Pancreatic neuroendocrine tumours

Ruíz-Tóvar, Jaime; Priego, Pablo; Martínez-Molina, Enrique; Morales, Vicente; Sanjuánbenito, Alfonso; Lobo, Eduardo

doi:10.1007/s12094-008-0238-1

Cited by 9 publications

(8 citation statements)

References 8 publications

(11 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Heterogeneity of the 16 retrospective studies was too high to pool all 22 studies, as depicted in Fig. 2 [29–44]. Overall PF rate grade B/C after tumor enucleation was 27 % (95 % CI 19–37 %), based on 8 studies with a total of 324 included patients [24, 25, 27, 28, 38, 40, 43] (see appendix Fig.…”

Section: Resultsmentioning

confidence: 99%

“…Overall PF rate after distal pancreatectomy was 14 % (95 % CI 10–19 %), based on 18 studies with a total of 383 included patients, as depicted in Fig. 3 [23, 24, 29–37, 39, 41–44, 45, 46]. The overall grade B/C PF rate after distal pancreatectomy was 8 % (95 % CI 2–35 %), based on 2 studies with a total of 74 included patients [24, 43] (see appendix Fig.…”

Section: Resultsmentioning

confidence: 99%

“…Overall pooled in‐hospital mortality rate after tumor enucleation was 3 % (95 % CI 2–5 %), based on 20 studies with a total amount of 624 patients [23–25, 28–40, 42, 44, 46] (see appendix Fig. 19).…”

Section: Resultsmentioning

confidence: 99%

See 2 more Smart Citations

Postoperative Complications, In‐Hospital Mortality and 5‐Year Survival After Surgical Resection for Patients with a Pancreatic Neuroendocrine Tumor: A Systematic Review

et al. 2015

View full text Add to dashboard Cite

Studies on postoperative complications and survival in patients with pancreatic neuroendocrine tumors (pNET) are sparse and randomized controlled trials are not available. We reviewed all studies on postoperative complications and survival after resection of pNET. A systematic search was performed in the Cochrane Central Register of Controlled Trials, MEDLINE and EMBASE from 2000–2013. Inclusion criteria were studies of resected pNET, which described postoperative complications separately for each surgical procedure and/or 5-year survival after resection. Prospective and retrospective studies were pooled separately and overall pooled if heterogeneity was below 75 %. The random-effect model was used. Overall, 2643 studies were identified and after full-text analysis 62 studies were included. Pancreatic fistula (PF) rate of the prospective studies after tumor enucleation was 45 %; PF-rates after distal pancreatectomy, pancreatoduodenectomy, or central pancreatectomy were, respectively, 14–14–58 %. Delayed gastric emptying rates were, respectively, 5–5–18–16 %. Postoperative hemorrhage rates were, respectively, 6–1–7–4 %. In-hospital mortality rates were, respectively, 3–4–6–4 %. The 5-year overall survival (OS) and disease-specific survival (DSS) of resected pNET without synchronous resected liver metastases were, respectively, 85–93 %. Heterogeneity between included studies on 5-year OS in patients with synchronous resected liver metastases was too high to pool all studies. The 5-year DSS in patients with liver metastases was 80 %. Morbidity after pancreatic resection for pNET was mainly caused by PF. Liver resection in patients with liver metastases seems to have a positive effect on DSS. To reduce heterogeneity, ISGPS criteria and uniform patient groups should be used in the analysis of postoperative outcome and survival.

show abstract

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

See 1 more Smart Citation

Postoperative Complications, In‐Hospital Mortality and 5‐Year Survival After Surgical Resection for Patients with a Pancreatic Neuroendocrine Tumor: A Systematic Review

et al. 2015

View full text Add to dashboard Cite

show abstract

“…[3] In the pediatric age group, they have an infrequent prevalence. [1] The youngest reported case was just under 2 years of age.…”

Section: Discussionmentioning

confidence: 99%

Zollinger–Ellison syndrome in a 12-year-old child

Nath

Saxena

Kulkarni

et al. 2017

J Indian Assoc Pediatr Surg

View full text Add to dashboard Cite

show abstract

“…Duodenal wall gastrinomas are frequently small, occult, multiple, and very hard to locate [ 14 , 15 ]. Sporadic tumors occurring in the pancreas tend to be solitary, larger, and have greater malignant potential compared to duodenal gastrinomas [ 16 ].…”

Section: Discussionmentioning

confidence: 99%

Zollinger-Ellison Syndrome Associated with von Recklinghausen Disease: Case Report and Literature Review

et al. 2016

View full text Add to dashboard Cite

Patient: Female, 28Final Diagnosis: GastrinomaSymptoms: Vomiting • diarrhea • epigastric soreness • heartburn • nausea • significant weight lossMedication: —Clinical Procedure: Esophagogastroduodenoscopy • blood tests • abdomen CT scan • surgerySpecialty: Gastroenterology and HepatologyObjective:Rare co-existance of disease or pathologyBackground:Pancreatic endocrine tumors (PETs) are rare and can occur as part of neurofibromatosis type 1 (NF1). Gastrinomas are functional PETs that are rarely associated with NF1. Only two cases of their occurrence have been reported in the literature.Case Report:A 28-year-old woman was admitted for further evaluation of epigastric soreness, heartburn, nausea, vomiting, diarrhea, and a significant weight loss. Physical examination was remarkable for cutaneous findings (axillary freckling and multiple café-au-lait spots) as well as neurofibromas (dermal, plexiform). A diagnosis of NF1 was confirmed.Esophagogastroduodenoscopy (EGD) revealed multiple ulcers in the duodenum and the upper jejunum. A fasting gastrin level exceeded ten times the normal limit. An abdominal multi-slice 128 computed tomography (CT) scan revealed an oval mass of 26 mm in diameter adjacent to the second segment of the duodenum. The patient was examined carefully to rule out multiple endocrine neoplasia type 1 (MEN1). Surgical resection was performed and a gastrinoma, causing Zollinger-Ellison syndrome (ZES), was diagnosed by histological examinations of the extirpated mass. The serum gastrin level decreased to normal limits shortly after surgery. Continuous follow-up revealed that the symptoms and the EGD findings completely resolved without recurrences.Conclusions:Although NF1 has common skeletal, visual, neurological, and cardiovascular complications, it also has a rare association with duodenal or pancreatic gastrinomas. Vigilance for this possible association is important to promote timely and careful management to help eliminate serious and potentially life-threatening complications.

show abstract

Pancreatic neuroendocrine tumours

Cited by 9 publications

References 8 publications

Postoperative Complications, In‐Hospital Mortality and 5‐Year Survival After Surgical Resection for Patients with a Pancreatic Neuroendocrine Tumor: A Systematic Review

Postoperative Complications, In‐Hospital Mortality and 5‐Year Survival After Surgical Resection for Patients with a Pancreatic Neuroendocrine Tumor: A Systematic Review

Zollinger–Ellison syndrome in a 12-year-old child

Zollinger-Ellison Syndrome Associated with von Recklinghausen Disease: Case Report and Literature Review

Contact Info

Product

Resources

About