“Pancreatic Panniculitis”

Sotoude, Hamed; Mozafari, Rambod; Mohebbi, Zahra; Mirfazaelian, Hadi

doi:10.1016/j.ajem.2014.01.022

Cited by 4 publications

(2 citation statements)

References 4 publications

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“… 73 f ACC of the liver death ten weeks after first skin lesion 2 [ 53 ] 55 m metastatic pancreatic NEC n.r. 3 [ 54 ] 38 m acute pancreatitis resolution 4 [ 7 ] 63 m acute pancreatitis resolution 5 [ 55 ] 81 f hemosuccus pancreaticus death 19 weeks after first skin lesion 6 [ 56 ] 26 f acute pancreatitis resolution 7 [ 57 ] 27 f acute pancreatitis resolution 8 [ 58 ] 34 m chronic pancreatitis n.r. 9 [ 59 ] 63 f acute pancreatitis resolution 10 [ 60 ] 83 m pancreatic ACC resolution of skin lesions after surgery, death 34 months after first skin lesion 11 [ 60 ] 75 m Acute pancreatitis resolution 12 [ 60 ] 60 m Large pancreatic neoplasm n.r.…”

Section: Case Presentationmentioning

confidence: 99%

Pancreatic panniculitis in a patient with pancreatic-type acinar cell carcinoma of the liver – case report and review of literature

et al. 2016

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BackgroundPancreatic panniculitis is a rare condition, which has only been described in relation with pancreatic diseases up to now. It is characterized by necrotizing subcutaneous inflammation and is thought to be triggered by adipocyte necrosis due to systemic release of pancreatic enzymes with consecutive infiltration of neutrophils. We present the first case of a patient with pancreatic panniculitis caused by pancreatic-type primary acinar cell carcinoma (ACC) of the liver and without underlying pancreatic disease.Case presentationA 73-year old Caucasian female patient was referred to our department with painful cutaneous nodules persisting for eight weeks and with marked lipasemia (~15000 U/l; normal range <60 U/l). Four weeks prior, several liver lesions had been detected. Empiric treatment with steroids did not show any effect. A biopsy of the skin nodules revealed “pancreatic” panniculitis, while abdominal imaging with ultrasound, computed tomography and magnetic resonance imaging detected no abnormal pancreatic findings. Ultrasound-guided biopsy of the liver lesions showed infiltrates of an ACC. The patient died soon thereafter. Autopsy failed to reveal any other primary for the ACC, so that a pancreatic-type ACC of the liver was diagnosed by exclusion.One hundred thirty cases of pancreatic panniculitis published within the last 20 years are reviewed. ACC of the pancreas is the most common underlying neoplastic condition. Patients with associated neoplasm are significantly older, take longer to be diagnosed and have higher lipase levels than patients with underlying pancreatitis.Extrapancreatic pancreatic-type ACC is very rare, but shows the same biological features as ACC of the pancreas. It is believed to develop from metaplastic or ectopic pancreatic tissue. Up to now, no pancreatic panniculitis in extrapancreatic ACC has been described.ConclusionPancreatic panniculitis should always be included in the differential diagnosis of lipolytic panniculitic lesions. It can be regarded as a facultative paraneoplastic phenomenon.When suspected, a thorough work-up for identification of the underlying disease is mandatory and extrapancreatic lesions (e.g. liver) should also be considered. While administration of octreotide or steroids can sometimes alleviate symptoms, immediate treatment of the associated condition is the only effective management option.

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Section: Case Presentationmentioning

confidence: 99%

Pancreatic panniculitis in a patient with pancreatic-type acinar cell carcinoma of the liver – case report and review of literature

et al. 2016

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“…In the clinical setting, panniculitis is noticed as erythematous, ill-defined, and/or redbrown nodules [2] that generally affect the lower limbs and buttocks, rarely the trunk and upper extremities [3]. Only 9 cases have been described of pancreatic panniculitis on the trunk [3][4][5][6][7][8][9][10][11]. We encountered a unique case of subcutaneous nodules on the abdomen with latent IPMN.…”

Section: Discussionmentioning

confidence: 99%

A case report of pancreatic panniculitis due to acute pancreatitis with intraductal papillary mucinous neoplasm

et al. 2020

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Background: Pancreatic panniculitis is a rare skin manifestation in pancreatic disease patients that most frequently develops on the lower legs. We report the unique case of a 68-year-old man who suffered from pancreatic panniculitis on his trunk associated with acute pancreatitis due to an intraductal papillary mucinous neoplasm. Case presentation: A 68-year-old man complained of a 2-day history of a tender subcutaneous nodule on his trunk. Laboratory tests and abdominal contrast computed tomography were consistent with acute pancreatitis due to an intraductal papillary mucinous neoplasm. A skin biopsy of the nodule histologically displayed lobular panniculitis with characteristic "ghost cells", which indicated pancreatic panniculitis. Conclusions: In order to avoid a missed or delayed diagnosis, clinicians should bear in mind that pancreatic panniculitis can be the first manifestation of pancreatic disease when encountering subcutaneous nodules on the trunk.

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Cutaneous Signs of Internal Malignancy

Bach,

Pena-Robichaux

2024

Curr Geri Rep

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“Pancreatic Panniculitis”

Cited by 4 publications

References 4 publications

Pancreatic panniculitis in a patient with pancreatic-type acinar cell carcinoma of the liver – case report and review of literature

Pancreatic panniculitis in a patient with pancreatic-type acinar cell carcinoma of the liver – case report and review of literature

A case report of pancreatic panniculitis due to acute pancreatitis with intraductal papillary mucinous neoplasm

Cutaneous Signs of Internal Malignancy

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