Pancreatic polypeptide stimulates mouse gastric motor activity through peripheral neural mechanisms

Amato, Antonella; Baldassano, Sara; Caldara, Gaetano Felice; Mulè, Flavia

doi:10.1111/nmo.12901

Cited by 3 publications

(1 citation statement)

References 50 publications

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“…They can increase cFOS activity in enteric neurons and exert powerful inhibitory effects on myenteric neurons of the descending colon ( 33 , 36 ). In proximal part of the GI tract, exogenous PP stimulates mouse gastric motor activity, by activating gastric enteric excitatory neurons releasing acetylcholine (Ach) and tachykinins ( 35 ) (Table 1 ).…”

Section: Peptides Modulating Ens Neuronsmentioning

confidence: 99%

Impact of Intestinal Peptides on the Enteric Nervous System: Novel Approaches to Control Glucose Metabolism and Food Intake

2018

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The gut is one of the most important sources of bioactive peptides in the body. In addition to their direct actions in the brain and/or peripheral tissues, the intestinal peptides can also have an impact on enteric nervous neurons. By modifying the endogenousproduction of these peptides, one may expect modify the “local” physiology such as glucose absorption, but also could have a “global” action via the gut–brain axis. Due to the various origins of gut peptides (i.e., nutrients, intestinal wall, gut microbiota) and the heterogeneity of enteric neurons population, the potential physiological parameters control by the interaction between the two partners are multiple. In this review, we will exclusively focus on the role of enteric nervous system as a potential target of gut peptides to control glucose metabolism and food intake. Potential therapeutic strategies based on per os administration of gut peptides to treat type 2 diabetes will be described.

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Section: Peptides Modulating Ens Neuronsmentioning

confidence: 99%

Impact of Intestinal Peptides on the Enteric Nervous System: Novel Approaches to Control Glucose Metabolism and Food Intake

2018

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Identification of peptides from Corneum Galli Gigeri Endothelium and inhibiting H2O2-induced gastric mucosa associated with the Rho signaling pathway

Guo,

Zhang,

Chen

et al. 2024

Food Bioscience

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Alterations in Enteroendocrine Hormones After Total Pancreatectomy With Islet Autotransplantation

et al. 2020

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Objective When total pancreatectomy with islet autotransplantation (TPIAT) is performed for chronic pancreatitis, the pancreas and most of the duodenum are removed, with Roux-en-Y reconstruction of the gastrointestinal tract. Enteroendocrine cells in the intestines and pancreas secrete hormones coordinating digestion and motility, but anatomic reconstruction alters transit of nutrients to these cells. We hypothesized that TPIAT leads to changes in enteroendocrine hormones. Methods Glucagon-like peptide 1 (GLP-1), peptide YY (PYY), and pancreatic polypeptide (PP) were measured from mixed-meal tolerance tests of 34 clinical trial participants before and 18 months after TPIAT. Area under the curve of GLP-1 and PYY-stimulated responses were calculated by trapezoidal method, and the PP response was measured as the stimulated max minus baseline (ΔPP). Results Area under the curve of GLP-1 and PYY increased significantly after TPIAT (GLP-1 average +553.1 pg/mL per minute, P = 0.004; PYY average +4647.9 pg/mL per minute, P = 0.02). ΔPP trended toward lower after TPIAT (average, −52.2 pg/mL, P = 0.06). Conclusions In this novel study of enteroendocrine hormones in TPIAT patients, stimulated levels of GLP-1 and PYY were significantly higher after versus before TPIAT. ΔPP was lower after TPIAT, but not significantly. These hormone changes have potential clinical implications that warrant further research.

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Pancreatic polypeptide stimulates mouse gastric motor activity through peripheral neural mechanisms

Abstract: The present findings demonstrate that exogenous PP stimulates mouse gastric motor activity, by acting directly on the stomach. This effect appears due to the activation of enteric excitatory neurons releasing acetylcholine and tachykinins.

Cited by 3 publications

References 50 publications

Impact of Intestinal Peptides on the Enteric Nervous System: Novel Approaches to Control Glucose Metabolism and Food Intake

Impact of Intestinal Peptides on the Enteric Nervous System: Novel Approaches to Control Glucose Metabolism and Food Intake

Identification of peptides from Corneum Galli Gigeri Endothelium and inhibiting H2O2-induced gastric mucosa associated with the Rho signaling pathway

Alterations in Enteroendocrine Hormones After Total Pancreatectomy With Islet Autotransplantation

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