 HPF). Pleomorphism or necrosis was absent. The tumour cells showed strong nuclear and cytoplasmic positivity for S-100 protein, and focal positivity for glial fibrillary acidic protein. The diagnosis of a microcystic/reticular schwannoma was made. The awareness of and, to some extent, the knowledge about this rare tumour are needed to achieve the correct diagnosis and to avoid confusion, especially with malignant pancreatic neoplasms.

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“…In the present case, we performed a spleen-preserving distal pancreatectomy for the mass that was found in the neck and body of the pancreas. To date, spleen-preserving distal pancreatectomy has only been reported in one other case of pancreatic schwannoma[38]; here we describe the second reported case. Compared with the traditional distal pancreatectomy and splenectomy for tumors in the body or tail of the pancreas, spleen-preserving distal pancreatectomy can not only offer complete resection of the tumor but also preserve the spleen.…”

Section: Discussionmentioning

confidence: 90%

Successful treatment of a pancreatic schwannoma by spleen-preserving distal pancreatectomy

et al. 2017

WJG

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Schwannomas are neurogenic tumors that arise from the neural sheaths of peripheral nerves. These tumors can be located in any area of the human body; the most common locations are the head, neck, trunk and extremities. Pancreatic schwannomas are very rare. Over the past 40 years, only 67 cases of pancreatic schwannomas have been reported in the English literature. Here we present a case of pancreatic schwannoma in a 62-year-old male. The tumor was revealed by ultrasound and computed tomography in the neck and body of the pancreas. An accurate diagnosis was difficult to obtain preoperatively. The patient consented to the performance of a laparotomy, and the mass was found in the neck and body of the pancreas and successfully treated using a spleen-preserving distal pancreatectomy with splenic artery and vein preservation. The procedure has only been reported in one other case of pancreatic schwannoma; here we present the second reported case. Macroscopically, the tumor was well circumscribed, gray-white in color and 3.3 cm × 2.8 cm in size. Microscopically, the tumor cells were spindle-shaped and had a palisading arrangement with no atypia, which are results compatible with a benign tumor. Both hypercellular and hypocellular areas were visible. Immunohistochemically, the tumor cells were strongly positive for S-100 protein. The tumor was definitively diagnosed as a schwannoma of the pancreatic neck and body. The patient was followed for 72 mo and has been doing well without any complications.

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Pancreatic schwannoma: Report of a case

Cited by 19 publications

References 25 publications

Pancreatic Schwannoma: Literature Review

Pancreatic Schwannoma: Literature Review

Microcystic/reticular schwannoma of the pancreas: A potential diagnostic pitfall

Successful treatment of a pancreatic schwannoma by spleen-preserving distal pancreatectomy

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