Pancreatic Panniculitis in a 4‐year‐old Child with Nephrotic Syndrome

Suwattee, F.R.C.P.C. Pitiporn; Cham, Peter M. H.; Pope, F.R.C.P.C. Elena; Ho, Fcs

doi:10.1111/j.1525-1470.2007.00561.x

Cited by 25 publications

(31 citation statements)

References 3 publications

(4 reference statements)

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“…It is speculated that trypsin and phospholipase may erode the blood vessel endothelium and increase the vasopermeability, thereby allowing lipase to enter into the subcutaneous fat and hydrolyze triglycerides to form free fatty acids 6 . However, most cases of pancreatitis have high levels of serum amylase and/or lipase without subcutaneous fat necrosis.…”

Section: Discussionmentioning

confidence: 99%

“…Anucleated adipocytes with a thickened shadowy wall and granular basophilic cytoplasm, and these are called 'ghost-like' cells, can be seen in the affected fat lobules. Surrounding the foci of fat necrosis is an inflammatory infiltrate consisting of neutrophils, lymphocytes, macrophages and multinucleated giant cells 6 . These histologic changes are not static.…”

Section: Discussionmentioning

confidence: 99%

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Pancreatic Panniculitis Associated with Acinar Cell Carcinoma of the Pancreas: A Case Report

et al. 2011

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Pancreatic panniculitis is a rare type of disorder associated with pancreatic diseases. We describe here a case of 54-year-old man who was admitted to the Department of Dermatology with the diagnosis of erythema nodosum. The patient presented with a 9-month history of painful erythematous nodules on the extremities, joint pain and swelling, and weight loss. A highly elevated level of pancreatic lipase was found on the laboratory examinations. The biopsy specimens from the skin lesions showed subcutaneous fat necrosis. Abdominal computed tomography (CT) revealed a large mass with central necrosis in the body and tail of the pancreas. Distal pancreatectomy, splenectomy and partial transverse colectomy were successfully performed on day 17 of the hospitalization. The histopathologic findings supported the diagnosis of acinar cell carcinoma of the pancreas (ACCP). Postoperatively, the level of serum lipase returned to normal, and the skin lesions and joint manifestations gradually regressed. However, the swelling did not significantly resolve in the left knee. In view of the non-specific clinical presentation of this disease, clinicians should be alert and have a high index of suspicion for pancreatic panniculitis.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Pancreatic Panniculitis Associated with Acinar Cell Carcinoma of the Pancreas: A Case Report

et al. 2011

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“…There are also sporadic case reports in which the condition occured during the course of other diseases such as pancreatic pseudocysts, pancreatic fistulas, congenital anomalies of pancreas (pancreas divisum), HIV infection [1][2][3]. There are also solitary reports of patients with systemic lupus erythematosus [5], nephrotic syndrome [6], liver carcinoma [7], and adenocarcinoma of unknown origin [8]. Our case presented with the signs and symptoms of gastric adenocarcinoma and at the time of diagnosis the tumor had already spread to the whole abdomen and peritoneum.…”

Section: Discussionmentioning

confidence: 95%

Pancreatic panniculitis as the first manifestation of the pancreatic involvement during the course of a gastric adenocarcinoma

Beyazıt

Aydın²,

Demirkesen³

et al. 2010

Med Oncol

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Pancreatic panniculitis (PP) is a rare disease presenting during the course of pancreatic diseases such as acute and chronic pancreatitis, pancreatic carcinoma. There are also a few reports of PP associated with other carcinomas. We present a 69-year-old male patient of gastric carcinoma with PP. The literature is reviewed, clinical and histological features of the case are discussed. This is the first case of PP in a gastric carcinoma patient reported in literature. As a conclusion, PP can be the first manifestation of a pancreatic metastasis of any carcinoma.

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“…Prior to this, Suwattee et al have reported pancreatic panniculitis in 4 year old child with nephrotic syndrome. [17]…”

Section: Discussionmentioning

confidence: 99%

Pancreatic panniculitis in a child

Rao

Danturty

2010

Indian J Dermatol

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Pancreatic panniculitis is an uncommon cause of panniculitis. It is associated with acute or chronic pancreatic disease. 1½ year old boy was referred for erythematous tender nodules involving both legs and associated with abdominal distention, fever, and vomiting. Dermatological examination revealed multiple erythematous tender nodules distributed over front and back of legs. Blood chemistry showed raised serum amylase (430 IU/ 1). Ultrasonography showed a pseudopancreatic cyst. Multislice CT scan was suggestive of a pseudopancreatic cyst. A skin biopsy showed typical features of pancreatic panniculitis which included lobular panniculitis with lipocyte degeneration with few Ghost cells.

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Pancreatic Panniculitis in a 4‐year‐old Child with Nephrotic Syndrome

Abstract: Pancreatic panniculitis is an uncommon disorder with a distinctive histopathology. We report the youngest patient with pancreatic panniculitis caused by hypertriglyceridemia in association with nephrotic syndrome.

Cited by 25 publications

References 3 publications

Pancreatic Panniculitis Associated with Acinar Cell Carcinoma of the Pancreas: A Case Report

Pancreatic Panniculitis Associated with Acinar Cell Carcinoma of the Pancreas: A Case Report

Pancreatic panniculitis as the first manifestation of the pancreatic involvement during the course of a gastric adenocarcinoma

Pancreatic panniculitis in a child

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